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Gene Review

LanB2  -  Laminin B2

Drosophila melanogaster

Synonyms: CG3322, CT11145, DROLAMB2A, Dmel\CG3322, LAMB2A, ...
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Disease relevance of LanB2


High impact information on LanB2


Biological context of LanB2


Anatomical context of LanB2

  • Failure to down-regulate Dystroglycan disrupts apicobasal polarity in the PFC, which includes mislocalization of the extracellular matrix component Laminin [9].
  • Laminin, a major component of basement membranes, is a large glycoprotein consisting of three disulfide-bonded subunits, A, B1, and B2 [10].
  • Finally, during midgut formation, the endoderm fails to undergo the initial columnar polarization in the absence of functional laminin [6].
  • Using several cell lines, the laminin alpha2 chain peptides showed cell attachment and/or spreading activities with cell type specificities [11].
  • Cells from Drosophila embryos dissociated at the cellular blastoderm stage were grown in culture and some specific, differentiated cells synthesized laminin after several hours of culture as shown by immunofluorescence [12].

Associations of LanB2 with chemical compounds


Physical interactions of LanB2

  • The amino acid composition and lectin-binding properties of Drosophila laminin are given [12].

Other interactions of LanB2

  • Primary structure of the Drosophila laminin B2 chain and comparison with human, mouse, and Drosophila laminin B1 and B2 chains [10].
  • In particular, the function of laminin during mesoderm development and morphogenesis was dissected by analyzing embryos deficient in laminin A chain alone or in both laminin A and B2 chains [6].
  • Cloning and biological function of laminin in Hydra vulgaris [14].
  • A family of laminin-related proteins controlling ectodermal differentiation in Drosophila [15].
  • These results suggest that biologically active regions in the G domain are conserved in the laminin alpha1 and alpha2 chains, and that these regions in laminin play an important role in cell surface receptor interactions [11].

Analytical, diagnostic and therapeutic context of LanB2


  1. Sp1-mediated transactivation of LamC1 promoter and coordinated expression of laminin-gamma1 and Sp1 in human hepatocellular carcinomas. Liétard, J., Musso, O., Théret, N., L'Helgoualc'h, A., Campion, J.P., Yamada, Y., Clément, B. Am. J. Pathol. (1997) [Pubmed]
  2. Interaction of Bombyx mori nucleopolyhedrovirus BRO-A and host cell protein laminin. Kang, W.K., Imai, N., Suzuki, M., Iwanaga, M., Matsumoto, S., Zemskov, E.A. Arch. Virol. (2003) [Pubmed]
  3. A role for integrin in the formation of sarcomeric cytoarchitecture. Volk, T., Fessler, L.I., Fessler, J.H. Cell (1990) [Pubmed]
  4. Laminin in the male germ cells of Drosophila. Wang, F., Hanske, M., Miedema, K., Klein, G., Ekblom, P., Hennig, W. J. Cell Biol. (1992) [Pubmed]
  5. Drosophila laminin: sequence of B2 subunit and expression of all three subunits during embryogenesis. Montell, D.J., Goodman, C.S. J. Cell Biol. (1989) [Pubmed]
  6. Laminin is required for heart, somatic muscles, and gut development in the Drosophila embryo. Yarnitzky, T., Volk, T. Dev. Biol. (1995) [Pubmed]
  7. Adhesion-dependent tyrosine phosphorylation of enabled in Drosophila neuronal cell line. Takagi, Y., Ui-Tei, K., Hirohashi, S. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  8. Drosophila laminin binds to mammalian nidogen and to heparan sulfate proteoglycan. Mayer, U., Mann, K., Fessler, L.I., Fessler, J.H., Timpl, R. Eur. J. Biochem. (1997) [Pubmed]
  9. Dystroglycan down-regulation links EGF receptor signaling and anterior-posterior polarity formation in the Drosophila oocyte. Poulton, J.S., Deng, W.M. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  10. Primary structure of the Drosophila laminin B2 chain and comparison with human, mouse, and Drosophila laminin B1 and B2 chains. Chi, H.C., Hui, C.F. J. Biol. Chem. (1989) [Pubmed]
  11. Active peptides from the carboxyl-terminal globular domain of laminin alpha2 and Drosophila alpha chains. Nomizu, M., Song, S.Y., Kuratomi, Y., Tanaka, M., Kim, W.H., Kleinman, H.K., Yamada, Y. FEBS Lett. (1996) [Pubmed]
  12. Drosophila laminin: characterization and localization. Fessler, L.I., Campbell, A.G., Duncan, K.G., Fessler, J.H. J. Cell Biol. (1987) [Pubmed]
  13. The distribution of PS integrins, laminin A and F-actin during key stages in Drosophila wing development. Fristrom, D., Wilcox, M., Fristrom, J. Development (1993) [Pubmed]
  14. Cloning and biological function of laminin in Hydra vulgaris. Sarras, M.P., Yan, L., Grens, A., Zhang, X., Agbas, A., Huff, J.K., St John, P.L., Abrahamson, D.R. Dev. Biol. (1994) [Pubmed]
  15. A family of laminin-related proteins controlling ectodermal differentiation in Drosophila. Patthy, L. FEBS Lett. (1992) [Pubmed]
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