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Gene Review

Cd53  -  Cd53 molecule

Rattus norvegicus

Synonyms: Cell surface glycoprotein CD53, Leukocyte antigen MRC OX-44, Leukocyte surface antigen CD53, OX44, Ox-44
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Disease relevance of Cd53


High impact information on Cd53

  • To study its biological role, we determined which signaling pathways are affected by the CD53 antigen, a prototypic member of this family, in rat macrophages [2].
  • A 50-60-kD glycoprotein coprecipitates with the OX-44 molecule from RNK-16 cells and rat splenic T cells [3].
  • The MRC OX-44 molecule, which is expressed on all peripheral leukocytes, identifies the subset of thymocytes capable of proliferating in response to alloantigens and lectins (Paterson, D.J., J.R. Green, W.A. Jefferies, M. Puklavec, and A.F. Williams. 1987. J. Exp. Med. 165:1) [3].
  • TCR stimulation resulted in rapid downregulation of CD4 and CD8, maintenance of a larger cell size, and induction of the CD53 antigen that marks mature and CD4,8 double-negative rat thymocytes [4].
  • Comparison of NH2-terminal protein sequence from the rat OX-44 antigen with the sequence of the human CD37 antigen deduced from a cDNA clone shows that these antigens are species homologues [5].

Biological context of Cd53


Anatomical context of Cd53


Associations of Cd53 with chemical compounds

  • Ligation of CD53 antigen with a monoclonal antibody triggered the induction of DNA synthesis, which was not sensitive to inhibitors of signaling pathways that use phosphatidylinositol 3-kinase (PI3K) and protein kinase C, or to calcium channel inhibitors, such as thapsigargin and verapamil [7].
  • The epitopes of OX-44, 6E2 and 7D2 are restored by the substitution of a single isoleucine residue for threonine at position 154 in the mouse protein [11].

Other interactions of Cd53


  1. The rat leukocyte antigen MRC OX-44 is a member of a new family of cell surface proteins which appear to be involved in growth regulation. Bellacosa, A., Lazo, P.A., Bear, S.E., Tsichlis, P.N. Mol. Cell. Biol. (1991) [Pubmed]
  2. Induction of nitric oxide release by MRC OX-44 (anti-CD53) through a protein kinase C-dependent pathway in rat macrophages. Boscá, L., Lazo, P.A. J. Exp. Med. (1994) [Pubmed]
  3. The OX-44 molecule couples to signaling pathways and is associated with CD2 on rat T lymphocytes and a natural killer cell line. Bell, G.M., Seaman, W.E., Niemi, E.C., Imboden, J.B. J. Exp. Med. (1992) [Pubmed]
  4. T cell receptor-mediated selection of functional rat CD8 T cells from defined immature thymocyte precursors in short-term suspension culture. Hünig, T., Mitnacht, R. J. Exp. Med. (1991) [Pubmed]
  5. The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen. Classon, B.J., Williams, A.F., Willis, A.C., Seed, B., Stamenkovic, I. J. Exp. Med. (1989) [Pubmed]
  6. Apoptosis protection and survival signal by the CD53 tetraspanin antigen. Yunta, M., Lazo, P.A. Oncogene (2003) [Pubmed]
  7. Induction of DNA synthesis by ligation of the CD53 tetraspanin antigen in primary cultures of mesangial cells. Yunta, M., Rodríguez-Barbero, A., Arévalo, M.A., López-Novoa, J.M., Lazo, P.A. Kidney Int. (2003) [Pubmed]
  8. An intermediate cell in thymocyte differentiation that expresses CD8 but not CD4 antigen. Paterson, D.J., Williams, A.F. J. Exp. Med. (1987) [Pubmed]
  9. Characterization of cell types during rat liver development. Fiegel, H.C., Park, J.J., Lioznov, M.V., Martin, A., Jaeschke-Melli, S., Kaufmann, P.M., Fehse, B., Zander, A.R., Kluth, D. Hepatology (2003) [Pubmed]
  10. Characterization and enrichment of fetal rat hepatoblasts by immunoadsorption ("panning") and fluorescence-activated cell sorting. Sigal, S.H., Brill, S., Reid, L.M., Zvibel, I., Gupta, S., Hixson, D., Faris, R., Holst, P.A. Hepatology (1994) [Pubmed]
  11. Epitope mapping of anti-rat CD53 monoclonal antibodies. Implications for the membrane orientation of the Transmembrane 4 Superfamily. Tomlinson, M.G., Williams, A.F., Wright, M.D. Eur. J. Immunol. (1993) [Pubmed]
  12. CD53 antigen and epidermal growth factor induce similar changes in the pattern of phorbol ester binding in a B cell lymphoma. Barcia, R., García-Vargas, S., Boscá, L., Lazo, P.A. Cell. Immunol. (1996) [Pubmed]
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