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Gene Review

Cd5l  -  CD5 antigen-like

Mus musculus

Synonyms: 1/6, AAC-11, AI047839, AIM/Spalpha, Aim, ...
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Disease relevance of Cd5l

  • AIM (Spalpha/Api6) has previously been shown to promote macrophage survival; however, its function in atherogenesis is unknown [1].
  • The mutated gene fragment was exchanged for the wild-type copy in the previously cloned ctxAB operon from El Tor biotype, Ogawa serotype Vibrio cholerae strain 3083, which produces CT-2 [2].
  • BACKGROUND AND PURPOSE: Aim of this study was to assess the impact of the administration protocol of palifermin on amelioration of oral mucositis after fractionated irradiation [3].
  • PURPOSE: Aim of the study was the evaluation of the potential of novel tetanus toxoid (TT) loaded nanoparticles (NP) for electing an immune response in mice against TT [4].
  • Background and Aim: The neurotransmitter histamine is involved in the regulation of appetite and in the development of age-related obesity in mice [5].

High impact information on Cd5l


Biological context of Cd5l

  • A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis development [1].
  • Among changed genes, matrix metalloproteinase (MMP)-12, apoptosis inhibitor 6 (Api-6), erythroblast transformation-specific domain (Ets) transcription factor family member Spi-C, and oncogene MafB were increased 100-, 70-, 40-, and 10-fold, respectively, in lal-/- lungs versus the wild-type lungs [7].

Anatomical context of Cd5l

  • Binding of Sp alpha to conserved components of bacterial surfaces and modulation of the monocyte response indicate that this molecule is an active constituent of the innate immune response of the host [8].
  • Transcriptional activities of the MMP-12 and Api-6 promoters were stimulated by Spi-C or MafB in respiratory epithelial cells [7].
  • Background and Aim: Severe injury to the liver, such as that induced by toxic doses of acetaminophen, triggers a cascade of events leading to hepatocyte death [9].
  • Depletion of T cells from human bone marrow with monoclonal antibody CT-2 and complement [10].

Associations of Cd5l with chemical compounds

  • Bacterial binding studies using the SRCR domain 1 of Sp alpha showed that this domain retains both the LPS and LTA binding activities, indicating that both bacterial interacting sites are retained in a single SRCR domain [8].
  • The most conserved part of LPS (2-keto-3-deoxyoctulosonic acid and lipid A) was shown to be involved in the recognition by Sp alpha [8].
  • Consistent with previous studies in rats, we observed higher levels of cellular activity at CT2 than at CT14, and higher levels of activity in the "shell" than in the "core" of the SCN [11].
  • By contrast, melatonin administration for 3 consecutive days at the same clock time induced advances in circadian activity rhythms by more than 1 h when the first dose was administered at CT 10 and induced delays in circadian activity rhythms by up to 1 h when the first dose was administered between CT 24 and CT 2 [12].

Analytical, diagnostic and therapeutic context of Cd5l


  1. A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis development. Arai, S., Shelton, J.M., Chen, M., Bradley, M.N., Castrillo, A., Bookout, A.L., Mak, P.A., Edwards, P.A., Mangelsdorf, D.J., Tontonoz, P., Miyazaki, T. Cell metabolism. (2005) [Pubmed]
  2. Construction and characterization of recombinant Vibrio cholerae strains producing inactive cholera toxin analogs. Häse, C.C., Thai, L.S., Boesman-Finkelstein, M., Mar, V.L., Burnette, W.N., Kaslow, H.R., Stevens, L.A., Moss, J., Finkelstein, R.A. Infect. Immun. (1994) [Pubmed]
  3. Effects of keratinocyte growth factor (palifermin) administration protocols on oral mucositis (mouse) induced by fractionated irradiation. Dörr, W., Reichel, S., Spekl, K. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. (2005) [Pubmed]
  4. Tetanus toxoid loaded nanoparticles from sulfobutylated poly(vinyl alcohol)-graft-poly(lactide-co-glycolide): evaluation of antibody response after oral and nasal application in mice. Jung, T., Kamm, W., Breitenbach, A., Hungerer, K.D., Hundt, E., Kissel, T. Pharm. Res. (2001) [Pubmed]
  5. Increased susceptibility to diet-induced obesity in histamine-deficient mice. J??rgensen, E.A., Vogelsang, T.W., Knigge, U., Watanabe, T., Warberg, J., Kjaer, A. Neuroendocrinology (2006) [Pubmed]
  6. Identification of a novel inducible cell-surface ligand of CD5 on activated lymphocytes. Biancone, L., Bowen, M.A., Lim, A., Aruffo, A., Andres, G., Stamenkovic, I. J. Exp. Med. (1996) [Pubmed]
  7. Neutral lipids and peroxisome proliferator-activated receptor-{gamma} control pulmonary gene expression and inflammation-triggered pathogenesis in lysosomal acid lipase knockout mice. Lian, X., Yan, C., Qin, Y., Knox, L., Li, T., Du, H. Am. J. Pathol. (2005) [Pubmed]
  8. A role for human Sp alpha as a pattern recognition receptor. Sarrias, M.R., Roselló, S., Sánchez-Barbero, F., Sierra, J.M., Vila, J., Yélamos, J., Vives, J., Casals, C., Lozano, F. J. Biol. Chem. (2005) [Pubmed]
  9. Blockade of the receptor for advanced glycation end products attenuates acetaminophen-induced hepatotoxicity in mice. Ekong, U., Zeng, S., Dun, H., Feirt, N., Guo, J., Ippagunta, N., Guarrera, J.V., Lu, Y., Weinberg, A., Qu, W., Ramasamy, R., Schmidt, A.M., Emond, J.C. J. Gastroenterol. Hepatol. (2006) [Pubmed]
  10. Depletion of T cells from human bone marrow with monoclonal antibody CT-2 and complement. Trigg, M.E., Billing, R., Sondel, P.M., Dickerman, J.D., Erickson, C., Finlay, J.L., Bozdech, M., Hong, R., Padilla-Nash, H., Terasaki, P. Journal of biological response modifiers. (1984) [Pubmed]
  11. Spontaneous fos expression in the suprachiasmatic nucleus of young and old mice. Miller, J.P., McAuley, J.D., Pang, K.C. Neurobiol. Aging (2005) [Pubmed]
  12. Melatonin and light induce phase shifts of circadian activity rhythms in the C3H/HeN mouse. Benloucif, S., Dubocovich, M.L. J. Biol. Rhythms (1996) [Pubmed]
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