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Chemical Compound Review

Cobalt-60     cobalt

Synonyms: Co-60, AC1L1VCE, 60Co, 10198-40-0, UNII-5C8182XDPZ, ...
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Disease relevance of cobalt


High impact information on cobalt

  • The survival of thyroid allografts in mice was prolonged by either holding the grafts in vitro culture for 20 to 27 days or by cobalt-60 irradiation of the donor 2 days before transplantation with or without the intravenous injection of colloidal carbon just before removing the thyroid from the donor [6].
  • Letter: Cobalt, cardiomyopathy, and dialysis [7].
  • Similar analysis of a separate series of cell strains, derived from foci induced by cobalt-60, revealed four patterns of loss of heterozygosity, only two of which had been found with those induced by MNU [8].
  • BAEC in serum-free media were irradiated with a cobalt-60 Gammacell 220 and the cell supernatants were assayed for chemotactic activity for human neutrophils in a Boyden chamber [9].
  • To investigate this discrepancy, nitrogen-saturated aqueous solutions containing 15 mM DMPO were cobalt-60 gamma irradiated (dose rate = 223 Gy/min) for periods of 0.25-6 min, and ESR absorption spectra were observed approximately 30 s after irradiation [10].

Chemical compound and disease context of cobalt


Biological context of cobalt


Anatomical context of cobalt


Associations of cobalt with other chemical compounds


Gene context of cobalt


Analytical, diagnostic and therapeutic context of cobalt

  • All patients underwent clinical and audiologic evaluations varying from 6 to 48 months (mean, 20 months) after stereotactic radiosurgery performed with use of the 201 source cobalt 60 gamma unit [36].
  • A total of 72 animals were randomly assigned to four treatment groups (18/group) as follows: (1) 10 G; (2) sham exposed (null energized field) (approximately 20 mG); (3) ambient controls (<1 mG); and (4) positive controls (5 Gy whole body irradiation from Cobalt-60, 4 days before initiation of exposure) [37].
  • This machine contains a high intensity cobalt 60 remote afterloading cycling source used for intracavitary brachytherapy [38].
  • PATIENTS AND METHODS: Three female patients who had developed urge-incontinence after a Wertheim operation and combined brachy-teletherapy with cobalt-60 and afterloading and did not respond to various drug therapies, were treated with HBO to a maximum of 40 applications [39].
  • Even in patients who received doses of radiation up to 66 Cobalt Gy equivalent through nondiseased (temporal lobe) brain tissue, memory and cognitive functioning remained stable for up to 5 years after treatment [40].


  1. Letter: Cobalt intoxication in uraemic myocardiopathy? Lins, L.E., Pehrsson, K. Lancet (1976) [Pubmed]
  2. An experimental animal model of granulomatous bowel disease. Mitchell, I.C., Turk, J.L. Gut (1989) [Pubmed]
  3. Primary radiotherapy of prolactinomas. Eight- to 15-year follow-up. Mehta, A.E., Reyes, F.I., Faiman, C. Am. J. Med. (1987) [Pubmed]
  4. Comparison of mycobacterial granulomas in guinea-pig lymph nodes. Narayanan, R.B., Badenoch-Jones, P., Curtis, J., Turk, J.L. J. Pathol. (1982) [Pubmed]
  5. Ocular melanoma: total dose and dose rate effects with Co-60 plaque therapy. Beitler, J.J., McCormick, B., Ellsworth, R.M., Abramson, D.H., Anderson, L.L., Loffredo, C. Radiology. (1990) [Pubmed]
  6. Activation of transplant immunity: effect of donor leukocytes on thyroid allograft rejection. Talmage, D.W., Dart, G., Radovich, J., Lafferty, K.J. Science (1976) [Pubmed]
  7. Letter: Cobalt, cardiomyopathy, and dialysis. Wardle, E.N. Lancet (1976) [Pubmed]
  8. Malignant transformation of human fibroblast cell strain MSU-1.1 by N-methyl-N-nitrosourea: evidence of elimination of p53 by homologous recombination. Boley, S.E., McManus, T.P., Maher, V.M., McCormick, J.J. Cancer Res. (2000) [Pubmed]
  9. Generation of lipid neutrophil chemoattractant by irradiated bovine aortic endothelial cells. Matzner, Y., Cohn, M., Hyam, E., Razin, E., Fuks, Z., Buchanan, M.R., Haas, T.A., Vlodavsky, I., Eldor, A. J. Immunol. (1988) [Pubmed]
  10. The role of the DMPO-hydrated electron spin adduct in DMPO-*OH spin trapping. Madden, K.P., Taniguchi, H. Free Radic. Biol. Med. (2001) [Pubmed]
  11. PC-10 immunostaining of proliferating cell nuclear antigen in posterior uveal melanoma. Enucleation versus enucleation postirradiation groups. Pe'er, J., Gnessin, H., Shargal, Y., Livni, N. Ophthalmology (1994) [Pubmed]
  12. High-Level Resistance to Cobalt and Nickel but Probably No Transenvelope Efflux: Metal Resistance in the Cuban Serratia marcescens Strain C-1. Marrero, J., Auling, G., Coto, O., Nies, D.H. Microb. Ecol. (2007) [Pubmed]
  13. Iridium-192 versus cobalt-60 boost in 3-7 cm breast cancer treated by irradiation alone: final results of a randomized trial. Fourquet, A., Campana, F., Mosseri, V., Cetingoz, R., Luciani, S., Labib, A., Asselain, B., Vilcoq, J.R. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. (1995) [Pubmed]
  14. Changes in height of choroidal melanomas after plaque therapy. Abramson, D.H., Servodidio, C.A., McCormick, B., Fass, D., Zang, E. The British journal of ophthalmology. (1990) [Pubmed]
  15. Effects of PI3K and p42/p44 MAPK on overexpression of vascular endothelial growth factor in hepatocellular carcinoma. Huang, G.W., Yang, L.Y., Lu, W.Q. World J. Gastroenterol. (2004) [Pubmed]
  16. The response of a human malignant melanoma cell line to high LET radiation. Thomson, L.F., Smith, A.R., Humphrey, R.M. Radiology. (1975) [Pubmed]
  17. Enzyme Deactivation Due to Metal-Ion Dissociation during Turnover of the Cobalt-beta-Lactamase Catalyzed Hydrolysis of beta-Lactams. Badarau, A., Page, M.I. Biochemistry (2006) [Pubmed]
  18. Malignant melanoma of the eye: treatment of posterior uveal lesions by Co-60 plaque radiotherapy versus enucleation. Markoe, A.M., Brady, L.W., Shields, J.A., Augsburger, J.J., Micaily, B., Damsker, J.I., Day, J.L., Gamel, J.W. Radiology. (1985) [Pubmed]
  19. Effects of prenatal irradiation on fetal, neonate, and young adult murine hemopoiesis. Weinberg, S.R. Int. J. Radiat. Oncol. Biol. Phys. (1983) [Pubmed]
  20. Bipolar origin of synaptic inputs to sustained OFF-ganglion cells in the mudpuppy retina. Arkin, M.S., Miller, R.F. J. Neurophysiol. (1988) [Pubmed]
  21. Transparent plastic replicas of cobalt-60 applicators for the management of choroid tumors. Gonzalez, M.O., Drouilhet, J.H., Ruiz, R.S., Cundiff, J.H. Radiology. (1981) [Pubmed]
  22. Regional pulmonary function after irradiation of the canine lung: radionuclide evaluation. Vieras, F., Bradley, E.W., Alderson, P.O., Jacobus, J.P., Grissom, M.P. Radiology. (1983) [Pubmed]
  23. Involvement of energy metabolism in the production of 'bystander effects' by radiation. Mothersill, C., Stamato, T.D., Perez, M.L., Cummins, R., Mooney, R., Seymour, C.B. Br. J. Cancer (2000) [Pubmed]
  24. Impact of local tumor relapse on patient survival after cobalt 60 plaque radiotherapy. Vrabec, T.R., Augsburger, J.J., Gamel, J.W., Brady, L.W., Hernandez, C., Woodleigh, R. Ophthalmology (1991) [Pubmed]
  25. Late effects of 50 MeV d leads to Be neutron and cobalt-60 irradiation of rhesus monkey cervical spinal cord. Stephens, L.C., Hussey, D.H., Raulston, G.L., Jardine, J.H., Gray, K.N., Almond, P.R. Int. J. Radiat. Oncol. Biol. Phys. (1983) [Pubmed]
  26. Modification of a standard cobalt-60 unit for total body irradiation at 150 cm SSD. Peters, V.G., Herer, A.S. Int. J. Radiat. Oncol. Biol. Phys. (1984) [Pubmed]
  27. Granulocyte colony-stimulating factor and amifostine (Ethyol) synergize to enhance hemopoietic reconstitution and increase survival in irradiated animals. Patchen, M.L., MacVittie, T.J. Semin. Oncol. (1994) [Pubmed]
  28. Diastereoselective cobalt-catalyzed reductive aldol cyclizations using diethylzinc as the stoichiometric reductant. Lam, H.W., Joensuu, P.M., Murray, G.J., Fordyce, E.A., Prieto, O., Luebbers, T. Org. Lett. (2006) [Pubmed]
  29. The effect of 2-[(aminopropyl)amino] ethanethiol (WR-1065) on radiation induced DNA double strand damage and repair in V79 cells. Sigdestad, C.P., Treacy, S.H., Knapp, L.A., Grdina, D.J. Br. J. Cancer (1987) [Pubmed]
  30. Irradiation of the mouse lip mucosa with cobalt-60 gamma rays and d(50)+Be neutrons; combination with bleomycin. Scalliet, P., Landuyt, W., Van der Schueren, E., Wambersie, A. Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]. (1990) [Pubmed]
  31. The effect of gamma radiation on recombination frequency in Caenorhabditis elegans. Kim, J.S., Rose, A.M. Genome (1987) [Pubmed]
  32. Quantitative analysis of calcitonin gene-related peptide- and neuropeptide Y-immunoreactive nerve fibers in mesenteric blood vessels of rats irradiated with cobalt-60 gamma rays. Zhang, C.G., Cai, W.Q., Li, Y., Huang, W.Q., Su, H.C. Radiat. Res. (1998) [Pubmed]
  33. Characteristics of an Albumin Cobalt Binding Test for assessment of acute coronary syndrome patients: a multicenter study. Christenson, R.H., Duh, S.H., Sanhai, W.R., Wu, A.H., Holtman, V., Painter, P., Branham, E., Apple, F.S., Murakami, M., Morris, D.L. Clin. Chem. (2001) [Pubmed]
  34. Ischemia-modified albumin improves the usefulness of standard cardiac biomarkers for the diagnosis of myocardial ischemia in the emergency department setting. Anwaruddin, S., Januzzi, J.L., Baggish, A.L., Lewandrowski, E.L., Lewandrowski, K.B. Am. J. Clin. Pathol. (2005) [Pubmed]
  35. Variation in the expression of p53, c-myc, and bcl-2 oncoproteins in individual patient cultures of normal urothelium exposed to cobalt 60 gamma-rays and N-nitrosodiethanolamine. Harney, J.V., Seymour, C.B., Murphy, D.M., Mothersill, C. Cancer Epidemiol. Biomarkers Prev. (1995) [Pubmed]
  36. Cranial nerve preservation after stereotactic radiosurgery for small acoustic tumors. Ogunrinde, O.K., Lunsford, L.D., Flickinger, J.C., Kondziolka, D.S. Arch. Neurol. (1995) [Pubmed]
  37. Exposure to 60 Hz magnetic fields does not alter clinical progression of LGL leukemia in Fischer rats. Sasser, L.B., Morris, J.E., Miller, D.L., Rafferty, C.N., Ebi, K.L., Anderson, L.E. Carcinogenesis (1996) [Pubmed]
  38. High-dose-rate afterloading brachytherapy in carcinoma of the uterine cervix. Utley, J.F., von Essen, C.F., Horn, R.A., Moeller, J.H. Int. J. Radiat. Oncol. Biol. Phys. (1984) [Pubmed]
  39. Management of postoperative radiation injury of the urinary bladder by hyperbaric oxygen (HBO). Peusch-Dreyer, D., Dreyer, K.H., Müller, C.D., Carl, U. Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]. (1998) [Pubmed]
  40. Neuropsychological function in adults after high dose fractionated radiation therapy of skull base tumors. Glosser, G., McManus, P., Munzenrider, J., Austin-Seymour, M., Fullerton, B., Adams, J., Urie, M.M. Int. J. Radiat. Oncol. Biol. Phys. (1997) [Pubmed]
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