The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Clcnka  -  chloride channel Ka

Mus musculus

Synonyms: C75963, CLC-K1, Chloride channel Ka, Chloride channel protein ClC-Ka, ClC-K1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Clcnka


High impact information on Clcnka


Biological context of Clcnka


Anatomical context of Clcnka

  • Discontinuous axial expression of AQP1, UT-A2, and ClC-K1 along the straight portion of single thin limbs indicates that these nephrons possess a more heterogeneous structure than previously recognized [7].
  • We therefore examined whether kidney-specific chloride channels (ClC-K1 and ClC-K2) and ClC-5 are also expressed in OHCs of rat cochlea, assuming that these channels might be the targets of oto-nephrotoxic drugs, by single-cell reverse transcription-polymerase chain reaction (RT-PCR) technique [8].
  • mRNA expression of kidney-specific ClC-K1 chloride channel in single-cell reverse transcription-polymerase chain reaction analysis of outer hair cells of rat cochlea [8].
  • Luciferase activity was 7-to 24-fold greater in IM cells than those in nonexpressing cell lines, suggesting that the approximately 2.5-kb fragment contained cis-acting regulatory elements for cell-specific expression of the ClC-K1 gene [3].

Associations of Clcnka with chemical compounds

  • Furthermore, the accumulation of urea was also impaired in Clcnk1-/- mice, suggesting that the overall countercurrent system was impaired by a defect of its single component, chloride transport in the tAL [2].
  • These results suggest that the novel purine-rich element may play a key role in the activity of the ClC-K1 gene promoter [3].

Other interactions of Clcnka

  • Since immunohistochemical data indicates that ClC-K2, and perhaps ClC-K1, are present on the DCT basolateral membrane, we suggest that the channel detected in this study may belong to this subfamily of the ClC channel family [9].
  • We concluded that NDI in Clcnk1-/- mice resulted from an impairment in the generation of inner medullary hypertonicity by a dysfunction of the countercurrent systems [2].
  • The aldose reductase mRNA abundance in Clcnk1-/- mice was decreased, further evincing that inner medullary tonicity is decreased in Clcnk1-/- mice [2].
  • The addition of 300 microg/ml protamine, a selective blocker of paracellular conductance, to the bath increased the V(d) values by 5.6 +/- 0.7 and 12.6 +/- 1.5 mV (P < 0.001) in CLC-K1(+/+) and CLC-K1(-/-) mice, respectively [10].


  1. Overt nephrogenic diabetes insipidus in mice lacking the CLC-K1 chloride channel. Matsumura, Y., Uchida, S., Kondo, Y., Miyazaki, H., Ko, S.B., Hayama, A., Morimoto, T., Liu, W., Arisawa, M., Sasaki, S., Marumo, F. Nat. Genet. (1999) [Pubmed]
  2. Impaired solute accumulation in inner medulla of Clcnk1-/- mice kidney. Akizuki, N., Uchida, S., Sasaki, S., Marumo, F. Am. J. Physiol. Renal Physiol. (2001) [Pubmed]
  3. Isolation and characterization of kidney-specific ClC-K1 chloride channel gene promoter. Uchida, S., Rai, T., Yatsushige, H., Matsumura, Y., Kawasaki, M., Sasaki, S., Marumo, F. Am. J. Physiol. (1998) [Pubmed]
  4. Neuropathy target esterase catalyzes osmoprotective renal synthesis of glycerophosphocholine in response to high NaCl. Gallazzini, M., Ferraris, J.D., Kunin, M., Morris, R.G., Burg, M.B. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  5. Transcriptional regulation of the CLC-K1 promoter by myc-associated zinc finger protein and kidney-enriched Krüppel-like factor, a novel zinc finger repressor. Uchida, S., Tanaka, Y., Ito, H., Saitoh-Ohara, F., Inazawa, J., Yokoyama, K.K., Sasaki, S., Marumo, F. Mol. Cell. Biol. (2000) [Pubmed]
  6. Severely impaired urine-concentrating ability in mice lacking the CLC-K1 chloride channel. Uchida, S., Marumo, F. Exp. Nephrol. (2000) [Pubmed]
  7. Mixed descending- and ascending-type thin limbs of Henle's loop in mammalian renal inner medulla. Pannabecker, T.L., Dahlmann, A., Brokl, O.H., Dantzler, W.H. Am. J. Physiol. Renal Physiol. (2000) [Pubmed]
  8. mRNA expression of kidney-specific ClC-K1 chloride channel in single-cell reverse transcription-polymerase chain reaction analysis of outer hair cells of rat cochlea. Kawasaki, E., Hattori, N., Miyamoto, E., Yamashita, T., Inagaki, C. Neurosci. Lett. (2000) [Pubmed]
  9. A chloride channel at the basolateral membrane of the distal-convoluted tubule: a candidate ClC-K channel. Lourdel, S., Paulais, M., Marvao, P., Nissant, A., Teulon, J. J. Gen. Physiol. (2003) [Pubmed]
  10. Analysis of NaCl transport in thin ascending limb of Henle's loop in CLC-K1 null mice. Liu, W., Morimoto, T., Kondo, Y., Iinuma, K., Uchida, S., Sasaki, S., Marumo, F., Imai, M. Am. J. Physiol. Renal Physiol. (2002) [Pubmed]
WikiGenes - Universities