The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Hmx3  -  H6 homeobox 3

Mus musculus

Synonyms: Homeobox protein H6 family member 3, Homeobox protein HMX3, Homeobox protein Nkx-5.1, Nkx-5.1, Nkx5-1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Hmx3


Biological context of Hmx3


Anatomical context of Hmx3


Co-localisations of Hmx3


Regulatory relationships of Hmx3


Other interactions of Hmx3

  • The Igf1r and Agc1 loci are syntenic on mouse Chr 7, together with Hmx3, an H6-like locus [11].
  • These data suggest that Nkx5 genes, Pax2 and sek play different roles in the patterning of inner ear structures [10].
  • Mice carrying the Nkx5-1 null mutation exhibit behavioural abnormalities that resemble the typical hyperactivity and circling movements of the shaker/waltzer type mutants [9].


  1. Hmx2 homeobox gene control of murine vestibular morphogenesis. Wang, W., Chan, E.K., Baron, S., Van de Water, T., Lufkin, T. Development (2001) [Pubmed]
  2. Inner ear and maternal reproductive defects in mice lacking the Hmx3 homeobox gene. Wang, W., Van De Water, T., Lufkin, T. Development (1998) [Pubmed]
  3. Assignment of the murine Hmx2 and Hmx3 homeobox genes to the distal region of mouse chromosome 7. Wang, W., Lufkin, T. Chromosome Res. (1997) [Pubmed]
  4. Distinct temporal expression of mouse Nkx-5.1 and Nkx-5.2 homeobox genes during brain and ear development. Rinkwitz-Brandt, S., Justus, M., Oldenettel, I., Arnold, H.H., Bober, E. Mech. Dev. (1995) [Pubmed]
  5. Two highly related homeodomain proteins, Nkx5-1 and Nkx5-2, display different DNA binding specificities. Mennerich, D., Hoffmann, S., Hadrys, T., Arnold, H.H., Bober, E. Biol. Chem. (1999) [Pubmed]
  6. Genomic organization and expression analysis of the murine Fam3c gene. Pilipenko, V.V., Reece, A., Choo, D.I., Greinwald, J.H. Gene (2004) [Pubmed]
  7. Hmx: an evolutionary conserved homeobox gene family expressed in the developing nervous system in mice and Drosophila. Wang, W., Lo, P., Frasch, M., Lufkin, T. Mech. Dev. (2000) [Pubmed]
  8. Genetic patterning of embryonic inner ear development. Represa, J., Frenz, D.A., Van De Water, T.R. Acta Otolaryngol. (2000) [Pubmed]
  9. Nkx5-1 controls semicircular canal formation in the mouse inner ear. Hadrys, T., Braun, T., Rinkwitz-Brandt, S., Arnold, H.H., Bober, E. Development (1998) [Pubmed]
  10. Regionalized expression of Nkx5-1, Nkx5-2, Pax2 and sek genes during mouse inner ear development. Rinkwitz-Brandt, S., Arnold, H.H., Bober, E. Hear. Res. (1996) [Pubmed]
  11. Gene homologs on human chromosome 15q21-q26 and a chicken microchromosome identify a new conserved segment. Jones, C.T., Morrice, D.R., Paton, I.R., Burt, D.W. Mamm. Genome (1997) [Pubmed]
WikiGenes - Universities