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Gene Review

AP2B1  -  adaptor-related protein complex 2, beta 1...

Homo sapiens

Synonyms: ADTB2, AP-2 complex subunit beta, AP105B, AP2-BETA, Adaptor protein complex AP-2 subunit beta, ...
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Disease relevance of AP2B1

  • Characterization of a new member of the human beta-adaptin gene family from chromosome 22q12, a candidate meningioma gene [1].

High impact information on AP2B1


Biological context of AP2B1


Anatomical context of AP2B1

  • Differential expression experiments of beta-adaptin, alpha-adaptin, SR-AI, and SR-BI in RAW (macrophages) and EOC (microglia) cells were performed according to dosage and exposure time to amyloid-beta [7].
  • Expression of a novel beta adaptin subunit mRNA splice variant in human testes [8].

Regulatory relationships of AP2B1


Other interactions of AP2B1

  • We have determined human chromosomal locations of genes for a large AP2 beta (CLAPB1) and a medium (CLAPM1) AP subunit and of a novel clathrin-binding protein, VCP, that binds clathrin simultaneously with APs [5].
  • The interaction between ATM and beta-adaptin was confirmed in vitro, and coimmunoprecipitation and colocalization studies show that the proteins also associate in vivo [4].
  • ATM also interacts in vitro with beta-NAP, a neuronal-specific beta-adaptin homolog that was identified as an autoantigen in a patient with cerebellar degeneration [4].
  • Like AP180, auxilin also directly interacts with the ear domain of beta-adaptin [10].

Analytical, diagnostic and therapeutic context of AP2B1

  • The gene for the CLAPB1 large subunit was mapped to 17q11.2-q12 by PCR amplification of an AP2 beta fragment from a panel of rodent-human hybrid DNAs [5].
  • Under these conditions, RT-PCR assays show that beta-adaptin mRNA is normally synthesized, reason why protein translation or protein structure of beta-adaptin might be altered [7].


  1. Characterization of a new member of the human beta-adaptin gene family from chromosome 22q12, a candidate meningioma gene. Peyrard, M., Fransson, I., Xie, Y.G., Han, F.Y., Ruttledge, M.H., Swahn, S., Collins, J.E., Dunham, I., Collins, V.P., Dumanski, J.P. Hum. Mol. Genet. (1994) [Pubmed]
  2. A coat subunit of Golgi-derived non-clathrin-coated vesicles with homology to the clathrin-coated vesicle coat protein beta-adaptin. Serafini, T., Stenbeck, G., Brecht, A., Lottspeich, F., Orci, L., Rothman, J.E., Wieland, F.T. Nature (1991) [Pubmed]
  3. In vitro binding of the asialoglycoprotein receptor to the beta adaptin of plasma membrane coated vesicles. Beltzer, J.P., Spiess, M. EMBO J. (1991) [Pubmed]
  4. ATM binds to beta-adaptin in cytoplasmic vesicles. Lim, D.S., Kirsch, D.G., Canman, C.E., Ahn, J.H., Ziv, Y., Newman, L.S., Darnell, R.B., Shiloh, Y., Kastan, M.B. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  5. Chromosome localization of human genes for clathrin adaptor polypeptides AP2 beta and AP50 and the clathrin-binding protein, VCP. Druck, T., Gu, Y., Prabhala, G., Cannizzaro, L.A., Park, S.H., Huebner, K., Keen, J.H. Genomics (1995) [Pubmed]
  6. Protein kinase C activates human lipocalin-type prostaglandin D synthase gene expression through de-repression of notch-HES signaling and enhancement of AP-2 beta function in brain-derived TE671 cells. Fujimori, K., Kadoyama, K., Urade, Y. J. Biol. Chem. (2005) [Pubmed]
  7. beta-adaptin: Key molecule for microglial scavenger receptor function under oxidative stress. Manzano-Le??n, N., Delgado-Coello, B., Guaderrama-D??az, M., Mas-Oliva, J. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  8. Expression of a novel beta adaptin subunit mRNA splice variant in human testes. Zhang, X.D., Yin, L.L., Zheng, Y., Lu, L., Zhou, Z.M., Sha, J.H. Asian J. Androl. (2005) [Pubmed]
  9. Src-dependent phosphorylation of beta2-adaptin dissociates the beta-arrestin-AP-2 complex. Fessart, D., Simaan, M., Zimmerman, B., Comeau, J., Hamdan, F.F., Wiseman, P.W., Bouvier, M., Laporte, S.A. J. Cell. Sci. (2007) [Pubmed]
  10. Molecular and functional characterization of clathrin- and AP-2-binding determinants within a disordered domain of auxilin. Scheele, U., Alves, J., Frank, R., Duwel, M., Kalthoff, C., Ungewickell, E. J. Biol. Chem. (2003) [Pubmed]
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