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Chemical Compound Review:

DODAB dimethyl-dioctadecyl-azanium

Synonyms: Ddbas compound, AC1L1PRI, CTK8G9601, AR-1K2564, LS-173187, ...

Vangala, A. et al., Hanyecz, A. et al., Larsen, S.T. et al., Prager, M.D. et al., Kurth, D.G. et al., et al.

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Disease relevance of Dimethyldioctadecylammonium

We examined the role of cytokines in the development of gamma interferon (IFN-gamma)-secreting protective T cells following immunization with a culture filtrate subunit vaccine against Mycobacterium tuberculosis containing the adjuvant dimethyldioctadecylammonium bromide (DDA) [1].
Intracutaneous injections of killed listeria and DDA resulted in an antigen-dose dependent DH but not in ACR [2].
Dissociation between enhanced resistance and delayed hypersensitivity induced with subcellular preparations from Listeria monocytogenes and the adjuvant dimethyl-dioctadecyl-ammonium bromide [3].
Optimal conditions for the induction of ACR were simultaneous intraperitoneal injection of 15 mg DDA/kg body weight and 10(7) or 10(8) listeria [2].
In particular, we show that the nasal delivery of recombinant fragment (BBG2Na) of the G protein of respiratory syncytial virus (RSV) mixed with DDA induces both local and systemic anti-RSV immune responses and protects against viral challenge [4].

High impact information on Dimethyldioctadecylammonium

In therapy experiments BALB/c mice bearing P1798 were treated with methotrexate followed by immunotherapy with IAD-P1798 alone or complexed to DDA [5].
DDA exerts a strong stimulatory effect via the activation of nonspecific (innate) immunity and forces the immune regulation toward Th1 dominance [6].
OBJECTIVE: To apply and analyze the mechanisms of action of dimethyldioctadecylammonium bromide (DDA), a powerful adjuvant that does not have the side effects of the conventionally used Freund's adjuvants, in proteoglycan-induced arthritis (PGIA) and collagen-induced arthritis (CIA) [6].
Results from vibrational spectroscopy. analytical ultracentrifugation, small-angle X-ray scattering, transmission electron microscopy, elemental analysis, and Langmuir compression isotherms are consistent with a single polyoxometalate core encapsulated within a shell of 20 DODA molecules [7].
We investigated the role of interleukin-6 (IL-6) in the development of the immune response to a subunit vaccine against tuberculosis consisting of the culture filtrate proteins of Mycobacterium tuberculosis emulsified in the adjuvant dimethyldioctadecylammonium bromide (DDA) [8].

Chemical compound and disease context of Dimethyldioctadecylammonium

The adjuvants used were: muramyl dipeptide, Freund's incomplete adjuvant, dimethyl-dioctadecyl ammonium bromide (DDA), Bordetella pertussis and Propionibacterium acnes [9].

Biological context of Dimethyldioctadecylammonium

The kinetics of the observed alteration of the immune response by DDA and DXS were very similar [10].
The MP- and DDA-based systems induced antibody responses at comparable levels whereas the DDA-based systems induced more powerful cell-mediated immune responses [11].

Anatomical context of Dimethyldioctadecylammonium

Furthermore, RNA with DDA activated macrophages as shown by, a.o., enhanced phagocytic activity and killing capacity for L. monocytogenes [12].
Synergistic effects of two synthetic adjuvants, dimethyldioctadecylammonium bromide (DDA) and dextran sulfate (DXS) on the humoral response to sheep red blood cells (SRBC) were investigated [13].

Associations of Dimethyldioctadecylammonium with other chemical compounds

In this study, hazard identifications of the adjuvant effect of cetylpyridinium chloride (CPC), dimethyldioctadecylammonium bromide (DDA), hexadecyltrimethylammonium bromide (HTA), and tetraethylammonium chloride (TEA) were performed in a screening bioassay [14].
Differential scanning calorimetry revealed a reduction in the phase transition temperature (T(c)) of DDA-based vesicles by approximately 12 degrees C when MP and cholesterol (1:1 molar ratio) were incorporated into the DDA system [11].

Gene context of Dimethyldioctadecylammonium

CPC and DDA increased IgE and IgG1 antibody production, respectively, compared to the OVA control group, whereas HTA and TEA showed no adjuvant effect [14].
Adjuvants including Havlogen and dimethyldioctadecylammonium bromide (DDA), and carrier molecules including keyhole limpet hemocyanin (KLH), porcine thyroglobulin (TGB) and equine gamma globulin (EGG) were all found to be effective [15].

Analytical, diagnostic and therapeutic context of Dimethyldioctadecylammonium

With two and three cycles of therapy, methotrexate alone yielded 5 and 13% survivors, while adding immunotherapy with the DDA complex gave survival rates of 63 and 71% [5].
Intraperitoneal injection of DDA or DXS evoked a sequence of distinct immune responsive states in mice, measured by the capacity to develop an anti-SRBC response [10].
Transmission electron microscopy (TEM) revealed the addition of MP to DDA vesicles resulted in the formation of multi-lamellar vesicles [11].

References

Interleukin-6 and interleukin-12 participate in induction of a type 1 protective T-cell response during vaccination with a tuberculosis subunit vaccine. Leal, I.S., Smedegârd, B., Andersen, P., Appelberg, R. Infect. Immun. (1999) [Pubmed]
Delayed-type hypersensitivity and acquired cellular resistance in mice immunized with killed Listeria monocytogenes and adjuvants. Van Der Meer, C., Hofhuis, F.M., Willers, J.M. Immunology (1979) [Pubmed]
Dissociation between enhanced resistance and delayed hypersensitivity induced with subcellular preparations from Listeria monocytogenes and the adjuvant dimethyl-dioctadecyl-ammonium bromide. Antonissen, A.C., Lemmens, P.J., van den Bosch, J.F., van Boven, C.P. Antonie Van Leeuwenhoek (1986) [Pubmed]
Lipophilic quaternary ammonium salt acts as a mucosal adjuvant when co-administered by the nasal route with vaccine antigens. Klinguer, C., Beck, A., De-Lys, P., Bussat, M.C., Blaecke, A., Derouet, F., Bonnefoy, J.Y., Nguyen, T.N., Corvaïa, N., Velin, D. Vaccine (2001) [Pubmed]
Enhanced response to chemoimmunotherapy and immunoprophylaxis with the use of tumor-associated antigens with a lipophilic agent. Prager, M.D., Gordon, W.C. Cancer Res. (1978) [Pubmed]
Achievement of a synergistic adjuvant effect on arthritis induction by activation of innate immunity and forcing the immune response toward the Th1 phenotype. Hanyecz, A., Berlo, S.E., Szántó, S., Broeren, C.P., Mikecz, K., Glant, T.T. Arthritis Rheum. (2004) [Pubmed]
Surfactant-encapsulated clusters (SECs): (DODA)20(NH4)[H3Mo57V6(NO)6O183(H2O)18], a case study. Kurth, D.G., Lehmann, P., Volkmer, D., Cölfen, H., Koop, M.J., Müller, A., Du Chesne, A. Chemistry (Weinheim an der Bergstrasse, Germany) (2000) [Pubmed]
Interleukin-6 regulates the phenotype of the immune response to a tuberculosis subunit vaccine. Leal, I.S., Flórido, M., Andersen, P., Appelberg, R. Immunology (2001) [Pubmed]
The effects of adjuvants on immune responses in cattle injected with a Brucella abortus soluble antigen. Dzata, G.K., Confer, A.W., Wyckoff, J.H. Vet. Microbiol. (1991) [Pubmed]
Immunomodulating properties of two synthetic adjuvants: dependence upon type of antigen, dose, and time of administration. Hilgers, L.A., Snippe, H., Jansze, M., Willers, J.M. Cell. Immunol. (1984) [Pubmed]
A comparative study of cationic liposome and niosome-based adjuvant systems for protein subunit vaccines: characterisation, environmental scanning electron microscopy and immunisation studies in mice. Vangala, A., Kirby, D., Rosenkrands, I., Agger, E.M., Andersen, P., Perrie, Y. J. Pharm. Pharmacol. (2006) [Pubmed]
Ribonuclease-sensitive ribosomal vaccines. Gonggrijp, R., Antonissen, A.C., van den Bosch, J.F., van Boven, C.P. Antonie Van Leeuwenhoek (1984) [Pubmed]
Combinations of two synthetic adjuvants: synergistic effects of a surfactant and a polyanion on the humoral immune response. Hilgers, L.A., Snippe, H., Jansze, M., Willers, J.M. Cell. Immunol. (1985) [Pubmed]
Adjuvant effect of quaternary ammonium compounds in a murine model. Larsen, S.T., Hansen, R., Hammer, M., Tegner, U., Poulsen, O.M., Nielsen, G.D. Toxicol. Lett. (2004) [Pubmed]
A synthetic luteinizing hormone releasing hormone vaccine II. Temporal aspects of titer development and formulation trials in BALB/c mice. Silversides, D.W., Allen, A.F., Misra, V., Murphy, B.D., Mapletoft, R.J. J. Reprod. Immunol. (1988) [Pubmed]

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