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Gene Review

Anxa2  -  annexin A2

Mus musculus

Synonyms: 36-kDa calelectrin, AW215814, Annexin A2, Annexin II, Annexin-2, ...
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Disease relevance of Anxa2

  • CONCLUSION: Collectively, these findings demonstrate that S100A6 and Anxa2 expression, initiated in response to tubular injury, persist in parallel throughout the recovery process of tubular cells in acute renal failure [1].
  • Brain and the mouse embryonal carcinoma cell line F9 contain moderate to high levels of p11 mRNA with very low levels of p36 mRNA [2].
  • Treatment of pregnant A/J strain mice with a cleft-palate inducing regimen of dexamethasone stimulated accumulation of lipocortin I protein and mRNA, but not lipocortin II (annexin II) protein [3].
  • The Lipocortin II cDNA probe detects at least four independently segregating loci which map to human chromosome regions 4q21-q31.1, 9pter-q34 proximal to c-abl, 10q proximal to 10q24 and 15q21-q22 proximal to the 15q22 translocation breakpoint characteristic of acute promyelocytic leukemia (APL) [4].
  • Interestingly, the annexin II complex, isolated from porcine small intestinal microvilli was a far better substrate for mRNA binding than the complex derived from transformed Krebs II ascites cells [5].

High impact information on Anxa2


Biological context of Anxa2


Anatomical context of Anxa2


Associations of Anxa2 with chemical compounds


Physical interactions of Anxa2


Regulatory relationships of Anxa2


Other interactions of Anxa2


Analytical, diagnostic and therapeutic context of Anxa2


  1. Calcium-binding proteins annexin A2 and S100A6 are sensors of tubular injury and recovery in acute renal failure. Cheng, C.W., Rifai, A., Ka, S.M., Shui, H.A., Lin, Y.F., Lee, W.H., Chen, A. Kidney Int. (2005) [Pubmed]
  2. cDNA sequence and tissue distribution of the mRNA for bovine and murine p11, the S100-related light chain of the protein-tyrosine kinase substrate p36 (calpactin I). Saris, C.J., Kristensen, T., D'Eustachio, P., Hicks, L.J., Noonan, D.J., Hunter, T., Tack, B.F. J. Biol. Chem. (1987) [Pubmed]
  3. Developmental regulation of various annexins in the embryonic palate of the mouse: dexamethasone affects expression of annexin-1. Chepenik, K.P., Shipman-Appasamy, P., Ahn, N., Goldowitz, D. J. Craniofac. Genet. Dev. Biol. (1995) [Pubmed]
  4. Chromosomal localization of the human genes for lipocortin I and lipocortin II. Huebner, K., Cannizzaro, L.A., Frey, A.Z., Hecht, B.K., Hecht, F., Croce, C.M., Wallner, B.P. Oncogene Res. (1988) [Pubmed]
  5. Annexin II is associated with mRNAs which may constitute a distinct subpopulation. Vedeler, A., Hollås, H. Biochem. J. (2000) [Pubmed]
  6. The cDNA sequence for the protein-tyrosine kinase substrate p36 (calpactin I heavy chain) reveals a multidomain protein with internal repeats. Saris, C.J., Tack, B.F., Kristensen, T., Glenney, J.R., Hunter, T. Cell (1986) [Pubmed]
  7. Annexin II regulates fibrin homeostasis and neoangiogenesis in vivo. Ling, Q., Jacovina, A.T., Deora, A., Febbraio, M., Simantov, R., Silverstein, R.L., Hempstead, B., Mark, W.H., Hajjar, K.A. J. Clin. Invest. (2004) [Pubmed]
  8. Secretion of Annexin II via activation of insulin receptor and insulin-like growth factor receptor. Zhao, W.Q., Chen, G.H., Chen, H., Pascale, A., Ravindranath, L., Quon, M.J., Alkon, D.L. J. Biol. Chem. (2003) [Pubmed]
  9. Complete structure of the murine p36 (annexin II) gene. Identification of mRNAs for both the murine and the human gene with alternatively spliced 5' noncoding exons. Fey, M.F., Moffat, G.J., Vik, D.P., Meisenhelder, J., Saris, C.J., Hunter, T., Tack, B.F. Biochim. Biophys. Acta (1996) [Pubmed]
  10. The annexins: specific markers of midline structures and sensory neurons in the developing murine central nervous system. Hamre, K.M., Chepenik, K.P., Goldowitz, D. J. Comp. Neurol. (1995) [Pubmed]
  11. Annexin II is a thiazolidinedione-responsive gene involved in insulin-induced glucose transporter isoform 4 translocation in 3T3-L1 adipocytes. Huang, J., Hsia, S.H., Imamura, T., Usui, I., Olefsky, J.M. Endocrinology (2004) [Pubmed]
  12. Annexin A2 binds to the localization signal in the 3' untranslated region of c-myc mRNA. Mickleburgh, I., Burtle, B., Hollås, H., Campbell, G., Chrzanowska-Lightowlers, Z., Vedeler, A., Hesketh, J. FEBS J. (2005) [Pubmed]
  13. The Npc1 mutation causes an altered expression of caveolin-1, annexin II and protein kinases and phosphorylation of caveolin-1 and annexin II in murine livers. Garver, W.S., Hossain, G.S., Winscott, M.M., Heidenreich, R.A. Biochim. Biophys. Acta (1999) [Pubmed]
  14. Analysis of CD44-containing lipid rafts: Recruitment of annexin II and stabilization by the actin cytoskeleton. Oliferenko, S., Paiha, K., Harder, T., Gerke, V., Schwärzler, C., Schwarz, H., Beug, H., Günthert, U., Huber, L.A. J. Cell Biol. (1999) [Pubmed]
  15. Corneal keratocytes: phenotypic and species differences in abundant protein expression and in vitro light-scattering. Jester, J.V., Budge, A., Fisher, S., Huang, J. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
  16. Src family kinase activation in glycosphingolipid-rich membrane domains of endothelial cells treated with oxidised low density lipoprotein. Myers, S.J., Stanley, K.K. Atherosclerosis (1999) [Pubmed]
  17. Rabbit small intestine does not contain an annexin II/caveolin 1 complex as a target for 2-azetidinone cholesterol absorption inhibitors. Kramer, W., Corsiero, D., Girbig, F., Jähne, G. Biochim. Biophys. Acta (2006) [Pubmed]
  18. Formation of the annexin II2p112 complex upon differentiation of F9 teratocarcinoma cells. Harder, T., Thiel, C., Gerke, V. J. Cell. Sci. (1993) [Pubmed]
  19. Caveolar structure and protein sorting are maintained in NIH 3T3 cells independent of glycosphingolipid depletion. Shu, L., Lee, L., Chang, Y., Holzman, L.B., Edwards, C.A., Shelden, E., Shayman, J.A. Arch. Biochem. Biophys. (2000) [Pubmed]
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