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Ptk6  -  PTK6 protein tyrosine kinase 6

Mus musculus

Synonyms: BRK, Protein-tyrosine kinase 6, SRC-related intestinal kinase, Sik, Tksk, ...
 
 
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Disease relevance of Ptk6

 

High impact information on Ptk6

  • A role for the epithelial-cell-specific tyrosine kinase Sik during keratinocyte differentiation [1].
  • These data suggest that Sik is not responsible for phosphorylation of GAP-A.p65 [1].
  • Overexpression of Sik in EMK cells results in increased expression of filaggrin during differentiation, supporting a role for Sik in differentiation [1].
  • STAP-2 is a murine homologue of a recently identified adaptor molecule, BKS, a substrate of BRK tyrosine kinase [4].
  • Structurally, Sik-SP belongs to the nucleolar Nop5/Sik family whose members play central roles in ribosome biogenesis; however, the function of Sik-SP has not been examined [2].
 

Chemical compound and disease context of Ptk6

  • Protein tyrosine kinase 6 (PTK6) (also called Brk or Sik) is an intracellular tyrosine kinase that is expressed in breast cancer and normal epithelial linings [5].
 

Biological context of Ptk6

 

Anatomical context of Ptk6

 

Associations of Ptk6 with chemical compounds

 

Analytical, diagnostic and therapeutic context of Ptk6

  • When the PCR products were sequenced, 13 distinct clones were found, of which one is novel to date and has provisionally been named tks (for tyrosine kinase identified from skin) [8].

References

  1. A role for the epithelial-cell-specific tyrosine kinase Sik during keratinocyte differentiation. Vasioukhin, V., Tyner, A.L. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  2. Increased expression of a nucleolar Nop5/Sik family member in metastatic melanoma cells: evidence for its role in nucleolar sizing and function. Nakamoto, K., Ito, A., Watabe, K., Koma, Y., Asada, H., Yoshikawa, K., Shinomura, Y., Matsuzawa, Y., Nojima, H., Kitamura, Y. Am. J. Pathol. (2001) [Pubmed]
  3. Cytogenetic analysis of spontaneous and 2-cyanoethylene oxide-induced tk-/- mutants in TK6 human lymphoblastoid cultures. Kodama, Y., Boreiko, C.J., Skopek, T.R., Recio, L. Environ. Mol. Mutagen. (1989) [Pubmed]
  4. STAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motif. Minoguchi, M., Minoguchi, S., Aki, D., Joo, A., Yamamoto, T., Yumioka, T., Matsuda, T., Yoshimura, A. J. Biol. Chem. (2003) [Pubmed]
  5. Protein tyrosine kinase 6 negatively regulates growth and promotes enterocyte differentiation in the small intestine. Haegebarth, A., Bie, W., Yang, R., Crawford, S.E., Vasioukhin, V., Fuchs, E., Tyner, A.L. Mol. Cell. Biol. (2006) [Pubmed]
  6. Tyrosine kinase gene expression in the mouse small intestine. Siyanova, E.Y., Serfas, M.S., Mazo, I.A., Tyner, A.L. Oncogene (1994) [Pubmed]
  7. BRK/Sik expression in the gastrointestinal tract and in colon tumors. Llor, X., Serfas, M.S., Bie, W., Vasioukhin, V., Polonskaia, M., Derry, J., Abbott, C.M., Tyner, A.L. Clin. Cancer Res. (1999) [Pubmed]
  8. Identification of a novel cDNA clone encoding protein tyrosine kinase in murine skin. Kawachi, Y., Nakauchi, H., Otsuka, F. J. Dermatol. (1994) [Pubmed]
  9. Altered localization and activity of the intracellular tyrosine kinase BRK/Sik in prostate tumor cells. Derry, J.J., Prins, G.S., Ray, V., Tyner, A.L. Oncogene (2003) [Pubmed]
 
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