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Gene Review

Lamc1  -  laminin, gamma 1

Mus musculus

Synonyms: Lamb-2, Lamb2, Lamc-1, Laminin B2 chain, Laminin subunit gamma-1, ...
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High impact information on Lamc1


Biological context of Lamc1


Anatomical context of Lamc1

  • Using a retinal cDNA from the rat and somatic cell hybrids, we have mapped the gene corresponding to this protein to mouse Chromosome 1 and, by analyzing the progeny of an intersubspecific backcross, have positioned it near Lamb2 (the beta 2 chain of laminin) [5].
  • In order to define the individual roles and interactions between these factors in endodermal differentiation, we have used embryoid bodies derived from Lamc1(-/-) embryonic stem cells that lack basement membranes [9].
  • To determine whether laminin B2 chain mRNA levels change in response to cytokines, total mRNA from rat glomerular epithelial cells (GEC) grown in culture was analyzed by Northern blots [8].

Physical interactions of Lamc1

  • The immunoglobulin kappa B and the laminin B2 chain kappa B-like motifs competed for the same DNA binding activity in nuclear extracts from IL-1 beta-treated GEC [8].

Regulatory relationships of Lamc1


Other interactions of Lamc1


  1. Production of laminin B2 chain protein and messenger RNA by a murine neutrophil precursor cell line, 32Dc13. Tweardy, D.J., Sasaki, M., Cardamone, J.J., McCoy, J.P., Bonidie, M.J., Signorella, A.P. Blood (1990) [Pubmed]
  2. Compositional and structural requirements for laminin and basement membranes during mouse embryo implantation and gastrulation. Miner, J.H., Li, C., Mudd, J.L., Go, G., Sutherland, A.E. Development (2004) [Pubmed]
  3. Specific ablation of the nidogen-binding site in the laminin gamma1 chain interferes with kidney and lung development. Willem, M., Miosge, N., Halfter, W., Smyth, N., Jannetti, I., Burghart, E., Timpl, R., Mayer, U. Development (2002) [Pubmed]
  4. The laminin B2 chain promoter contains unique repeat sequences and is active in transient transfection. Ogawa, K., Burbelo, P.D., Sasaki, M., Yamada, Y. J. Biol. Chem. (1988) [Pubmed]
  5. The gene for retinal rod 33-kDa protein is on mouse chromosome 1, near Lamb2. Danciger, M., Kozak, C.A., Abe, T., Shinohara, T., Farber, D.B. Cytogenet. Cell Genet. (1991) [Pubmed]
  6. Role of mesenchymal nidogen for epithelial morphogenesis in vitro. Ekblom, P., Ekblom, M., Fecker, L., Klein, G., Zhang, H.Y., Kadoya, Y., Chu, M.L., Mayer, U., Timpl, R. Development (1994) [Pubmed]
  7. Primary structure of the mouse laminin B2 chain and comparison with laminin B1. Durkin, M.E., Bartos, B.B., Liu, S.H., Phillips, S.L., Chung, A.E. Biochemistry (1988) [Pubmed]
  8. IL-1 beta increases laminin B2 chain mRNA levels and activates NF-kappa B in rat glomerular epithelial cells. Richardson, C.A., Gordon, K.L., Couser, W.G., Bomsztyk, K. Am. J. Physiol. (1995) [Pubmed]
  9. Regulation of the differentiation and behaviour of extra-embryonic endodermal cells by basement membranes. Murray, P., Edgar, D. J. Cell. Sci. (2001) [Pubmed]
  10. Gene mapping of mouse laminin A and B2 subunits using mouse-Chinese hamster somatic cell hybrids. Kaye, N.W., Chung, A.E., Lalley, P.A., Durkin, M.E., Phillips, S.L., Church, R.L. Somat. Cell Mol. Genet. (1990) [Pubmed]
  11. Rapid and efficient construction of yeast artificial chromosome contigs in the mouse genome with interspersed repetitive sequence PCR (IRS-PCR): generation of a 5-cM, > 5 megabase contig on mouse chromosome 1. Hunter, K.W., Ontiveros, S.D., Watson, M.L., Stanton, V.P., Gutierrez, P., Bhat, D., Rochelle, J., Graw, S., Ton, C., Schalling, M. Mamm. Genome (1994) [Pubmed]
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