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JAKMIP1  -  janus kinase and microtubule interacting...

Homo sapiens

Synonyms: FLJ31564, GABA-B receptor-binding protein, GABABRBP, Gababrbp, JAMIP1, ...
 
 
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Disease relevance of JAKMIP1

  • Single white fibres and small bundles (two to three) of red fibres were isolated from the trunk muscle of Pacific Blue Marlin (50-121 kg body weight) [1].
  • The application of this method to detect amines in fried marlin fillet implicated in a food poisoning incident indicated that a high level (56.24 mg/100 g) of histamine was present in the sample [2].
 

High impact information on JAKMIP1

  • The urinary excretion of histamine and its metabolite, N-methylhistamine, was measured in three persons who had scombroid-fish poisoning (scombrotoxism) after the ingestion of marlin [3].
  • The restricted expression of Jamip1 and its ability to associate to and modify microtubule polymers suggest a specialized function of these proteins in dynamic processes, e.g. cell polarization, segregation of signaling complexes, and vesicle traffic, some of which may involve Jak tyrosine kinases [4].
  • Jamip1 (marlin-1) defines a family of proteins interacting with janus kinases and microtubules [4].
  • Jamip proteins lack known domains and are extremely rich in predicted coiled coils that mediate dimerization [4].
  • In our initial characterization of Jamip1 (73 kDa), we found that it comprises an N-terminal region that targets the protein to microtubule polymers and, when overexpressed in fibroblasts, profoundly perturbs the microtubule network, inducing the formation of tight and stable bundles [4].
 

Biological context of JAKMIP1

  • Isolation and characterization of novel polymorphic tetra-nucleotide microsatellite markers from the blue marlin, Makaira nigricans [5].
  • Effects of Ca2+ on oxidative phosphorylation in mitochondria from the thermogenic organ of marlin [6].
  • Mitochondria from the muscle-derived thermogenic (heater) organ and oxidative red muscle of the blue marlin (Makaira nigricans) were studied in order to evaluate aspects of the mechanism of thermogenesis in heater tissue [6].
  • Vmax (muscle lengths s-1) at normal body temperatures are 0.9 for icefish (-1 degree C), 1.0 for cod (8 degrees C) and 3.4 for marlin (20 degrees C) [7].
  • Spermatozoa were recovered from the spermatic duct of testes retrieved post-mortem from four adult black marlin caught in the Coral Sea spawning grounds of Australia. Undiluted spermatozoa were stored on ice for 4 to 10 hours during transport to shore, then evaluated for motility after activation in seawater (a volume ratio of 1 to 10) [8].
 

Anatomical context of JAKMIP1

 

Associations of JAKMIP1 with chemical compounds

  • The recovery of methylmercury was 91.2-95.3% for tuna, 89.3-94.7% for marlin, and 91.7-94.8% for shark, respectively [11].
  • Dietary intake estimations found that provided fresh and frozen tuna, marlin, swordfish or shark are consumed once a month or less, the dietary intakes of total mercury by women of child-bearing age, averaged over 1 month, would fall below the Joint FAO/WHO Expert Committee on Food Additives provisional tolerable weekly intake for total mercury [12].
  • As a first step towards the development of a method for the cryopreservation of black marlin spermatozoa, this study investigated the effect of dimethylsulfoxide (DMSO) concentration and pellet size on post-thaw spermatozoal motility [8].
  • This finding is important given that the Atlantic stocks of blue marlin are considered endangered [13].
  • Blood from capture-stressed striped marlin cannot be fully saturated with oxygen in the presence of lactic acid because of a substantial Root effect [14].
 

Other interactions of JAKMIP1

  • Characterization of ryanodine receptor and Ca2+-ATPase isoforms in the thermogenic heater organ of blue marlin (Makaira nigricans) [15].
  • Parvalbumin is not responsible for cross-reactivity between tuna and marlin: A case report [16].
  • The HRC contribution to total cellular buffering varied from a high of 62% for marlin white to a low of 7% for trout red [17].
  • We were able to differentiate between species of billfish (Istiophoridae family) and to detect considerable intraspecific variation in the blue marlin (Makaira nigricans) by directly sequencing a polymerase chain reaction (PCR)-amplified, 612-bp fragment of the mitochondrial cytochrome b gene [13].
 

Analytical, diagnostic and therapeutic context of JAKMIP1

  • A number of studies have clearly shown that the ability of both man and horses to perform a standardised exercise test in hot humid conditions is reduced compared to that in hot dry or cool conditions (see reviews by Maughan and Lindinger, 1995; Lindinger and Marlin, 1995) [18].
  • To gain insight into heater cell origins, we characterized blue marlin superior rectus muscle and its heater tissue derivative with histochemical and immunological techniques [19].

References

  1. Power output and force-velocity relationship of red and white muscle fibres from the Pacific blue marlin (Makaira nigricans). Johnston, I.A., Salamonski, J. J. Exp. Biol. (1984) [Pubmed]
  2. Determination of biogenic amines in fish implicated in food poisoning by micellar electrokinetic capillary chromatography. Su, S.C., Chou, S.S., Chang, P.C., Hwang, D.F. J. Chromatogr. B Biomed. Sci. Appl. (2000) [Pubmed]
  3. Evidence that histamine is the causative toxin of scombroid-fish poisoning. Morrow, J.D., Margolies, G.R., Rowland, J., Roberts, L.J. N. Engl. J. Med. (1991) [Pubmed]
  4. Jamip1 (marlin-1) defines a family of proteins interacting with janus kinases and microtubules. Steindler, C., Li, Z., Algarté, M., Alcover, A., Libri, V., Ragimbeau, J., Pellegrini, S. J. Biol. Chem. (2004) [Pubmed]
  5. Isolation and characterization of novel polymorphic tetra-nucleotide microsatellite markers from the blue marlin, Makaira nigricans. Buonaccorsi, V.P., Graves, J.E. Mol. Ecol. (2000) [Pubmed]
  6. Effects of Ca2+ on oxidative phosphorylation in mitochondria from the thermogenic organ of marlin. O'Brien, J., Block, B.A. J. Exp. Biol. (1996) [Pubmed]
  7. Evolutionary adaptation of muscle power output to environmental temperature: force-velocity characteristics of skinned fibres isolated from antarctic, temperate and tropical marine fish. Johnston, I.A., Altringham, J.D. Pflugers Arch. (1985) [Pubmed]
  8. Cryopreservation of spermatozoa of black marlin, Makaira indica (Teleostei: istiophoridae). van der Straten, K.M., Leung, L.K., Rossini, R., Johnston, S.D. Cryo letters. (2006) [Pubmed]
  9. Expression of sarcoplasmic reticulum Ca(2+)-ATPase isoforms in marlin and swordfish muscle and heater cells. Tullis, A., Block, B.A. Am. J. Physiol. (1996) [Pubmed]
  10. Cloning and characterization of fiber type-specific ryanodine receptor isoforms in skeletal muscles of fish. Franck, J.P., Morrissette, J., Keen, J.E., Londraville, R.L., Beamsley, M., Block, B.A. Am. J. Physiol. (1998) [Pubmed]
  11. Determination of methylmercury in fish using focused microwave digestion following by Cu2+ addition, sodium tetrapropylborate derivatization, n-heptane extraction, and gas chromatography-mass spectrometry. Chen, S.S., Chou, S.S., Hwang, D.F. Journal of chromatography. A. (2004) [Pubmed]
  12. Survey of total mercury in some edible fish and shellfish species collected in Canada in 2002. Dabeka, R., McKenzie, A.D., Forsyth, D.S., Conacher, H.B. Food additives and contaminants. (2004) [Pubmed]
  13. Direct sequencing of mitochondrial DNA detects highly divergent haplotypes in blue marlin (Makaira nigricans). Finnerty, J.R., Block, B.A. Mol. Marine Biol. Biotechnol. (1992) [Pubmed]
  14. Oxygen binding by the blood and hematological effects of capture stress in two big game-fish: mako shark and striped marlin. Wells, R.M., Davie, P.S. Comparative biochemistry and physiology. A, Comparative physiology. (1985) [Pubmed]
  15. Characterization of ryanodine receptor and Ca2+-ATPase isoforms in the thermogenic heater organ of blue marlin (Makaira nigricans). Morrissette, J.M., Franck, J.P., Block, B.A. J. Exp. Biol. (2003) [Pubmed]
  16. Parvalbumin is not responsible for cross-reactivity between tuna and marlin: A case report. Kondo, Y., Komatsubara, R., Nakajima, Y., Yasuda, T., Kakami, M., Tsuge, I., Urisu, A. J. Allergy Clin. Immunol. (2006) [Pubmed]
  17. Role of histidine-related compounds to intracellular buffering in fish skeletal muscle. Abe, H., Dobson, G.P., Hoeger, U., Parkhouse, W.S. Am. J. Physiol. (1985) [Pubmed]
  18. Acclimation and acclimatisation of the equine athlete. Marlin, D.J. International journal of sports medicine. (1998) [Pubmed]
  19. Histochemical and immunohistochemical studies on the origin of the blue marlin heater cell phenotype. Tullis, A., Block, B.A. Tissue & cell. (1997) [Pubmed]
 
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