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Gene Review

ACSL3  -  acyl-CoA synthetase long-chain family...

Homo sapiens

Synonyms: ACS3, FACL3, LACS 3, LACS3, Long-chain acyl-CoA synthetase 3, ...
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Disease relevance of ACSL3


High impact information on ACSL3


Chemical compound and disease context of ACSL3

  • In our previous studies, we found that FAS and FACL3 genes were vitamin D3-regulated and involved in the antiproliferative effect of 1alpha,25(OH)2D3 in the human prostate cancer LNCaP cells [7].

Biological context of ACSL3


Anatomical context of ACSL3


Associations of ACSL3 with chemical compounds


Regulatory relationships of ACSL3


Other interactions of ACSL3

  • Because ACSL3 and ACSL6 are the predominant ACSL isoforms in brain, we cloned and characterized these isoforms from rat brain and identified a novel ACSL6 clone (ACSL6_v2) [2].
  • This suggests that the downregulation of FAS expression by vitamin D3 is mediated by vitamin D3 upregulation of FACL3 expression [7].
  • Three converted SCAR markers (ACS-3, -7, and -9) are inseparable from the Vf gene; whereas one (ACS-6) is located left of, and the remaining seven (ACS-1, -2, -4, -5, -8, -10, and -11) are located right of the Vf gene at genetic distances of 0.4 and 0.2 cM, respectively [10].

Analytical, diagnostic and therapeutic context of ACSL3


  1. The role of long-chain fatty-acid-CoA ligase 3 in vitamin D3 and androgen control of prostate cancer LNCaP cell growth. Qiao, S., Tuohimaa, P. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  2. Characterization of recombinant long-chain rat acyl-CoA synthetase isoforms 3 and 6: identification of a novel variant of isoform 6. Van Horn, C.G., Caviglia, J.M., Li, L.O., Wang, S., Granger, D.A., Coleman, R.A. Biochemistry (2005) [Pubmed]
  3. Genomic organization and transcription units of the human acyl-CoA synthetase 3 gene. Minekura, H., Kang, M.J., Inagaki, Y., Suzuki, H., Sato, H., Fujino, T., Yamamoto, T.T. Gene (2001) [Pubmed]
  4. Photodynamic effects of antioxidant substituted porphyrin photosensitizers on gram-positive and -negative bacterial. Ashkenazi, H., Nitzan, Y., Gál, D. Photochem. Photobiol. (2003) [Pubmed]
  5. Molecular characterization and expression of rat acyl-CoA synthetase 3. Fujino, T., Kang, M.J., Suzuki, H., Iijima, H., Yamamoto, T. J. Biol. Chem. (1996) [Pubmed]
  6. Analysis of LE-ACS3, a 1-aminocyclopropane-1-carboxylic acid synthase gene expressed during flooding in the roots of tomato plants. Olson, D.C., Oetiker, J.H., Yang, S.F. J. Biol. Chem. (1995) [Pubmed]
  7. Vitamin D3 inhibits fatty acid synthase expression by stimulating the expression of long-chain fatty-acid-CoA ligase 3 in prostate cancer cells. Qiao, S., Tuohimaa, P. FEBS Lett. (2004) [Pubmed]
  8. Human acyl-coenzyme A synthetase 3 cDNA and localization of its gene (ACS3) to chromosome band 2q34-q35. Minekura, H., Fujino, T., Kang, M.J., Fujita, T., Endo, Y., Yamamoto, T.T. Genomics (1997) [Pubmed]
  9. Identification of major proteins in the lipid droplet-enriched fraction isolated from the human hepatocyte cell line HuH7. Fujimoto, Y., Itabe, H., Sakai, J., Makita, M., Noda, J., Mori, M., Higashi, Y., Kojima, S., Takano, T. Biochim. Biophys. Acta (2004) [Pubmed]
  10. Development of sequence-characterized amplified regions (SCARs) from amplified fragment length polymorphism (AFLP) markers tightly linked to the Vf gene in apple. Xu, M., Huaracha, E., Korban, S.S. Genome (2001) [Pubmed]
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