Gene Review:
Pax2 - paired box 2
Mus musculus
Synonyms:
Opdc, Paired box protein Pax-2, Pax-2
- The secreted frizzled related protein 2 (SFRP2) gene is a target of the Pax2 transcription factor. Brophy, P.D., Lang, K.M., Dressler, G.R. J. Biol. Chem. (2003)
- Pax2 contributes to inner ear patterning and optic nerve trajectory. Torres, M., Gómez-Pardo, E., Gruss, P. Development (1996)
- An inducible mouse model for PAX2-dependent glomerular disease: insights into a complex pathogenesis. Wagner, K.D., Wagner, N., Guo, J.K., Elger, M., Dallman, M.J., Bugeon, L., Schedl, A. Curr. Biol. (2006)
- Pax2 expression and retinal morphogenesis in the normal and Krd mouse. Otteson, D.C., Shelden, E., Jones, J.M., Kameoka, J., Hitchcock, P.F. Dev. Biol. (1998)
- Reduced Pax2 gene dosage increases apoptosis and slows the progression of renal cystic disease. Ostrom, L., Tang, M.J., Gruss, P., Dressler, G.R. Dev. Biol. (2000)
- Mesenchymal to epithelial conversion in rat metanephros is induced by LIF. Barasch, J., Yang, J., Ware, C.B., Taga, T., Yoshida, K., Erdjument-Bromage, H., Tempst, P., Parravicini, E., Malach, S., Aranoff, T., Oliver, J.A. Cell (1999)
- Deregulation of Pax-2 expression in transgenic mice generates severe kidney abnormalities. Dressler, G.R., Wilkinson, J.E., Rothenpieler, U.W., Patterson, L.T., Williams-Simons, L., Westphal, H. Nature (1993)
- Nephric lineage specification by Pax2 and Pax8. Bouchard, M., Souabni, A., Mandler, M., Neubüser, A., Busslinger, M. Genes Dev. (2002)
- Cooperation of Pax2 and Pax5 in midbrain and cerebellum development. Urbánek, P., Fetka, I., Meisler, M.H., Busslinger, M. Proc. Natl. Acad. Sci. U.S.A. (1997)
- The mouse Pax2(1Neu) mutation is identical to a human PAX2 mutation in a family with renal-coloboma syndrome and results in developmental defects of the brain, ear, eye, and kidney. Favor, J., Sandulache, R., Neuhäuser-Klaus, A., Pretsch, W., Chatterjee, B., Senft, E., Wurst, W., Blanquet, V., Grimes, P., Spörle, R., Schughart, K. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Lmx1b is essential for Fgf8 and Wnt1 expression in the isthmic organizer during tectum and cerebellum development in mice. Guo, C., Qiu, H.Y., Huang, Y., Chen, H., Yang, R.Q., Chen, S.D., Johnson, R.L., Chen, Z.F., Ding, Y.Q. Development (2007)
- Pax2 and pax8 regulate branching morphogenesis and nephron differentiation in the developing kidney. Narlis, M., Grote, D., Gaitan, Y., Boualia, S.K., Bouchard, M. J. Am. Soc. Nephrol. (2007)
- Retinal pigmented epithelium determination requires the redundant activities of Pax2 and Pax6. Bäumer, N., Marquardt, T., Stoykova, A., Spieler, D., Treichel, D., Ashery-Padan, R., Gruss, P. Development (2003)
- Lhx1 and Lhx5 maintain the inhibitory-neurotransmitter status of interneurons in the dorsal spinal cord. Pillai, A., Mansouri, A., Behringer, R., Westphal, H., Goulding, M. Development (2007)
- Pax2 expression occurs in renal medullary epithelial cells in vivo and in cell culture, is osmoregulated, and promotes osmotic tolerance. Cai, Q., Dmitrieva, N.I., Ferraris, J.D., Brooks, H.L., van Balkom, B.W., Burg, M. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Regulation of c-Ret in the developing kidney is responsive to Pax2 gene dosage. Clarke, J.C., Patel, S.R., Raymond, R.M., Andrew, S., Robinson, B.G., Dressler, G.R., Brophy, P.D. Hum. Mol. Genet. (2006)
- PAX8, a human paired box gene: isolation and expression in developing thyroid, kidney and Wilms' tumors. Poleev, A., Fickenscher, H., Mundlos, S., Winterpacht, A., Zabel, B., Fidler, A., Gruss, P., Plachov, D. Development (1992)
- PAX2 inactivation enhances cisplatin-induced apoptosis in renal carcinoma cells. Hueber, P.A., Waters, P., Clarke, P., Eccles, M., Goodyer, P. Kidney Int. (2006)
- Pax2 and homeodomain proteins cooperatively regulate a 435 bp enhancer of the mouse Pax5 gene at the midbrain-hindbrain boundary. Pfeffer, P.L., Bouchard, M., Busslinger, M. Development (2000)
- Two Pax2/5/8-binding sites in Engrailed2 are required for proper initiation of endogenous mid-hindbrain expression. Li Song, D., Joyner, A.L. Mech. Dev. (2000)
- Regionalized expression of Nkx5-1, Nkx5-2, Pax2 and sek genes during mouse inner ear development. Rinkwitz-Brandt, S., Arnold, H.H., Bober, E. Hear. Res. (1996)
- Functional equivalence of the transcription factors Pax2 and Pax5 in mouse development. Bouchard, M., Pfeffer, P., Busslinger, M. Development (2000)
- Spatial specification of mammalian eye territories by reciprocal transcriptional repression of Pax2 and Pax6. Schwarz, M., Cecconi, F., Bernier, G., Andrejewski, N., Kammandel, B., Wagner, M., Gruss, P. Development (2000)
- Lim 1 is required for nephric duct extension and ureteric bud morphogenesis. Pedersen, A., Skjong, C., Shawlot, W. Dev. Biol. (2005)
- Hox11 paralogous genes are essential for metanephric kidney induction. Wellik, D.M., Hawkes, P.J., Capecchi, M.R. Genes Dev. (2002)
- Hes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain. Hirata, H., Tomita, K., Bessho, Y., Kageyama, R. EMBO J. (2001)
- Otx genes are required for tissue specification in the developing eye. Martinez-Morales, J.R., Signore, M., Acampora, D., Simeone, A., Bovolenta, P. Development (2001)
- Identification of Pax2-regulated genes by expression profiling of the mid-hindbrain organizer region. Bouchard, M., Grote, D., Craven, S.E., Sun, Q., Steinlein, P., Busslinger, M. Development (2005)
- Aphakia (ak), a mouse mutation affecting early eye development: fine mapping, consideration of candidate genes and altered Pax6 and Six3 gene expression pattern. Grimm, C., Chatterjee, B., Favor, J., Immervoll, T., Löster, J., Klopp, N., Sandulache, R., Graw, J. Dev. Genet. (1998)
- Spatially and temporally restricted expression of Pax2 during murine neurogenesis. Nornes, H.O., Dressler, G.R., Knapik, E.W., Deutsch, U., Gruss, P. Development (1990)
- Regulation of ureteric bud outgrowth by Pax2-dependent activation of the glial derived neurotrophic factor gene. Brophy, P.D., Ostrom, L., Lang, K.M., Dressler, G.R. Development (2001)