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Gene Review

TSPAN4  -  tetraspanin 4

Homo sapiens

Synonyms: NAG-2, NAG2, Novel antigen 2, TETRASPAN, TM4SF7, ...
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Disease relevance of TSPAN4


High impact information on TSPAN4


Biological context of TSPAN4


Anatomical context of TSPAN4


Associations of TSPAN4 with chemical compounds

  • A tetraspan membrane glycoprotein produced in the human intestinal epithelium and liver that can regulate cell density-dependent proliferation [16].
  • During the process of characterizing one of these novel genes, we have identified a cDNA clone, a homolog of human/mouse transmembrane-4-superfamily (also known as tetraspan) protein, CD151, the expression of which was significantly decreased in rat frontal cortex following chronic (five weeks) lithium treatment [17].
  • The crystalline complex of turkey-egg lysozyme (TEL) with di-N-acetylchitobiose (NAG2) was prepared by a soaking method and the structure was determined by X-ray analysis at 1.55 A resolution [18].

Co-localisations of TSPAN4


Regulatory relationships of TSPAN4


Other interactions of TSPAN4

  • To further characterize the tetraspan complexes we have raised and selected monoclonal antibodies (mAb) for their ability to immunoprecipitate a molecule associated with CD9 [20].
  • The alpha(3)beta(1)-CD151 association site was then mapped using chimeric alpha(6)/alpha(3) integrins and CD151/NAG2 TM4SF proteins [21].
  • T cell-derived microvesicles also contain the tetraspan protein CD63, suggesting that they originate from endocytic compartments [22].
  • An mAb raised to highly purified, immunoisolated MIICs from human B lymphoblastoid cells recognized CD82, a member of the tetraspan family of integral membrane proteins [23].
  • Gas3/PMP22 is a tetraspan membrane protein highly expressed in myelinating Schwann cells [24].

Analytical, diagnostic and therapeutic context of TSPAN4


  1. Antibodies to CD9, a tetraspan transmembrane protein, inhibit canine distemper virus-induced cell-cell fusion but not virus-cell fusion. Schmid, E., Zurbriggen, A., Gassen, U., Rima, B., ter Meulen, V., Schneider-Schaulies, J. J. Virol. (2000) [Pubmed]
  2. Potential role for CD63 in CCR5-mediated human immunodeficiency virus type 1 infection of macrophages. von Lindern, J.J., Rojo, D., Grovit-Ferbas, K., Yeramian, C., Deng, C., Herbein, G., Ferguson, M.R., Pappas, T.C., Decker, J.M., Singh, A., Collman, R.G., O'Brien, W.A. J. Virol. (2003) [Pubmed]
  3. Enhanced CD9 expression in the mouse and human brains infected with transmissible spongiform encephalopathies. Doh-ura, K., Mekada, E., Ogomori, K., Iwaki, T. J. Neuropathol. Exp. Neurol. (2000) [Pubmed]
  4. Pattern of expression of tetraspanin antigen genes in Burkitt lymphoma cell lines. Ferrer, M., Yunta, M., Lazo, P.A. Clin. Exp. Immunol. (1998) [Pubmed]
  5. Tetraspan microdomains distinct from lipid rafts enrich select peptide-MHC class II complexes. Kropshofer, H., Spindeldreher, S., Röhn, T.A., Platania, N., Grygar, C., Daniel, N., Wölpl, A., Langen, H., Horejsi, V., Vogt, A.B. Nat. Immunol. (2002) [Pubmed]
  6. The tetraspan molecule CD151, a novel constituent of hemidesmosomes, associates with the integrin alpha6beta4 and may regulate the spatial organization of hemidesmosomes. Sterk, L.M., Geuijen, C.A., Oomen, L.C., Calafat, J., Janssen, H., Sonnenberg, A. J. Cell Biol. (2000) [Pubmed]
  7. NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins. Tachibana, I., Bodorova, J., Berditchevski, F., Zutter, M.M., Hemler, M.E. J. Biol. Chem. (1997) [Pubmed]
  8. CD9, CD63, CD81, and CD82 are components of a surface tetraspan network connected to HLA-DR and VLA integrins. Rubinstein, E., Le Naour, F., Lagaudrière-Gesbert, C., Billard, M., Conjeaud, H., Boucheix, C. Eur. J. Immunol. (1996) [Pubmed]
  9. Function of tetraspan proteins in the myelin sheath. Bronstein, J.M. Curr. Opin. Neurobiol. (2000) [Pubmed]
  10. Molecular cloning of cDNA encoding a novel platelet-endothelial cell tetra-span antigen, PETA-3. Fitter, S., Tetaz, T.J., Berndt, M.C., Ashman, L.K. Blood (1995) [Pubmed]
  11. A novel five-transmembrane hematopoietic stem cell antigen: isolation, characterization, and molecular cloning. Miraglia, S., Godfrey, W., Yin, A.H., Atkins, K., Warnke, R., Holden, J.T., Bray, R.A., Waller, E.K., Buck, D.W. Blood (1997) [Pubmed]
  12. Immunohistological analysis of normal and osteoarthritic human synovial tissue. Korkusuz, P., Dagdeviren, A., Eksioglu, F., Ors, U. Bulletin (Hospital for Joint Diseases (New York, N.Y.)) (2005) [Pubmed]
  13. CDw78 Defines MHC Class II-Peptide Complexes That Require Ii Chain-Dependent Lysosomal Trafficking, Not Localization to a Specific Tetraspanin Membrane Microdomain. Poloso, N.J., Denzin, L.K., Roche, P.A. J. Immunol. (2006) [Pubmed]
  14. Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes. Escola, J.M., Kleijmeer, M.J., Stoorvogel, W., Griffith, J.M., Yoshie, O., Geuze, H.J. J. Biol. Chem. (1998) [Pubmed]
  15. CD9, a tetraspan transmembrane protein, renders cells susceptible to canine distemper virus. Löffler, S., Lottspeich, F., Lanza, F., Azorsa, D.O., ter Meulen, V., Schneider-Schaulies, J. J. Virol. (1997) [Pubmed]
  16. A tetraspan membrane glycoprotein produced in the human intestinal epithelium and liver that can regulate cell density-dependent proliferation. Wice, B.M., Gordon, J.I. J. Biol. Chem. (1995) [Pubmed]
  17. Tetraspan protein CD151: a common target of mood stabilizing drugs? Hua, L.V., Green, M., Wong, A., Warsh, J.J., Li, P.P. Neuropsychopharmacology (2001) [Pubmed]
  18. X-ray structure of turkey egg lysozyme complex with di-N-acetyl-chitobiose. Recognition and binding of alpha-anomeric form. Harata, K., Muraki, M. Acta Crystallogr. D Biol. Crystallogr. (1995) [Pubmed]
  19. Expression of epithelial membrane protein-2 is associated with endometrial adenocarcinoma of unfavorable outcome. Wadehra, M., Natarajan, S., Seligson, D.B., Williams, C.J., Hummer, A.J., Hedvat, C., Braun, J., Soslow, R.A. Cancer (2006) [Pubmed]
  20. CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans. Lozahic, S., Christiansen, D., Manié, S., Gerlier, D., Billard, M., Boucheix, C., Rubinstein, E. Eur. J. Immunol. (2000) [Pubmed]
  21. Direct extracellular contact between integrin alpha(3)beta(1) and TM4SF protein CD151. Yauch, R.L., Kazarov, A.R., Desai, B., Lee, R.T., Hemler, M.E. J. Biol. Chem. (2000) [Pubmed]
  22. TCR activation of human T cells induces the production of exosomes bearing the TCR/CD3/zeta complex. Blanchard, N., Lankar, D., Faure, F., Regnault, A., Dumont, C., Raposo, G., Hivroz, C. J. Immunol. (2002) [Pubmed]
  23. The tetraspan protein CD82 is a resident of MHC class II compartments where it associates with HLA-DR, -DM, and -DO molecules. Hammond, C., Denzin, L.K., Pan, M., Griffith, J.M., Geuze, H.J., Cresswell, P. J. Immunol. (1998) [Pubmed]
  24. Exposure at the cell surface is required for gas3/PMP22 To regulate both cell death and cell spreading: implication for the Charcot-Marie-Tooth type 1A and Dejerine-Sottas diseases. Brancolini, C., Edomi, P., Marzinotto, S., Schneider, C. Mol. Biol. Cell (2000) [Pubmed]
  25. Activated platelets release two types of membrane vesicles: microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and alpha-granules. Heijnen, H.F., Schiel, A.E., Fijnheer, R., Geuze, H.J., Sixma, J.J. Blood (1999) [Pubmed]
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