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Gene Review

Cel  -  carboxyl ester lipase

Mus musculus

Synonyms: 1810036E18Rik, BAL, BSSL, Bile salt-activated lipase, Bile salt-stimulated lipase, ...
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Disease relevance of Cel

  • Carboxyl ester lipase overexpression in rat hepatoma cells and CEL deficiency in mice have no impact on hepatic uptake or metabolism of chylomicron-retinyl ester [1].
  • Liposomes composed of chemically synthesized glyceroglycolipids, such as 1,2-dipalmityl-[beta-cellobiosyl-(1'----3)]- glycerol (Cel-DAG), 1,2-dipalmityl-[beta-lactosyl-(1'----3)]-glycerol, or 1,2-dipalmityl-[beta-maltosyl-(1'----3)]-glycerol, were found to enhance protective immunity against transplantable tumor cells (sarcoma 180) in ICR mice [2].
  • Tissue inflammation, goblet cell hyperplasia, and IL-4, IL-5, and IL-13 levels in BAL fluid were significantly reduced in fB-/- mice compared with C4-/- and WT mice [3].
  • Early dosage, and the combination of early and late dosages, strikingly decreased ragweed-specific serum IgE, tracheal ring reactivity to acetylcholine, and BAL eosinophilia following allergen challenge [4].
  • However, different injury mechanisms were operative since (1) CE, but not CO, toxicity significantly altered cell phospholipid profiles, and (2) 2 mmol/L glycine completely blocked CE- but not CO-mediated cell death [5].

High impact information on Cel


Chemical compound and disease context of Cel


Biological context of Cel


Anatomical context of Cel


Associations of Cel with chemical compounds


Regulatory relationships of Cel


Other interactions of Cel


Analytical, diagnostic and therapeutic context of Cel


  1. Carboxyl ester lipase overexpression in rat hepatoma cells and CEL deficiency in mice have no impact on hepatic uptake or metabolism of chylomicron-retinyl ester. van Bennekum, A.M., Li, L., Piantedosi, R., Shamir, R., Vogel, S., Fisher, E.A., Blaner, W.S., Harrison, E.H. Biochemistry (1999) [Pubmed]
  2. Activation of mouse peritoneal macrophages by synthetic glyceroglycolipid liposomes. Naito, M., Kudo, I., Mukai-Sato, Y., Tsushima, S., Nomura, H., Nojima, S., Inoue, K. Cancer Immunol. Immunother. (1987) [Pubmed]
  3. Factor B of the alternative complement pathway regulates development of airway hyperresponsiveness and inflammation. Taube, C., Thurman, J.M., Takeda, K., Joetham, A., Miyahara, N., Carroll, M.C., Dakhama, A., Giclas, P.C., Holers, V.M., Gelfand, E.W. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  4. Immunomodulatory effects of IL-12 on allergic lung inflammation depend on timing of doses. Sur, S., Lam, J., Bouchard, P., Sigounas, A., Holbert, D., Metzger, W.J. J. Immunol. (1996) [Pubmed]
  5. Plasma membrane cholesterol: a critical determinant of cellular energetics and tubular resistance to attack. Zager, R.A. Kidney Int. (2000) [Pubmed]
  6. Hormone-sensitive lipase in differentiated 3T3-L1 cells and its activation by cyclic AMP-dependent protein kinase. Kawamura, M., Jensen, D.F., Wancewicz, E.V., Joy, L.L., Khoo, J.C., Steinberg, D. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  7. c-mos expression in mouse oocytes is controlled by initiator-related sequences immediately downstream of the transcription initiation site. Pal, S.K., Zinkel, S.S., Kiessling, A.A., Cooper, G.M. Mol. Cell. Biol. (1991) [Pubmed]
  8. Carboxyl ester lipase expression in macrophages increases cholesteryl ester accumulation and promotes atherosclerosis. Kodvawala, A., Ghering, A.B., Davidson, W.S., Hui, D.Y. J. Biol. Chem. (2005) [Pubmed]
  9. Role for innate IFNs in determining respiratory syncytial virus immunopathology. Johnson, T.R., Mertz, S.E., Gitiban, N., Hammond, S., Legallo, R., Durbin, R.K., Durbin, J.E. J. Immunol. (2005) [Pubmed]
  10. Nitrogen dioxide enhances allergic airway inflammation and hyperresponsiveness in the mouse. Poynter, M.E., Persinger, R.L., Irvin, C.G., Butnor, K.J., van Hirtum, H., Blay, W., Heintz, N.H., Robbins, J., Hemenway, D., Taatjes, D.J., Janssen-Heininger, Y. Am. J. Physiol. Lung Cell Mol. Physiol. (2006) [Pubmed]
  11. Interleukin-10 does not mediate inhalational tolerance in a chronic model of ovalbumin-induced allergic airway disease. Kabbur, P.M., Carson, W.F., Guernsey, L., Secor, E.R., Thrall, R.S., Schramm, C.M. Cell. Immunol. (2006) [Pubmed]
  12. Amelioration by BAL (2,3-dimercapto-1-propanol) and DMPS (sodium 2,3-dimercapto-1-propanesulfonic acid) of arsenite developmental toxicity in mice. Domingo, J.L., Bosque, M.A., Llobet, J.M., Corbella, J. Ecotoxicol. Environ. Saf. (1992) [Pubmed]
  13. Studies of the regulation of the mouse carboxyl ester lipase gene in mammary gland. Kannius-Janson, M., Lidberg, U., Hultén, K., Gritli-Linde, A., Bjursell, G., Nilsson, J. Biochem. J. (1998) [Pubmed]
  14. Chromosomal localization of lipolytic enzymes in the mouse: pancreatic lipase, colipase, hormone-sensitive lipase, hepatic lipase, and carboxyl ester lipase. Warden, C.H., Davis, R.C., Yoon, M.Y., Hui, D.Y., Svenson, K., Xia, Y.R., Diep, A., He, K.Y., Lusis, A.J. J. Lipid Res. (1993) [Pubmed]
  15. Carboxyl ester lipase cofractionates with scavenger receptor BI in hepatocyte lipid rafts and enhances selective uptake and hydrolysis of cholesteryl esters from HDL3. Camarota, L.M., Chapman, J.M., Hui, D.Y., Howles, P.N. J. Biol. Chem. (2004) [Pubmed]
  16. Dietary free and esterified cholesterol absorption in cholesterol esterase (bile salt-stimulated lipase) gene-targeted mice. Howles, P.N., Carter, C.P., Hui, D.Y. J. Biol. Chem. (1996) [Pubmed]
  17. Recombinant human bile salt-stimulated lipase: an example of defective O-glycosylation of a protein produced in milk of transgenic mice. Strömqvist, M., Törnell, J., Edlund, M., Edlund, A., Johansson, T., Lindgren, K., Lundberg, L., Hansson, L. Transgenic Res. (1996) [Pubmed]
  18. Activation of myocardial neutral triglyceride lipase and neutral cholesterol esterase by cAMP-dependent protein kinase. Goldberg, D.I., Khoo, J.C. J. Biol. Chem. (1985) [Pubmed]
  19. The tissue-specific regulation of the carboxyl ester lipase gene in exocrine pancreas differs significantly between mouse and human. Kannius-Janson, M., Lidberg, U., Bjursell, G., Nilsson, J. Biochem. J. (2000) [Pubmed]
  20. alpha4 and beta2 integrins have nonredundant roles for asthma development, but for optimal allergen sensitization only alpha4 is critical. Banerjee, E.R., Jiang, Y., Henderson, W.R., Scott, L.M., Papayannopoulou, T. Exp. Hematol. (2007) [Pubmed]
  21. Molecular cloning and characterization of the mouse carboxyl ester lipase gene and evidence for expression in the lactating mammary gland. Lidmer, A.S., Kannius, M., Lundberg, L., Bjursell, G., Nilsson, J. Genomics (1995) [Pubmed]
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