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Gene Review

Pebp1  -  phosphatidylethanolamine binding protein 1

Mus musculus

Synonyms: HCNP, HCNPpp, PEBP-1, Pbp, Pbp1, ...
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Disease relevance of Pebp1


Psychiatry related information on Pebp1


High impact information on Pebp1

  • Differentiation induction of human keratinocytes by phosphatidylethanolamine-binding protein [1].
  • Fluorescent immunostain revealed that cells expressing PEBP exhibited enlarged and flattened cell shape, and induction of involucrin expression was demonstrated by immunoblot analysis [1].
  • These results indicate that PEBP not only inhibits cell proliferation but also induces differentiation of human keratinocytes [1].
  • Since PEBP does not share significant homology with other serine protease inhibitors, our results define it as the prototype of a novel class of serine protease inhibitors [5].
  • PEBP immunoreactivity is found on the surface of Rat-1 fibroblast cells and although its sequence contains no secretion signal, PEBP-H(6) can be purified from the conditioned medium upon recombinant expression [5].

Biological context of Pebp1

  • To obtain functional evidence that supports sequence homology data, purified recombinant PEBP 1 and PEBP 2 were evaluated for biological activity [6].
  • Down-regulation of PEBP may result in lower levels of HCNP or altered coordination of signal transduction pathways that may contribute to neuronal dysfunction and pathogenesis in AD [4].
  • As mlc2a is involved in heart morphogenesis, and PEBP controls the proliferation and differentiation of different cell types, these genes are candidates for involvement in DS-CHD [2].
  • To identify gene(s) or a gene cluster on Chr 21 responsible for the downregulation of mlc2a and PEBP, we fragmented Chr 21 at the EST2 loci, by telomere-directed chromosome truncation in homologous recombination-proficient chicken DT40 cells [2].
  • Further study will be focused on phosphorylation pathways of the PEBP and its substrates [3].

Anatomical context of Pebp1

  • Immunolocalization studies revealed that DF-R/PEBP 1 is located on the acrosomal cap, the post-acrosomal region and the flagellum of both mouse and human spermatozoa, with epitope accessibility being capacitation state-dependent and reversible [6].
  • We suggest that DF-R/PEBP 1 plays its fundamental role in capacitation by causing alterations in the sperm plasma membrane in both head and flagellum, with functional consequences for membrane-associated proteins [6].
  • The current study demonstrates that PEBP is decreased in the hippocampus of 11 month Tg2576 mice, in the absence of change in mRNA levels compared to non-transgenic littermates [4].
  • Immunohistochemical studies on Tg2576 and AD brain sections demonstrate that PEBP immunoreactivities are present at the periphery of dense multicore Abeta plaques, and in selective astrocytes, primarily surrounding plaques [4].

Associations of Pebp1 with chemical compounds


Other interactions of Pebp1


Analytical, diagnostic and therapeutic context of Pebp1


  1. Differentiation induction of human keratinocytes by phosphatidylethanolamine-binding protein. Yamazaki, T., Nakano, H., Hayakari, M., Tanaka, M., Mayama, J., Tsuchida, S. J. Biol. Chem. (2004) [Pubmed]
  2. Human chromosome 21q22.2-qter carries a gene(s) responsible for downregulation of mlc2a and PEBP in Down syndrome model mice. Kazuki, Y., Kimura, M., Nishigaki, R., Kai, Y., Abe, S., Okita, C., Shirayoshi, Y., Schulz, T.C., Tomizuka, K., Hanaoka, K., Inoue, T., Oshimura, M. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  3. Practical bioinformatics for proteomics. Thongboonkerd, V., Klein, J.B. Contributions to nephrology. (2004) [Pubmed]
  4. Decreased phosphatidylethanolamine binding protein expression correlates with Abeta accumulation in the Tg2576 mouse model of Alzheimer's disease. George, A.J., Holsinger, R.M., McLean, C.A., Tan, S.S., Scott, H.S., Cardamone, T., Cappai, R., Masters, C.L., Li, Q.X. Neurobiol. Aging (2006) [Pubmed]
  5. The phosphatidylethanolamine-binding protein is the prototype of a novel family of serine protease inhibitors. Hengst, U., Albrecht, H., Hess, D., Monard, D. J. Biol. Chem. (2001) [Pubmed]
  6. A mouse sperm decapacitation factor receptor is phosphatidylethanolamine-binding protein 1. Gibbons, R., Adeoya-Osiguwa, S.A., Fraser, L.R. Reproduction (2005) [Pubmed]
  7. Promotion of cellular migration and apoptosis resistance by a mouse eye-specific phosphatidylethanolamine-binding protein. Zhang, Y., Wang, X., Xiang, Z., Li, H., Qiu, J., Sun, Q., Wan, T., Li, N., Cao, X., Wang, J. Int. J. Mol. Med. (2007) [Pubmed]
  8. Plasticity demonstrated in the proteome of a parasitic nematode within the intestine of different host strains. Morgan, C., LaCourse, E.J., Rushbrook, B.J., Greetham, D., Hamilton, J.V., Barrett, J., Bailey, K., Brophy, P.M. Proteomics (2006) [Pubmed]
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