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Gene Review

Cyp2a4  -  cytochrome P450, family 2, subfamily a,...

Mus musculus

Synonyms: AI893559, CYPIIA4, Cyp15a1, Cyp2a-4, Cytochrome P450 2A4, ...
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Disease relevance of Cyp2a4


High impact information on Cyp2a4


Biological context of Cyp2a4


Associations of Cyp2a4 with chemical compounds


Regulatory relationships of Cyp2a4

  • These data indicate that the Cyp2a-4/5 complex is regulated in a different way in DBA/2 and C57BL/6 mice and that some association exists between the development of liver damage and COH induction [10].
  • It appears, therefore, that HNF-4 activates the hepatic transcription of Cyp2a-4 gene through its direct binding to the regulatory element regardless of the methylation at position -50 [8].

Other interactions of Cyp2a4

  • Also in the kidneys the increase in COH activity and in Cyp2a-4/5 mRNA was marked only in the DBA/2 mice [10].
  • In contrast, male mice treated with NP showed increased expression of Cyp2a4, Cyp2b9, and Cyp2b10 [13].
  • Nuclear localization of Stat5b correlates with the repression of Cyp2a4 and expression of Cyp2d9, respectively [14].
  • Transcriptional regulation by HNF-4 of the steroid 15alpha-hydroxylase P450 (Cyp2a-4) gene in mouse liver [8].
  • Developmental action of estrogen receptor-alpha feminizes the growth hormone-Stat5b pathway and expression of Cyp2a4 and Cyp2d9 genes in mouse liver [14].

Analytical, diagnostic and therapeutic context of Cyp2a4

  • Northern blot analysis showed a 21-fold increase in the hepatic Cyp2a-4/5 mRNA in the DBA/2 mice at day 2, whereas no increase occurred in the C57BL/6 mice [10].
  • PCR amplification of a 1 kb region in Cyp2a-4/5-mRNA-derived cDNA, followed by cutting at the diagnostic PstI site, showed that most of the steady-state mRNA consisted of Cyp2a-5, which is also the form most affected by pyrazole [11].
  • Two highly homologous cDNA clones encoding P-450 15 alpha designated type I and type II were identified, and levels of type I and type II mRNA in liver and kidney were determined by differential restriction mapping of double-stranded cDNA prepared from mRNA from these tissues.(ABSTRACT TRUNCATED AT 250 WORDS)[15]
  • Castration of male mice lowers kidney levels of P-450 15 alpha but in the liver, P-450 15 alpha levels rise after castration [15].


  1. Overexpression of a cytochrome P-450 of the 2a family (Cyp2a-5) in chemically induced hepatomas from female mice. Jounaïdi, Y., Bonfils, C., Périn, F., Negishi, M., Lange, R. Eur. J. Biochem. (1994) [Pubmed]
  2. Circadian expression of the steroid 15 alpha-hydroxylase (Cyp2a4) and coumarin 7-hydroxylase (Cyp2a5) genes in mouse liver is regulated by the PAR leucine zipper transcription factor DBP. Lavery, D.J., Lopez-Molina, L., Margueron, R., Fleury-Olela, F., Conquet, F., Schibler, U., Bonfils, C. Mol. Cell. Biol. (1999) [Pubmed]
  3. Reciprocal regulation of sex-dependent expression of testosterone 15 alpha-hydroxylase (P-450(15 alpha)) in liver and kidney of male mice by androgen. Evidence for a single gene. Squires, E.J., Negishi, M. J. Biol. Chem. (1988) [Pubmed]
  4. Sexual dimorphism of testosterone 15 alpha-hydroxylase mRNA levels in mouse liver. cDNA cloning and regulation. Burkhart, B.A., Harada, N., Negishi, M. J. Biol. Chem. (1985) [Pubmed]
  5. Mouse liver testosterone 15 alpha-hydroxylase (cytochrome P-450(15) alpha). Purification, regioselectivity, stereospecificity, and sex-dependent expression. Harada, N., Negishi, M. J. Biol. Chem. (1984) [Pubmed]
  6. Role of the peroxisome proliferator-activated receptor alpha in responses to diisononyl phthalate. Valles, E.G., Laughter, A.R., Dunn, C.S., Cannelle, S., Swanson, C.L., Cattley, R.C., Corton, J.C. Toxicology (2003) [Pubmed]
  7. The inhibition of CYP enzymes in mouse and human liver by pilocarpine. Kimonen, T., Juvonen, R.O., Alhava, E., Pasanen, M. Br. J. Pharmacol. (1995) [Pubmed]
  8. Transcriptional regulation by HNF-4 of the steroid 15alpha-hydroxylase P450 (Cyp2a-4) gene in mouse liver. Yokomori, N., Nishio, K., Aida, K., Negishi, M. J. Steroid Biochem. Mol. Biol. (1997) [Pubmed]
  9. Genetic regulation of testosterone 15 alpha-hydroxylase (cytochrome P-450(15)alpha) in renal microsomes of female mice. Squires, E.J., Negishi, M. Biochemistry (1986) [Pubmed]
  10. Cerium-induced strain-dependent increase in Cyp2a-4/5 (cytochrome P4502a-4/5) expression in the liver and kidneys of inbred mice. Salonpää, P., Iscan, M., Pasanen, M., Arvela, P., Pelkonen, O., Raunio, H. Biochem. Pharmacol. (1992) [Pubmed]
  11. Effect of pyrazole, cobalt and phenobarbital on mouse liver cytochrome P-450 2a-4/5 (Cyp2a-4/5) expression. Hahnemann, B., Salonpää, P., Pasanen, M., Mäenpää, J., Honkakoski, P., Juvonen, R., Lang, M.A., Pelkonen, O., Raunio, H. Biochem. J. (1992) [Pubmed]
  12. Lack of the steroid 15 alpha-hydroxylase gene (Cyp2a-4) in wild mouse strain Mus spretus: rapid evolution of the P450 gene superfamily. Aida, K., Moore, R., Negishi, M. Genomics (1994) [Pubmed]
  13. Gender-specific induction of cytochrome P450s in nonylphenol-treated FVB/NJ mice. Hernandez, J.P., Chapman, L.M., Kretschmer, X.C., Baldwin, W.S. Toxicol. Appl. Pharmacol. (2006) [Pubmed]
  14. Developmental action of estrogen receptor-alpha feminizes the growth hormone-Stat5b pathway and expression of Cyp2a4 and Cyp2d9 genes in mouse liver. Sueyoshi, T., Yokomori, N., Korach, K.S., Negishi, M. Mol. Pharmacol. (1999) [Pubmed]
  15. Tissue-specific regulation of cytochrome P-450 dependent testosterone 15 alpha-hydroxylase. Squires, E.J., Negishi, M. Can. J. Physiol. Pharmacol. (1990) [Pubmed]
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