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MAP1A  -  microtubule-associated protein 1A

Homo sapiens

Synonyms: MAP-1A, MAP1L, MTAP1A, Microtubule-associated protein 1A, Proliferation-related protein p80
 
 
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Disease relevance of MAP1A

 

High impact information on MAP1A

 

Biological context of MAP1A

  • These results suggest that RFX1 and 3 are pivotal factors in down-regulation of the MAP1A 5' promoter in non-neuronal cells [7].
  • Further investigation of other areas of MAP1A revealed a protein domain, capable of autonomously binding to microtubules, which bears no homology to any previously described microtubule-binding sequence [8].
  • The gene of this cDNA was assigned to human chromosome 15 that has a syntenic region of mouse chromosome 2, where the mouse MAP1A gene has been assigned [9].
  • The exon/intron organization underlying the alternative transcripts and the N-terminal amino acid sequence of the putative truncated MAP1B isoforms resemble those of MAP1A, providing further evidence for an evolutionary relationship [10].
  • Mammalian genomes usually contain three family members, MAP1A, MAP1B and a shorter, more recently identified gene called MAP1S [11].
 

Anatomical context of MAP1A

  • Microtubule-associated protein MAP1A is expressed abundantly in mature neurons and is necessary for maintenance of neuronal morphology and localization of some molecules in association with the microtubule-based cytoskeleton [7].
  • When the MAP1A microtubule-binding domain was co-expressed in cultured cell lines together with MAP2c, the MAP1A microtubule-binding domain was able to bind to the MAP2c-induced microtubule bundles [8].
  • Less is known about MAP1A, but it is also enriched in dendrites at input locations, including PSDs where MAP1A associates with channel complexes and the calcium sensor caldendrin [12].
  • Microtubule-associated proteins 1A (MAP1A) and MAP1B are abundant neuronal MAPs thought to be involved in neurite formation and stabilization [13].
  • An increase in MAP1A immunoreactivity was evident in the perikarya of the dentate gyrus at 30 min postictal, whereas MAP2 immunoreactivity decreased [14].
 

Associations of MAP1A with chemical compounds

 

Physical interactions of MAP1A

 

Other interactions of MAP1A

 

Analytical, diagnostic and therapeutic context of MAP1A

  • MAP1B heavy chain (HC) and light chain (LC1), as well as the light chain of MAP1A (LC2), were prepared in purified form for use as standards and/or immunogens for generation of antibodies for immunoblotting [22].
  • Using a solid-phase immunoassay we show that MAP1A binds in a dose-dependent manner to both G-actin and F-actin [23].
  • Addition of MAP1A to F-actin causes gelation of F-actin and SDS-PAGE analysis shows that MAP1A co-sediments with the gelled network, under conditions where F-actin alone does not pellet [23].
  • Western blotting and ELISA showed that MAP1A protein levels increased during differentiation [2].
  • By immunofluorescent confocal microscopy, MAP1A was detected in the mitotic spindle of undifferentiated cells but was not evident in association with the interphase microtubules in most cells [2].

References

  1. Microtubule-associated proteins (MAPs) in the peripheral nervous system during development and regeneration. Nunez, J., Fischer, I. J. Mol. Neurosci. (1997) [Pubmed]
  2. Accumulation of microtubule-associated protein 1A (MAP1A) in differentiating P19 embryonal carcinoma cells. Vaillant, A.R., Brown, D.L. Biochem. Cell Biol. (1995) [Pubmed]
  3. Microtubule-associated protein 1A is a modifier of tubby hearing (moth1). Ikeda, A., Zheng, Q.Y., Zuberi, A.R., Johnson, K.R., Naggert, J.K., Nishina, P.M. Nat. Genet. (2002) [Pubmed]
  4. Analysis of microtubule-associated protein 1a gene in hereditary spastic paraplegia. Rainier, S., Jones, S.M., Esposito, C., Guice, E., Otterud, B., Leppert, M., Fink, J.K. Neurology (1998) [Pubmed]
  5. Widespread cellular distribution of MAP-1A (microtubule-associated protein 1A) in the mitotic spindle and on interphase microtubules. Bloom, G.S., Luca, F.C., Vallee, R.B. J. Cell Biol. (1984) [Pubmed]
  6. Distinct structural domains within C19ORF5 support association with stabilized microtubules and mitochondrial aggregation and genome destruction. Liu, L., Vo, A., Liu, G., McKeehan, W.L. Cancer Res. (2005) [Pubmed]
  7. Role for RFX transcription factors in non-neuronal cell-specific inactivation of the microtubule-associated protein MAP1A promoter. Nakayama, A., Murakami, H., Maeyama, N., Yamashiro, N., Sakakibara, A., Mori, N., Takahashi, M. J. Biol. Chem. (2003) [Pubmed]
  8. Identification of a novel microtubule-binding domain in microtubule-associated protein 1A (MAP1A). Cravchik, A., Reddy, D., Matus, A. J. Cell. Sci. (1994) [Pubmed]
  9. Brain-specific expression of human microtubule-associated protein 1A (MAP1A) gene and its assignment to human chromosome 15. Fukuyama, R., Rapoport, S.I. J. Neurosci. Res. (1995) [Pubmed]
  10. The mouse and rat MAP1B genes: genomic organization and alternative transcription. Kutschera, W., Zauner, W., Wiche, G., Propst, F. Genomics (1998) [Pubmed]
  11. The MAP1 family of microtubule-associated proteins. Halpain, S., Dehmelt, L. Genome Biol. (2006) [Pubmed]
  12. Activity-driven dendritic remodeling requires microtubule-associated protein 1A. Szebenyi, G., Bollati, F., Bisbal, M., Sheridan, S., Faas, L., Wray, R., Haferkamp, S., Nguyen, S., Caceres, A., Brady, S.T. Curr. Biol. (2005) [Pubmed]
  13. Gene localization and developmental expression of light chain 3: a common subunit of microtubule-associated protein 1A(MAP1A) and MAP1B. Mann, S.S., Hammarback, J.A. J. Neurosci. Res. (1996) [Pubmed]
  14. Accumulation of microtubule-associated proteins in the hippocampal neurons of seizure-sensitive gerbils. An, S.J., See, M.O., Kim, H.S., Park, S.K., Hwang, I.K., Won, M.H., Kang, T.C. Mol. Cells (2003) [Pubmed]
  15. Evidence that estramustine binds MAP-1A to inhibit type IV collagenase secretion. Stearns, M.E., Wang, M., Sousa, O. J. Cell. Sci. (1991) [Pubmed]
  16. A combined analysis of regional energy metabolism and immunohistochemical ischemic damage in the gerbil brain. Ueda, H., Tagawa, K., Furuya, E., Matsumoto, M., Yanagihara, T. J. Neurochem. (1999) [Pubmed]
  17. Exchange protein directly activated by cAMP (EPAC) interacts with the light chain (LC) 2 of MAP1A. Magiera, M.M., Gupta, M., Rundell, C.J., Satish, N., Ernens, I., Yarwood, S.J. Biochem. J. (2004) [Pubmed]
  18. The guanylate kinase domain of the MAGUK PSD-95 binds dynamically to a conserved motif in MAP1a. Reese, M.L., Dakoji, S., Bredt, D.S., Dötsch, V. Nat. Struct. Mol. Biol. (2007) [Pubmed]
  19. Cloning of human microtubule-associated protein 1B and the identification of a related gene on chromosome 15. Lien, L.L., Feener, C.A., Fischbach, N., Kunkel, L.M. Genomics (1994) [Pubmed]
  20. Identification and characterization of human VCY2-interacting protein: VCY2IP-1, a microtubule-associated protein-like protein. Wong, E.Y., Tse, J.Y., Yao, K.M., Lui, V.C., Tam, P.C., Yeung, W.S. Biol. Reprod. (2004) [Pubmed]
  21. Immunoelectron microscopic study of tubulin and microtubule-associated proteins after transient cerebral ischemia in gerbils. Tomimoto, H., Yanagihara, T. Acta Neuropathol. (1992) [Pubmed]
  22. Regulation of microtubule-associated protein 1B (MAP1B) subunit composition. Mei, X., Sweatt, A.J., Hammarback, J.A. J. Neurosci. Res. (2000) [Pubmed]
  23. Microtubule associated protein MAP1A is an actin-binding and crosslinking protein. Pedrotti, B., Colombo, R., Islam, K. Cell Motil. Cytoskeleton (1994) [Pubmed]
 
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