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Gene Review

Avpr2  -  arginine vasopressin receptor 2

Mus musculus

Synonyms: ADHR, AVPR V2, Antidiuretic hormone receptor, DI1, DIR, ...
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Disease relevance of Avpr2


Psychiatry related information on Avpr2


High impact information on Avpr2


Chemical compound and disease context of Avpr2


Biological context of Avpr2


Anatomical context of Avpr2


Associations of Avpr2 with chemical compounds

  • To determine if CD cAMP, generated from increased AVP-V2Rs, was accelerating the PKD, cystic mice and their normal littermates were treated with OPC31260, a relatively specific AVP-V2R antagonist [21].
  • Congenital nephrogenic diabetes insipidus (NDI) is a disease characterized by failure of the kidney to concentrate urine in response to vasopressin [22].
  • However, the underlying mechanism by which lithium causes NDI is poorly understood [23].
  • Furthermore, neither AVP nor V2 receptor agonist and antagonist alter cellular cAMP [24].
  • Alternatively, PGE2 might have reduced the affinities between ADH-receptor units and a component(s) of the series of processes leading to adenyl cyclase activation [25].

Regulatory relationships of Avpr2


Other interactions of Avpr2


Analytical, diagnostic and therapeutic context of Avpr2

  • The V2R product from the UrMm chimera was cleaved by a restriction enzyme known to digest only rat product, suggesting the PCR product was produced predominantly by cells derived from the ureteric bud [31].
  • Each mouse (male C57BL/6) received 3.6 nmol (approximately 50 microg) of either the control (nonsilencing) or one of the V2R-targeting siRNAs via intravenous injection [18].
  • As a model system, we studied a mutant V2 vasopressin receptor (AVPR2) containing the inactivating E242X nonsense mutation which mimics human X-linked nephrogenic diabetes insipidus (XNDI) when introduced into mice via gene targeting techniques [32].
  • The effects of water deprivation and the injection of deamino [8-D-arginine] vasopressin (dDAVP) on the metabolic activity of the hypothalamo-neurohypophysial neurones of mice with inherited nephrogenic diabetes insipidus (DI +/+ Severe) have been investigated by quantitative autoradiography using the [14C]2-deoxyglucose (2-DG) technique [6].
  • Sequence analysis indicates substantial homology to mouse V1R and V2R VNO receptor families [33].


  1. Generation and phenotype of mice harboring a nonsense mutation in the V2 vasopressin receptor gene. Yun, J., Schöneberg, T., Liu, J., Schulz, A., Ecelbarger, C.A., Promeneur, D., Nielsen, S., Sheng, H., Grinberg, A., Deng, C., Wess, J. J. Clin. Invest. (2000) [Pubmed]
  2. Congenital progressive hydronephrosis (cph) is caused by an S256L mutation in aquaporin-2 that affects its phosphorylation and apical membrane accumulation. McDill, B.W., Li, S.Z., Kovach, P.A., Ding, L., Chen, F. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  3. The aquaporin family of water channel proteins in clinical medicine. Lee, M.D., King, L.S., Agre, P. Medicine (Baltimore) (1997) [Pubmed]
  4. Physiology and pathophysiology of renal aquaporins. Kwon, T.H., Hager, H., Nejsum, L.N., Andersen, M.L., Frøkiaer, J., Nielsen, S. Semin. Nephrol. (2001) [Pubmed]
  5. A mouse model to test the in vivo efficacy of chemical chaperones. Bai, C., Biwersi, J., Verkman, A.S., Matthay, M.A. Journal of pharmacological and toxicological methods. (1998) [Pubmed]
  6. Effects of water deprivation and deamino [8-D-arginine] vasopressin on [14C]2-deoxyglucose uptake by the hypothalamo-hypophysial system in mice with hereditary nephrogenic diabetes insipidus. Sutherland, R.C., Fink, G., Morris, J.F. Brain Res. (1985) [Pubmed]
  7. Functional expression of murine V2R pheromone receptors involves selective association with the M10 and M1 families of MHC class Ib molecules. Loconto, J., Papes, F., Chang, E., Stowers, L., Jones, E.P., Takada, T., Kumánovics, A., Fischer Lindahl, K., Dulac, C. Cell (2003) [Pubmed]
  8. A putative pheromone receptor gene expressed in human olfactory mucosa. Rodriguez, I., Greer, C.A., Mok, M.Y., Mombaerts, P. Nat. Genet. (2000) [Pubmed]
  9. Overt nephrogenic diabetes insipidus in mice lacking the CLC-K1 chloride channel. Matsumura, Y., Uchida, S., Kondo, Y., Miyazaki, H., Ko, S.B., Hayama, A., Morimoto, T., Liu, W., Arisawa, M., Sasaki, S., Marumo, F. Nat. Genet. (1999) [Pubmed]
  10. Effective treatment of an orthologous model of autosomal dominant polycystic kidney disease. Torres, V.E., Wang, X., Qian, Q., Somlo, S., Harris, P.C., Gattone, V.H. Nat. Med. (2004) [Pubmed]
  11. Multiple new and isolated families within the mouse superfamily of V1r vomeronasal receptors. Rodriguez, I., Del Punta, K., Rothman, A., Ishii, T., Mombaerts, P. Nat. Neurosci. (2002) [Pubmed]
  12. Nephrogenic diabetes insipidus in mice lacking all nitric oxide synthase isoforms. Morishita, T., Tsutsui, M., Shimokawa, H., Sabanai, K., Tasaki, H., Suda, O., Nakata, S., Tanimoto, A., Wang, K.Y., Ueta, Y., Sasaguri, Y., Nakashima, Y., Yanagihara, N. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  13. Vasopressin and ethanol preference. II. Altered preference in two strains of diabetes insipidus rats and nephrogenic diabetes insipidus mice. Crabbe, J.C., Rigter, H. Peptides (1985) [Pubmed]
  14. Mouse model of inducible nephrogenic diabetes insipidus produced by floxed aquaporin-2 gene deletion. Yang, B., Zhao, D., Qian, L., Verkman, A.S. Am. J. Physiol. Renal Physiol. (2006) [Pubmed]
  15. Comparative mapping on the mouse and human X chromosomes of a human cDNA clone encoding the vasopressin renal-type receptor (AVP2R). Faust, C.J., Gonzales, J.C., Seibold, A., Birnbaumer, M., Herman, G.E. Genomics (1993) [Pubmed]
  16. MHC class I peptides as chemosensory signals in the vomeronasal organ. Leinders-Zufall, T., Brennan, P., Widmayer, P., S, P.C., Maul-Pavicic, A., Jäger, M., Li, X.H., Breer, H., Zufall, F., Boehm, T. Science (2004) [Pubmed]
  17. V1a vasopressin receptors maintain normal blood pressure by regulating circulating blood volume and baroreflex sensitivity. Koshimizu, T.A., Nasa, Y., Tanoue, A., Oikawa, R., Kawahara, Y., Kiyono, Y., Adachi, T., Tanaka, T., Kuwaki, T., Mori, T., Takeo, S., Okamura, H., Tsujimoto, G. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  18. Small interfering RNA-mediated functional silencing of vasopressin V2 receptors in the mouse kidney. Hassan, A., Tian, Y., Zheng, W., Ji, H., Sandberg, K., Verbalis, J.G. Physiol. Genomics (2005) [Pubmed]
  19. The behavioral effect of vasopressin in the ventral hippocampus is antagonized by an oxytocin receptor antagonist. Paban, V., Alescio-Lautier, B., Devigne, C., Soumireu-Mourat, B. Eur. J. Pharmacol. (1998) [Pubmed]
  20. Role of aquaporin water channels in kidney and lung. Verkman, A.S. Am. J. Med. Sci. (1998) [Pubmed]
  21. Developmental expression of urine concentration-associated genes and their altered expression in murine infantile-type polycystic kidney disease. Gattone, V.H., Maser, R.L., Tian, C., Rosenberg, J.M., Branden, M.G. Dev. Genet. (1999) [Pubmed]
  22. Diabetes insipidus in mice with a mutation in aquaporin-2. Lloyd, D.J., Hall, F.W., Tarantino, L.M., Gekakis, N. PLoS Genet. (2005) [Pubmed]
  23. Development of lithium-induced nephrogenic diabetes insipidus is dissociated from adenylyl cyclase activity. Li, Y., Shaw, S., Kamsteeg, E.J., Vandewalle, A., Deen, P.M. J. Am. Soc. Nephrol. (2006) [Pubmed]
  24. PGE2 enhances cytokine-elicited nitric oxide production in mouse cortical collecting duct cells. Huang, C.N., Liu, K.L., Cheng, C.H., Lin, Y.S., Lin, M.J., Lin, T.H. Nitric Oxide (2005) [Pubmed]
  25. Interactions among prostaglandin E2, antidiuretic hormone, and cyclic adenosine monophosphate in modulating Cl- absorption in single mouse medullary thick ascending limbs of Henle. Culpepper, R.M., Andreoli, T.E. J. Clin. Invest. (1983) [Pubmed]
  26. Erythrocyte water permeability and renal function in double knockout mice lacking aquaporin-1 and aquaporin-3. Yang, B., Ma, T., Verkman, A.S. J. Biol. Chem. (2001) [Pubmed]
  27. Monensin-resistant LLC-PK1 cell mutants are affected in recycling of the adenylate cyclase-stimulating vasopressin V2-receptor. Jans, D.A., Jans, P., Luzius, H., Fahrenholz, F. Mol. Cell. Endocrinol. (1991) [Pubmed]
  28. Mild nephrogenic diabetes insipidus caused by Foxa1 deficiency. Behr, R., Brestelli, J., Fulmer, J.T., Miyawaki, N., Kleyman, T.R., Kaestner, K.H. J. Biol. Chem. (2004) [Pubmed]
  29. Aldose reductase-deficient mice develop nephrogenic diabetes insipidus. Ho, H.T., Chung, S.K., Law, J.W., Ko, B.C., Tam, S.C., Brooks, H.L., Knepper, M.A., Chung, S.S. Mol. Cell. Biol. (2000) [Pubmed]
  30. Impaired solute accumulation in inner medulla of Clcnk1-/- mice kidney. Akizuki, N., Uchida, S., Sasaki, S., Marumo, F. Am. J. Physiol. Renal Physiol. (2001) [Pubmed]
  31. Metanephric rat-mouse chimeras to study cell lineage of the nephron. Arend, L.J., Smart, A., Briggs, J.P. Dev. Genet. (1999) [Pubmed]
  32. Aminoglycoside-mediated rescue of a disease-causing nonsense mutation in the V2 vasopressin receptor gene in vitro and in vivo. Sangkuhl, K., Schulz, A., Römpler, H., Yun, J., Wess, J., Schöneberg, T. Hum. Mol. Genet. (2004) [Pubmed]
  33. Identification of non-functional human VNO receptor genes provides evidence for vestigiality of the human VNO. Kouros-Mehr, H., Pintchovski, S., Melnyk, J., Chen, Y.J., Friedman, C., Trask, B., Shizuya, H. Chem. Senses (2001) [Pubmed]
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