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Gene Review

Map1a  -  microtubule-associated protein 1A

Rattus norvegicus

Synonyms: MAP-1A, Microtubule-associated protein 1A, Mtap1a
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Disease relevance of Mtap1a


High impact information on Mtap1a

  • There was no particular MT which bound either MAP1A or MAP2 alone [4].
  • To learn which of the MAPs were present in the microtubule bundles in the axon, sections of axons from IDPN-treated rats were examined by immunofluorescence microscopy using antibodies to MAP 1A, MAP 1B, MAP 2, and tubulin [5].
  • We believe that MAP 1A and MAP 1B are major components of the microtubule-associated fibrillar matrix in the axon [5].
  • To determine the distribution of MAP 1A in nervous system tissues and cells, we examined tissue sections from rat brain and spinal cord, as well as primary cultures of newborn rat brain by immunofluorescence microscopy [6].
  • These results indicate that in contrast to MAP 2, which is specifically enriched in dendrites and perikarya of neurons, MAP 1A is widely distributed in the nervous system [6].

Biological context of Mtap1a


Anatomical context of Mtap1a


Associations of Mtap1a with chemical compounds


Other interactions of Mtap1a


Analytical, diagnostic and therapeutic context of Mtap1a


  1. Regenerating sciatic nerve axons contain the adult rather than the embryonic pattern of microtubule associated proteins. Fawcett, J.W., Mathews, G., Housden, E., Goedert, M., Matus, A. Neuroscience (1994) [Pubmed]
  2. Microtubule-associated protein 1A (MAP 1A) is a ganglion cell marker in adult rat retina. McKerracher, L., Vallee, R.B., Aguayo, A.J. Vis. Neurosci. (1989) [Pubmed]
  3. In vivo growth suppression of rat C6 glioma transplanted in rat brain using antisense oligonucleotide for microtubule-associated protein 1A messenger ribonucleic acid. Matsuno, A., Katayama, H., Murakami, M., Nagashima, T. British journal of neurosurgery. (2004) [Pubmed]
  4. Colocalization of microtubule-associated protein 1A and microtubule-associated protein 2 on neuronal microtubules in situ revealed with double-label immunoelectron microscopy. Shiomura, Y., Hirokawa, N. J. Cell Biol. (1987) [Pubmed]
  5. Cytoskeletal architecture and immunocytochemical localization of microtubule-associated proteins in regions of axons associated with rapid axonal transport: the beta,beta'-iminodipropionitrile-intoxicated axon as a model system. Hirokawa, N., Bloom, G.S., Vallee, R.B. J. Cell Biol. (1985) [Pubmed]
  6. Widespread distribution of the major polypeptide component of MAP 1 (microtubule-associated protein 1) in the nervous system. Bloom, G.S., Schoenfeld, T.A., Vallee, R.B. J. Cell Biol. (1984) [Pubmed]
  7. Microtubule associated protein (MAP1A) mRNA was up-regulated by hypergravity in the rat inner ear. Takumi, Y., Iijima, N., Suzuki, N., Oguchi, T., Ando, N., Hashimoto, M., Hara, H., Yamashita, H., Usami, S. Brain Res. Mol. Brain Res. (2002) [Pubmed]
  8. Phosphorylation of microtubule proteins in rat brain at different developmental stages: comparison with that found in neuronal cultures. Díaz-Nido, J., Serrano, L., Hernández, M.A., Avila, J. J. Neurochem. (1990) [Pubmed]
  9. The molecular structure of microtubule-associated protein 1A (MAP1A) in vivo and in vitro. An immunoelectron microscopy and quick-freeze, deep-etch study. Shiomura, Y., Hirokawa, N. J. Neurosci. (1987) [Pubmed]
  10. Direct interaction between BKCa potassium channel and microtubule-associated protein 1A. Park, S.M., Liu, G., Kubal, A., Fury, M., Cao, L., Marx, S.O. FEBS Lett. (2004) [Pubmed]
  11. Identification of a novel microtubule-binding domain in microtubule-associated protein 1A (MAP1A). Cravchik, A., Reddy, D., Matus, A. J. Cell. Sci. (1994) [Pubmed]
  12. Microtubule-associated protein 1a is involved in the early development of the rat spinal cord. Oudega, M., Touri, F., Deenen, M.G., Riederer, B.M., Marani, E. Neurosci. Lett. (1998) [Pubmed]
  13. Estrogen-enhanced neurite growth: evidence for a selective induction of Tau and stable microtubules. Ferreira, A., Caceres, A. J. Neurosci. (1991) [Pubmed]
  14. Microtubule-associated proteins, MAP 1A and MAP 1B, interact with F-actin in vitro. Fujii, T., Watanabe, M., Ogoma, Y., Kondo, Y., Arai, T. J. Biochem. (1993) [Pubmed]
  15. Neuronal plasticity after spinal cord injury: identification of a gene cluster driving neurite outgrowth. Di Giovanni, S., Faden, A.I., Yakovlev, A., Duke-Cohan, J.S., Finn, T., Thouin, M., Knoblach, S., De Biase, A., Bregman, B.S., Hoffman, E.P. FASEB J. (2005) [Pubmed]
  16. Topical application of fibrin adhesive in the rat brain: effects on different cellular elements of the wound. Ghulam Muhammad, A.K., Yoshimine, T., Maruno, M., Takemoto, O., Hayakawa, T. Neurol. Res. (1997) [Pubmed]
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