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Gene Review

ASGR1  -  asialoglycoprotein receptor 1

Homo sapiens

Synonyms: ASGP-R 1, ASGPR, ASGPR 1, ASGPR1, Asialoglycoprotein receptor 1, ...
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Disease relevance of ASGR1


High impact information on ASGR1


Chemical compound and disease context of ASGR1


Biological context of ASGR1


Anatomical context of ASGR1


Associations of ASGR1 with chemical compounds


Physical interactions of ASGR1


Other interactions of ASGR1


Analytical, diagnostic and therapeutic context of ASGR1


  1. Role of the asialoglycoprotein receptor in binding and entry of hepatitis C virus structural proteins in cultured human hepatocytes. Saunier, B., Triyatni, M., Ulianich, L., Maruvada, P., Yen, P., Kohn, L.D. J. Virol. (2003) [Pubmed]
  2. Antisense oligonucleotides targeted against asialoglycoprotein receptor 1 block human hepatitis B virus replication. Yang, J., Bo, X.C., Ding, X.R., Dai, J.M., Zhang, M.L., Wang, X.H., Wang, S.Q. J. Viral Hepat. (2006) [Pubmed]
  3. The N-glycans determine the differential blood clearance and hepatic uptake of human immunoglobulin (Ig)A1 and IgA2 isotypes. Rifai, A., Fadden, K., Morrison, S.L., Chintalacharuvu, K.R. J. Exp. Med. (2000) [Pubmed]
  4. The H1 and H2 polypeptides associate to form the asialoglycoprotein receptor in human hepatoma cells. Bischoff, J., Libresco, S., Shia, M.A., Lodish, H.F. J. Cell Biol. (1988) [Pubmed]
  5. T-cell-directed hepatocyte damage in autoimmune chronic active hepatitis. Wen, L., Peakman, M., Lobo-Yeo, A., McFarlane, B.M., Mowat, A.P., Mieli-Vergani, G., Vergani, D. Lancet (1990) [Pubmed]
  6. Insertion of a multispanning membrane protein occurs sequentially and requires only one signal sequence. Wessels, H.P., Spiess, M. Cell (1988) [Pubmed]
  7. The asialoglycoprotein receptor internalizes and recycles independently of the transferrin and insulin receptors. Ciechanover, A., Schwartz, A.L., Lodish, H.F. Cell (1983) [Pubmed]
  8. Targeted transfection and expression of hepatitis B viral DNA in human hepatoma cells. Liang, T.J., Makdisi, W.J., Sun, S., Hasegawa, K., Zhang, Y., Wands, J.R., Wu, C.H., Wu, G.Y. J. Clin. Invest. (1993) [Pubmed]
  9. Recognition of complex oligosaccharides by the multi-subunit asialoglycoprotein receptor. Lodish, H.F. Trends Biochem. Sci. (1991) [Pubmed]
  10. Apical expression of functional asialoglycoprotein receptor in the human intestinal cell line HT-29. Mu, J.Z., Gordon, M., Shao, J.S., Alpers, D.H. Gastroenterology (1997) [Pubmed]
  11. A novel, orally administered nucleoside analogue, OGT 719, inhibits the liver invasive growth of a human colorectal tumor, C170HM2. Rohlff, C., Watson, S.A., Morris, T.M., Skelton, L., Jackman, A.L., Page, M.J. Cancer Res. (1999) [Pubmed]
  12. Cellular pathways of galactose-terminal ligand movement in a cloned human hepatoma cell line. Simmons, C.F., Schwartz, A.L. Mol. Pharmacol. (1984) [Pubmed]
  13. Pseudotype formation of Moloney murine leukemia virus with Sendai virus glycoprotein F. Spiegel, M., Bitzer, M., Schenk, A., Rossmann, H., Neubert, W.J., Seidler, U., Gregor, M., Lauer, U. J. Virol. (1998) [Pubmed]
  14. Recycling of the asialoglycoprotein receptor and the effect of lysosomotropic amines in hepatoma cells. Schwartz, A.L., Bolognesi, A., Fridovich, S.E. J. Cell Biol. (1984) [Pubmed]
  15. Quantitative assessment of hepatocellular function through in vivo radioreceptor imaging with technetium 99m galactosyl human serum albumin. Kudo, M., Todo, A., Ikekubo, K., Yamamoto, K., Vera, D.R., Stadalnik, R.C. Hepatology (1993) [Pubmed]
  16. An internal signal sequence: the asialoglycoprotein receptor membrane anchor. Spiess, M., Lodish, H.F. Cell (1986) [Pubmed]
  17. Sequence of human asialoglycoprotein receptor cDNA. An internal signal sequence for membrane insertion. Spiess, M., Schwartz, A.L., Lodish, H.F. J. Biol. Chem. (1985) [Pubmed]
  18. Crystal structure of the carbohydrate recognition domain of the H1 subunit of the asialoglycoprotein receptor. Meier, M., Bider, M.D., Malashkevich, V.N., Spiess, M., Burkhard, P. J. Mol. Biol. (2000) [Pubmed]
  19. Assignment of human asialoglycoprotein receptor gene (ASGR1) to chromosome 17p11-13. Sanford, J.P., Eddy, R.L., Doyle, D., Shows, T.B. Genomics (1991) [Pubmed]
  20. In vitro binding of the asialoglycoprotein receptor to the beta adaptin of plasma membrane coated vesicles. Beltzer, J.P., Spiess, M. EMBO J. (1991) [Pubmed]
  21. Cytotoxic effect induced by retinoic acid loaded into galactosyl-sphingosine containing liposomes on human hepatoma cell lines. D??az, C., Vargas, E., G??tjens-Boniche, O. International journal of pharmaceutics. (2006) [Pubmed]
  22. I-domain-containing integrins serve as pilus receptors for Neisseria gonorrhoeae adherence to human epithelial cells. Edwards, J.L., Apicella, M.A. Cell. Microbiol. (2005) [Pubmed]
  23. Role of thyroglobulin endocytic pathways in the control of thyroid hormone release. Marinò, M., McCluskey, R.T. Am. J. Physiol., Cell Physiol. (2000) [Pubmed]
  24. The two subunits of the human asialoglycoprotein receptor have different fates when expressed alone in fibroblasts. Shia, M.A., Lodish, H.F. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  25. The position of cysteine relative to the transmembrane domain is critical for palmitoylation of H1, the major subunit of the human asialoglycoprotein receptor. Yik, J.H., Weigel, P.H. J. Biol. Chem. (2002) [Pubmed]
  26. Endocytosis by the asialoglycoprotein receptor is independent of cytoplasmic serine residues. Geffen, I., Fuhrer, C., Spiess, M. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  27. The effect of ethanol on asialoglycoprotein receptor-mediated phagocytosis of apoptotic cells by rat hepatocytes. McVicker, B.L., Tuma, D.J., Kubik, J.A., Hindemith, A.M., Baldwin, C.R., Casey, C.A. Hepatology (2002) [Pubmed]
  28. In situ 125I-labelling of endosome proteins with lactoperoxidase conjugates. Watts, C. EMBO J. (1984) [Pubmed]
  29. Presence of beta-linked GalNAc residues on N-glycans of human thyroglobulin. Takeya, A., Hosomi, O., Nishijima, H., Ohe, Y., Sugahara, K., Sagi, M., Yamazaki, K., Hayakawa, H., Takeshita, H., Sasaki, C., Kogure, T., Mukai, T. Life Sci. (2007) [Pubmed]
  30. c-src tyrosine kinase is associated with the asialoglycoprotein receptor in human hepatoma cells. Parker, A., Fallon, R.J. Mol. Cell Biol. Res. Commun. (2001) [Pubmed]
  31. Demographics of anti-asialoglycoprotein receptor autoantibodies in autoimmune hepatitis. Treichel, U., McFarlane, B.M., Seki, T., Krawitt, E.L., Alessi, N., Stickel, F., McFarlane, I.G., Kiyosawa, K., Furuta, S., Freni, M.A. Gastroenterology (1994) [Pubmed]
  32. Distribution of asialoglycoprotein receptor in human hepatocellular carcinoma. Hyodo, I., Mizuno, M., Yamada, G., Tsuji, T. Liver (1993) [Pubmed]
  33. Conformational changes in the receptors for epidermal growth factor and asialoglycoproteins induced by the mildly acidic pH found in endocytic vesicles. DiPaola, M., Maxfield, F.R. J. Biol. Chem. (1984) [Pubmed]
  34. Functional mapping of regional liver asialoglycoprotein receptor amount from single blood sample and SPECT. Shuke, N., Okizaki, A., Kino, S., Sato, J., Ishikawa, Y., Zhao, C., Kinuya, S., Watanabe, N., Yokoyama, K., Aburano, T. J. Nucl. Med. (2003) [Pubmed]
  35. Autoantibodies to asialoglycoprotein receptor in chronic hepatitis C patients. Husa, P., Chalupa, P., Stroblová, H., Husová, L., Slesinger, P., Zajíc, J. Acta Virol. (2001) [Pubmed]
  36. One step isolation of bovine asialoglycoprotein receptor and its characterization by sequence analysis and MALDI mass spectrometry. Seimetz, D., Frei, E., Schnölzer, M., Kempf, T., Wiessler, M. Biosci. Rep. (1999) [Pubmed]
  37. Development of syngeneic monoclonal anti-idiotype antibodies to mouse monoclonal anti-asialoglycoprotein receptor antibody. Hirai, M., Mizuno, M., Morisue, Y., Yoshioka, M., Shimada, M., Nasu, J., Okada, H., Shimomura, H., Yamamoto, K., Tsuji, T. Acta Med. Okayama (2002) [Pubmed]
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