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Gene Review

Mgll  -  monoglyceride lipase

Mus musculus

Synonyms: AA589436, MAGL, MGL, Magl, Mgl, ...
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Disease relevance of Mgll

  • The mouse MGL cDNA was subcloned into a baculovirus transfer vector in frame with a sequence encoding an N-terminal stretch of six histidine residues [1].

High impact information on Mgll


Biological context of Mgll

  • Characterization of the clones obtained revealed that the mouse gene contains the coding sequence for MGL on seven exons, including a large terminal exon of approximately 2.6 kb containing the stop codon and the complete 3' untranslated region [6].
  • These include: CYP2B9, CYP2B10, monoglyceride lipase, pyruvate dehydrogenase-kinase-4, cell death-inducing DNA-fragmentation factor-alpha, peroxisomal biogenesis factor 11beta, as well as several cell recognition surface proteins including annexin A2, CD24, CD39, lymphocyte antigen 6, and retinoic acid early transcript-gamma, among others [7].
  • Quantitative morphometric analysis following muscle crush injury of 2 Mm musculus strains, MBK and MGL, has indicated that regeneration phenotype is not species-specific and may not be directly related to MyoD1 alleles [8].

Anatomical context of Mgll

  • Furthermore, we show that astrocytes express monoacylglycerol lipase (MGL), the main hydrolyzing enzyme of 2-AG, the pharmacological inhibition of which potentiates the ATP-induced 2-AG production (up to 113-fold of basal 2-AG production at 2.5 min) [9].
  • Differentiation of 3T3-L1 fibroblasts to adipocyte-like cells was accompanied by a 19-fold increase in neutral triglyceride lipase activity, a 12-fold increase in diglyceride lipase activity, a 10-fold increase in monoglyceride lipase activity, and a 280-fold increase in cholesterol esterase activity [2].
  • Immunostaining for MGL was complementary, the axons in the molecular layer were intensively labelled leaving the Purkinje cell dendrites blank [5].
  • With monoolein as substrate, the specific activity and the apparent K(m) were close to those of rat MGL of adipose tissue [1].

Associations of Mgll with chemical compounds

  • Monoglyceride lipase (MGL) functions together with hormone-sensitive lipase to hydrolyze intracellular triglyceride stores of adipocytes and other cells to fatty acids and glycerol [6].
  • Expression, purification, and characterization of histidine-tagged mouse monoglyceride lipase from baculovirus-infected insect cells [1].
  • Altogether, MGL mice showed a more restless behavior, a higher rectal temperature, and much higher brain (+17%) and urine (+200%) noradrenaline levels than the MGH animals [10].

Analytical, diagnostic and therapeutic context of Mgll


  1. Expression, purification, and characterization of histidine-tagged mouse monoglyceride lipase from baculovirus-infected insect cells. Karlsson, M., Tornqvist, H., Holm, C. Protein Expr. Purif. (2000) [Pubmed]
  2. Hormone-sensitive lipase in differentiated 3T3-L1 cells and its activation by cyclic AMP-dependent protein kinase. Kawamura, M., Jensen, D.F., Wancewicz, E.V., Joy, L.L., Khoo, J.C., Steinberg, D. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  3. cDNA cloning, tissue distribution, and identification of the catalytic triad of monoglyceride lipase. Evolutionary relationship to esterases, lysophospholipases, and haloperoxidases. Karlsson, M., Contreras, J.A., Hellman, U., Tornqvist, H., Holm, C. J. Biol. Chem. (1997) [Pubmed]
  4. Depolarization-induced retrograde synaptic inhibition in the mouse cerebellar cortex is mediated by 2-arachidonoylglycerol. Szabo, B., Urbanski, M.J., Bisogno, T., Marzo, V.D., Mendiguren, A., Baer, W.U., Freiman, I. J. Physiol. (Lond.) (2006) [Pubmed]
  5. Segregation of two endocannabinoid-hydrolyzing enzymes into pre- and postsynaptic compartments in the rat hippocampus, cerebellum and amygdala. Gulyas, A.I., Cravatt, B.F., Bracey, M.H., Dinh, T.P., Piomelli, D., Boscia, F., Freund, T.F. Eur. J. Neurosci. (2004) [Pubmed]
  6. Exon-intron organization and chromosomal localization of the mouse monoglyceride lipase gene. Karlsson, M., Reue, K., Xia, Y.R., Lusis, A.J., Langin, D., Tornqvist, H., Holm, C. Gene (2001) [Pubmed]
  7. Identification of novel peroxisome proliferator-activated receptor alpha (PPARalpha) target genes in mouse liver using cDNA microarray analysis. Cherkaoui-Malki, M., Meyer, K., Cao, W.Q., Latruffe, N., Yeldandi, A.V., Rao, M.S., Bradfield, C.A., Reddy, J.K. Gene Expr. (2001) [Pubmed]
  8. Investigation of the influence of the Mm musculus MyoD1 allele on the efficiency of skeletal muscle regeneration. Marlow, S.A., Kay, P.H., McGeachie, J.K., Papadimitriou, J.M. J. Anat. (1997) [Pubmed]
  9. ATP induces a rapid and pronounced increase in 2-arachidonoylglycerol production by astrocytes, a response limited by monoacylglycerol lipase. Walter, L., Dinh, T., Stella, N. J. Neurosci. (2004) [Pubmed]
  10. Mice selected for low and high blood magnesium levels: a new model for stress studies. Henrotte, J.G., Franck, G., Santarromana, M., Francès, H., Mouton, D., Motta, R. Physiol. Behav. (1997) [Pubmed]
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