The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Gna15  -  guanine nucleotide binding protein, alpha 15

Mus musculus

Synonyms: G alpha-15, G-protein subunit alpha-15, G[a]15, Galpha15, Gna-15, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Gna15


High impact information on Gna15


Biological context of Gna15

  • Normal hematopoiesis and inflammatory responses despite discrete signaling defects in Galpha15 knockout mice [2].
  • One is a Galphaq in the narrow sense, and the other, termed rat Galpha15, is a rat counterpart of mouse Galpha15, sharing an amino acid sequence similarity of 94% [3].
  • A comparison with the mutant Thr370Lys alpha2B AR-Galpha15 fusion protein displayed similar Ca2+ kinetics and a ligand-mediated receptor activation profile characterized by higher potencies and greater maximal Ca2+ responses for the ligands being investigated, including the putative antagonists dexefaroxan and idazoxan [4].

Anatomical context of Gna15


Associations of Gna15 with chemical compounds

  • Activation of the wild-type alpha2B AR-Galpha15 fusion protein in CHO-K1 cells by (-)-adrenaline induced a time- and concentration-dependent (pEC50 = 7.37+/-0.13) increase in the intracellular Ca2+ concentration, which could be antagonized by RX 811059 (pK(B) = 7.55+/-0.15) [4].

Regulatory relationships of Gna15

  • Despite discrete signaling defects, compensation by coexpressed Gq and/or Gi class alpha subunits may suppress abnormalities in Galpha15-deficient mice [2].

Other interactions of Gna15

  • A recently described large molecular weight G protein, G alpha h (Nakaoka et al., 1994: Science 264:1593-1596), was also present, G alpha 15, G alpha t1, G alpha olf, G alpha oA, G beta 3, G gamma 1, and G gamma 8 mRNA transcripts were not detected using this method [5].

Analytical, diagnostic and therapeutic context of Gna15


  1. Characterization of G-protein alpha subunits in the Gq class: expression in murine tissues and in stromal and hematopoietic cell lines. Wilkie, T.M., Scherle, P.A., Strathmann, M.P., Slepak, V.Z., Simon, M.I. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  2. Normal hematopoiesis and inflammatory responses despite discrete signaling defects in Galpha15 knockout mice. Davignon, I., Catalina, M.D., Smith, D., Montgomery, J., Swantek, J., Croy, J., Siegelman, M., Wilkie, T.M. Mol. Cell. Biol. (2000) [Pubmed]
  3. Identification of two alpha-subunit species of GTP-binding proteins, Galpha15 and Galphaq, expressed in rat taste buds. Kusakabe, Y., Yamaguchi, E., Tanemura, K., Kameyama, K., Chiba, N., Arai, S., Emori, Y., Abe, K. Biochim. Biophys. Acta (1998) [Pubmed]
  4. Ligand-receptor interactions as controlled by wild-type and mutant Thr(370)Lys alpha2B-adrenoceptor-Galpha15 fusion proteins. Pauwels, P.J., Tardif, S., Finana, F., Wurch, T., Colpaert, F.C. J. Neurochem. (2000) [Pubmed]
  5. G protein gene expression during mouse oocyte growth and maturation, and preimplantation embryo development. Williams, C.J., Schultz, R.M., Kopf, G.S. Mol. Reprod. Dev. (1996) [Pubmed]
  6. Promiscuous coupling of receptors to Gq class alpha subunits and effector proteins in pancreatic and submandibular gland cells. Xu, X., Croy, J.T., Zeng, W., Zhao, L., Davignon, I., Popov, S., Yu, K., Jiang, H., Offermanns, S., Muallem, S., Wilkie, T.M. J. Biol. Chem. (1998) [Pubmed]
WikiGenes - Universities