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Gene Review

Clcn5  -  chloride channel, voltage-sensitive 5

Rattus norvegicus

Synonyms: Chloride channel protein 5, Chloride transporter ClC-5, ClC-5, H(+)/Cl(-) exchange transporter 5
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Disease relevance of Clcn5


High impact information on Clcn5

  • A detailed analysis revealed that ClC-3 was expressed by type B intercalated cells, whereas ClC-5 was expressed by type A intercalated cells [1].
  • We now report on the precise intrarenal localization of the mRNAs coding for the chloride channels ClC-2, ClC-3 and ClC-5 [1].
  • The molecular structure and functional properties of ClC-5 will provide an important insight into ORCCs and the pathogenesis of Dent's disease [4].
  • To characterize the functional properties of ClC-5 by whole cell patch-clamp technique, we established the stably transfected CHO-K1 cell line using intranuclear microinjection technique [4].
  • Animals with higher urinary calcium concentrations have lower levels of ClC-5 mRNA and protein expression, suggesting that the ClC-5 chloride channel plays a role in calcium reabsorption [5].

Biological context of Clcn5

  • To determine whether ClC-5 is also involved in calcium homeostasis, we investigated whether ClC-5 mRNA and protein expression are modulated in rats deficient in 1alpha,25(OH)(2) vitamin D(3) with and without thyroparathyroidectomy [5].
  • Tissue distribution and subcellular localization of the ClC-5 chloride channel in rat intestinal cells [2].
  • These findings suggest that ClC-5 might be involved in the endocytosis and/or the H+ secretion in the proximal tubule cells and the cortical collecting duct type A intercalated cells in mouse kidney [6].

Anatomical context of Clcn5


Associations of Clcn5 with chemical compounds


Physical interactions of Clcn5

  • These findings are consistent with a potential role for ClC-3 in transepithelial chloride transport by principal cells and for ClC-5 in the acidification of H(+)-ATPase-containing vesicles in narrow and clear cells [8].

Other interactions of Clcn5

  • Single-cell RT-PCR revealed the presence of transcripts of ClC-K1 in OHCs which was verified by DNA sequencing, while ClC-K2 and ClC-5 were not detected [10].

Analytical, diagnostic and therapeutic context of Clcn5


  1. The swelling-activated chloride channel ClC-2, the chloride channel ClC-3, and ClC-5, a chloride channel mutated in kidney stone disease, are expressed in distinct subpopulations of renal epithelial cells. Obermüller, N., Gretz, N., Kriz, W., Reilly, R.F., Witzgall, R. J. Clin. Invest. (1998) [Pubmed]
  2. Tissue distribution and subcellular localization of the ClC-5 chloride channel in rat intestinal cells. Vandewalle, A., Cluzeaud, F., Peng, K.C., Bens, M., Lüchow, A., Günther, W., Jentsch, T.J. Am. J. Physiol., Cell Physiol. (2001) [Pubmed]
  3. Reduced renal ClC-5 Cl- channel expression in spontaneously hypertensive rats with microalbuminuria. Tanaka, K., Nakaki, T. Eur. J. Pharmacol. (2004) [Pubmed]
  4. Identification of a new outwardly rectifying Cl- channel that belongs to a subfamily of the ClC Cl- channels. Sakamoto, H., Kawasaki, M., Uchida, S., Sasaki, S., Marumo, F. J. Biol. Chem. (1996) [Pubmed]
  5. PTH regulates expression of ClC-5 chloride channel in the kidney. Silva, I.V., Blaisdell, C.J., Guggino, S.E., Guggino, W.B. Am. J. Physiol. Renal Physiol. (2000) [Pubmed]
  6. Cellular and subcellular immunolocalization of ClC-5 channel in mouse kidney: colocalization with H+-ATPase. Sakamoto, H., Sado, Y., Naito, I., Kwon, T.H., Inoue, S., Endo, K., Kawasaki, M., Uchida, S., Nielsen, S., Sasaki, S., Marumo, F. Am. J. Physiol. (1999) [Pubmed]
  7. Biophysical properties of ClC-3 differentiate it from swelling-activated chloride channels in Chinese hamster ovary-K1 cells. Li, X., Shimada, K., Showalter, L.A., Weinman, S.A. J. Biol. Chem. (2000) [Pubmed]
  8. Detection of ClC-3 and ClC-5 in epididymal epithelium: immunofluorescence and RT-PCR after LCM. Isnard-Bagnis, C., Da Silva, N., Beaulieu, V., Yu, A.S., Brown, D., Breton, S. Am. J. Physiol., Cell Physiol. (2003) [Pubmed]
  9. ClC-5: ontogeny of an alternative chloride channel in respiratory epithelia. Edmonds, R.D., Silva, I.V., Guggino, W.B., Butler, R.B., Zeitlin, P.L., Blaisdell, C.J. Am. J. Physiol. Lung Cell Mol. Physiol. (2002) [Pubmed]
  10. mRNA expression of kidney-specific ClC-K1 chloride channel in single-cell reverse transcription-polymerase chain reaction analysis of outer hair cells of rat cochlea. Kawasaki, E., Hattori, N., Miyamoto, E., Yamashita, T., Inagaki, C. Neurosci. Lett. (2000) [Pubmed]
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