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Gene Review

ACSL6  -  acyl-CoA synthetase long-chain family...

Homo sapiens

Synonyms: ACS2, FACL6, KIAA0837, LACS 6, LACS2, ...
 
 
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Disease relevance of ACSL6

 

High impact information on ACSL6

  • We typed 289 SNPs in the critical interval of 8 million basepairs and found a 758 kb interval coding for the SPEC2/PDZ-GEF2/ACSL6 genes to be associated with the disease [4].
  • From these data, we concluded that haplotypes underlying the SPEC2/PDZ-GEF2/ACSL6 region are associated with schizophrenia [4].
  • Two cDNA clones encoding ACC synthase, Ps-ACS1 and Ps-ACS2, were isolated from a cDNA library prepared from the apical hooks of etiolated pea seedlings that had been treated with 100 microns IAA for 4 h [5].
  • ACSL3 and the two variants of ACSL6 were more resistant than ACSL4 to heat inactivation [6].
  • These data further document important differences in the closely related ACSL isoforms and show that amino acid changes near the consensus nucleotide binding site alter function in the two splice variants of ACSL6 [6].
 

Biological context of ACSL6

 

Anatomical context of ACSL6

 

Associations of ACSL6 with chemical compounds

 

Other interactions of ACSL6

  • Reciprocal ACS2/ETV6 transcripts were identified in two of the cases [2].

References

  1. t(5;12)(q23-31;p13) with ETV6-ACSL6 gene fusion in polycythemia vera. Murati, A., Adélaïde, J., Gelsi-Boyer, V., Etienne, A., Rémy, V., Fezoui, H., Sainty, D., Xerri, L., Vey, N., Olschwang, S., Birnbaum, D., Chaffanet, M., Mozziconacci, M.J. Leukemia (2006) [Pubmed]
  2. Fusion of TEL/ETV6 to a novel ACS2 in myelodysplastic syndrome and acute myelogenous leukemia with t(5;12)(q31;p13). Yagasaki, F., Jinnai, I., Yoshida, S., Yokoyama, Y., Matsuda, A., Kusumoto, S., Kobayashi, H., Terasaki, H., Ohyashiki, K., Asou, N., Murohashi, I., Bessho, M., Hirashima, K. Genes Chromosomes Cancer (1999) [Pubmed]
  3. American Elm (Ulmus americana). Newhouse, A.E., Schrodt, F., Maynard, C.A., Powell, W.A. Methods Mol. Biol. (2006) [Pubmed]
  4. Haplotypes spanning SPEC2, PDZ-GEF2 and ACSL6 genes are associated with schizophrenia. Chen, X., Wang, X., Hossain, S., O'neill, F.A., Walsh, D., Pless, L., Chowdari, K.V., Nimgaonkar, V.L., Schwab, S.G., Wildenauer, D.B., Sullivan, P.F., van den Oord, E., Kendler, K.S. Hum. Mol. Genet. (2006) [Pubmed]
  5. A gene encoding 1-aminocyclopropane-1-carboxylate (ACC) synthase produces two transcripts: elucidation of a conserved response. Peck, S.C., Kende, H. Plant J. (1998) [Pubmed]
  6. Characterization of recombinant long-chain rat acyl-CoA synthetase isoforms 3 and 6: identification of a novel variant of isoform 6. Van Horn, C.G., Caviglia, J.M., Li, L.O., Wang, S., Granger, D.A., Coleman, R.A. Biochemistry (2005) [Pubmed]
  7. Specificities of functionally expressed chalcone and acridone synthases from Ruta graveolens. Springob, K., Lukacin, R., Ernwein, C., Gröning, I., Matern, U. Eur. J. Biochem. (2000) [Pubmed]
  8. Multiple erythroid isoforms of human long-chain acyl-CoA synthetases are produced by switch of the fatty acid gate domains. Soupene, E., Kuypers, F.A. BMC Mol. Biol. (2006) [Pubmed]
  9. Identification and molecular characterization of acyl-CoA synthetase in human erythrocytes and erythroid precursors. Malhotra, K.T., Malhotra, K., Lubin, B.H., Kuypers, F.A. Biochem. J. (1999) [Pubmed]
  10. Differential regulation of genes encoding 1-aminocyclopropane-1-carboxylate (ACC) synthase in etiolated pea seedlings: effects of indole-3-acetic acid, wounding, and ethylene. Peck, S.C., Kende, H. Plant Mol. Biol. (1998) [Pubmed]
 
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