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Gene Review

Hmx3  -  H6 homeobox 3

Mus musculus

Synonyms: Homeobox protein H6 family member 3, Homeobox protein HMX3, Homeobox protein Nkx-5.1, Nkx-5.1, Nkx5-1, ...
 
 
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High impact information on Hmx3

 

Biological context of Hmx3

 

Anatomical context of Hmx3

 

Co-localisations of Hmx3

 

Regulatory relationships of Hmx3

 

Other interactions of Hmx3

  • The Igf1r and Agc1 loci are syntenic on mouse Chr 7, together with Hmx3, an H6-like locus [11].
  • These data suggest that Nkx5 genes, Pax2 and sek play different roles in the patterning of inner ear structures [10].
  • Mice carrying the Nkx5-1 null mutation exhibit behavioural abnormalities that resemble the typical hyperactivity and circling movements of the shaker/waltzer type mutants [9].

References

  1. Hmx2 homeobox gene control of murine vestibular morphogenesis. Wang, W., Chan, E.K., Baron, S., Van de Water, T., Lufkin, T. Development (2001) [Pubmed]
  2. Inner ear and maternal reproductive defects in mice lacking the Hmx3 homeobox gene. Wang, W., Van De Water, T., Lufkin, T. Development (1998) [Pubmed]
  3. Assignment of the murine Hmx2 and Hmx3 homeobox genes to the distal region of mouse chromosome 7. Wang, W., Lufkin, T. Chromosome Res. (1997) [Pubmed]
  4. Distinct temporal expression of mouse Nkx-5.1 and Nkx-5.2 homeobox genes during brain and ear development. Rinkwitz-Brandt, S., Justus, M., Oldenettel, I., Arnold, H.H., Bober, E. Mech. Dev. (1995) [Pubmed]
  5. Two highly related homeodomain proteins, Nkx5-1 and Nkx5-2, display different DNA binding specificities. Mennerich, D., Hoffmann, S., Hadrys, T., Arnold, H.H., Bober, E. Biol. Chem. (1999) [Pubmed]
  6. Genomic organization and expression analysis of the murine Fam3c gene. Pilipenko, V.V., Reece, A., Choo, D.I., Greinwald, J.H. Gene (2004) [Pubmed]
  7. Hmx: an evolutionary conserved homeobox gene family expressed in the developing nervous system in mice and Drosophila. Wang, W., Lo, P., Frasch, M., Lufkin, T. Mech. Dev. (2000) [Pubmed]
  8. Genetic patterning of embryonic inner ear development. Represa, J., Frenz, D.A., Van De Water, T.R. Acta Otolaryngol. (2000) [Pubmed]
  9. Nkx5-1 controls semicircular canal formation in the mouse inner ear. Hadrys, T., Braun, T., Rinkwitz-Brandt, S., Arnold, H.H., Bober, E. Development (1998) [Pubmed]
  10. Regionalized expression of Nkx5-1, Nkx5-2, Pax2 and sek genes during mouse inner ear development. Rinkwitz-Brandt, S., Arnold, H.H., Bober, E. Hear. Res. (1996) [Pubmed]
  11. Gene homologs on human chromosome 15q21-q26 and a chicken microchromosome identify a new conserved segment. Jones, C.T., Morrice, D.R., Paton, I.R., Burt, D.W. Mamm. Genome (1997) [Pubmed]
 
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