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Gene Review

GNA15  -  guanine nucleotide binding protein (G...

Homo sapiens

Synonyms: Epididymis tissue protein Li 17E, G alpha-15, G alpha-16, G-protein subunit alpha-15, G-protein subunit alpha-16, ...
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Disease relevance of GNA15


High impact information on GNA15


Biological context of GNA15


Anatomical context of GNA15


Associations of GNA15 with chemical compounds

  • In addition, stimulation of inositol phosphate formation via receptors naturally coupled to phospholipase C was enhanced by cotransfection of G alpha 15 and G alpha 16 [9].
  • Coupling of metabotropic glutamate receptors 2 and 4 to G alpha 15, G alpha 16, and chimeric G alpha q/i proteins: characterization of new antagonists [10].
  • HEK-293 cells cotransfected with this clone, and a cDNA encoding G alpha-16 specifically bound (Kd = 1.6+/-0.7 nM) and responded functionally to C3a with an intracellular calcium mobilization (ED50 = 0.18+/-0.02 nM) [11].
  • Interestingly, in a mutant with a single exchange of Ser449 to Ala, the signal transduction assessed by a Ca(2+) assay and [(35)S]GTP gamma S-binding on HEK cells transiently co-transfected with G-alpha 16 or G-alpha O, respectively, was severely impaired, indicating that this residue of C3aR is involved in G protein coupling [12].
  • In contrast to mastoparan, iC5b67 failed to directly activate G proteins to stimulate inositol phosphate formation in COS cells that had been transfected with G alpha 16 [13].

Physical interactions of GNA15


Regulatory relationships of GNA15


Other interactions of GNA15


Analytical, diagnostic and therapeutic context of GNA15


  1. G alpha 16, a G protein alpha subunit specifically expressed in hematopoietic cells. Amatruda, T.T., Steele, D.A., Slepak, V.Z., Simon, M.I. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  2. G protein subunit G alpha 16 expression is restricted to progenitor B cells during human B-cell differentiation. Mapara, M.Y., Bommert, K., Bargou, R.C., Leng, C., Beck, C., Ludwig, W.D., Gierschik, P., Dörken, B. Blood (1995) [Pubmed]
  3. Expression of G alpha 16, a G-protein alpha subunit specific for hematopoiesis in acute leukemia. Pfeilstöcker, M., Karlic, H., Salamon, J., Krömer, E., Mühlberger, H., Pavlova, B., Selim, U., Tüchler, H., Fritsch, G., Kneissl, S., Heinz, R., Pitterman, E., Paukovits, M.R. Leukemia (1996) [Pubmed]
  4. Activation of phospholipase C beta 2 by the alpha and beta gamma subunits of trimeric GTP-binding protein. Wu, D., Katz, A., Simon, M.I. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  5. Expression cloning of the human C3a anaphylatoxin receptor (C3aR) from differentiated U-937 cells. Crass, T., Raffetseder, U., Martin, U., Grove, M., Klos, A., Köhl, J., Bautsch, W. Eur. J. Immunol. (1996) [Pubmed]
  6. Tandem genomic arrangement of a G protein (Gna15) and G protein-coupled receptor (s1p(4)/lp(C1)/Edg6) gene. Contos, J.J., Ye, X., Sah, V.P., Chun, J. FEBS Lett. (2002) [Pubmed]
  7. Selective coupling of beta 2-adrenergic receptor to hematopoietic-specific G proteins. Wu, D., Kuang, Y., Wu, Y., Jiang, H. J. Biol. Chem. (1995) [Pubmed]
  8. Two Gq class G proteins are expressed in human keratinocytes. Rock, B.M., Xin, L., Wilcox, J.N. J. Invest. Dermatol. (1997) [Pubmed]
  9. G alpha 15 and G alpha 16 couple a wide variety of receptors to phospholipase C. Offermanns, S., Simon, M.I. J. Biol. Chem. (1995) [Pubmed]
  10. Coupling of metabotropic glutamate receptors 2 and 4 to G alpha 15, G alpha 16, and chimeric G alpha q/i proteins: characterization of new antagonists. Gomeza, J., Mary, S., Brabet, I., Parmentier, M.L., Restituito, S., Bockaert, J., Pin, J.P. Mol. Pharmacol. (1996) [Pubmed]
  11. Human anaphylatoxin C4a is a potent agonist of the guinea pig but not the human C3a receptor. Lienenklaus, S., Ames, R.S., Tornetta, M.A., Sarau, H.M., Foley, J.J., Crass, T., Sohns, B., Raffetseder, U., Grove, M., Hölzer, A., Klos, A., Köhl, J., Bautsch, W. J. Immunol. (1998) [Pubmed]
  12. Structure-function studies of the C3a-receptor: C-terminal serine and threonine residues which influence receptor internalization and signaling. Settmacher, B., Rheinheimer, C., Hamacher, H., Ames, R.S., Wise, A., Jenkinson, L., Bock, D., Schaefer, M., Köhl, J., Klos, A. Eur. J. Immunol. (2003) [Pubmed]
  13. Signaling by hemolytically inactive C5b67, an agonist of polymorphonuclear leukocytes. Wang, C., Gerard, N.P., Nicholson-Weller, A. J. Immunol. (1996) [Pubmed]
  14. G alpha 16 couples chemoattractant receptors to NF-kappa B activation. Yang, M., Sang, H., Rahman, A., Wu, D., Malik, A.B., Ye, R.D. J. Immunol. (2001) [Pubmed]
  15. Activation of phospholipase C by alpha 1-adrenergic receptors is mediated by the alpha subunits of Gq family. Wu, D., Katz, A., Lee, C.H., Simon, M.I. J. Biol. Chem. (1992) [Pubmed]
  16. Reconstitution of chemokine-induced actin polymerization in undifferentiated human leukemia cells (HL-60) by heterologous expression of interleukin-8 receptors. Norgauer, J., Metzner, B., Czech, W., Schraufstatter, I. Inflamm. Res. (1996) [Pubmed]
  17. Multiple regions of G alpha 16 contribute to the specificity of activation by the C5a receptor. Lee, C.H., Katz, A., Simon, M.I. Mol. Pharmacol. (1995) [Pubmed]
  18. Differential G-protein expression during B- and T-cell development. Grant, K.R., Harnett, W., Milligan, G., Harnett, M.M. Immunology (1997) [Pubmed]
  19. A bioluminescent assay for agonist activity at potentially any G-protein-coupled receptor. Stables, J., Green, A., Marshall, F., Fraser, N., Knight, E., Sautel, M., Milligan, G., Lee, M., Rees, S. Anal. Biochem. (1997) [Pubmed]
  20. Coupling of the C5a receptor to Gi in U-937 cells and in cells transfected with C5a receptor cDNA. Vanek, M., Hawkins, L.D., Gusovsky, F. Mol. Pharmacol. (1994) [Pubmed]
  21. Monitoring of hematopoietic recovery after autologous stem cell transplantation by analysis of G alpha 16 mRNA and CD34 surface glycoprotein. Pfeilstöcker, M., Karlic, H., Salamon, J., Mühlberger, H., Pavlova, B., Selim, U., Strobl, H., Pittermann, E., Heinz, R. Ann. Hematol. (1998) [Pubmed]
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