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Gene Review

Efnb1  -  ephrin B1

Rattus norvegicus

Synonyms: ELK ligand, ELK-L, EPH-related receptor tyrosine kinase ligand 2, Ephrin-B1, Eplg2, ...
 
 
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Disease relevance of Efnb1

 

High impact information on Efnb1

  • LERK-2, a binding protein for the receptor-tyrosine kinase ELK, is evolutionarily conserved and expressed in a developmentally regulated pattern [2].
  • Expression of the rat LERK-2 mRNA was detected in embryonic brain, kidney, lung, skeletal muscle, thymus, liver, and heart, and diminished in the early post-natal period [2].
  • The nucleotide sequence of the present clones is > 90% identical to the previously identified human LERK-2 cDNA, and the predicted proteins encoded by the rat and human clones are identical at 95% of amino acid residues [2].
  • Significant LERK-2 mRNA expression in the young adult rat was restricted to the lung, kidney, heart and testes [2].
  • Ephrin-B1 promotes dendrite outgrowth on cerebellar granule neurons [3].
 

Biological context of Efnb1

  • Ephrin-B reverse signaling induces expression of wound healing associated genes in IEC-6 intestinal epithelial cells [4].
  • Since previous data have indicated an involvement of ephrin-B2 in epithelial healing, we investigated the gene expression and downstream signaling pathways induced by ephrin-B mediated cell-cell signaling in intestinal epithelial cells [4].
  • METHODS: Upon stimulation of ephrin-B pathways in IEC-6 cells with recombinant rat EphB1-Fc, gene expression was analyzed by Affymetrix(R) rat genome 230 high density arrays at different time points [4].
  • RESULTS: Stimulation of the ephrin-B reverse signaling pathway in IEC-6 cells induces predominant expression of genes known to be involved into wound healing/cell migration, antiapoptotic pathways, host defense and inflammation [4].
  • CONCLUSION: Stimulation of the ephrin-B reverse signaling pathway induces a phenotype characterized by upregulation of repair-related genes, which may partially be mediated by ERK1/2 pathways [4].
 

Anatomical context of Efnb1

  • Stably transfected 3T3 cells overexpressing ephrin-B1 enhance survival and neurite growth from cultured cerebellar granule neurons, an effect that is inhibited by the presence of an excess of a soluble EphB protein [3].
  • In addition, MAP kinase pathways and focal adhesion kinase (FAK) activation downstream of ephrin-B were investigated by immunoblotting and fluorescence microscopy [4].
  • In this study we used a growth cone collapse assay to determine if the TM ligands Lerk2 and HtkL have repellant guidance activity [5].
  • Treatment with Lerk2 disrupts the organization of both the actin cytoskeleton and the microtubules and induces the formation of swellings in the center of the growth cone and along the axon [5].
  • Distribution of EphB receptors and ephrin-B1 in the developing vertebrate spinal cord [1].
 

Associations of Efnb1 with chemical compounds

 

Regulatory relationships of Efnb1

  • One exception is the adult olfactory bulb which continues to express a moderate level of LERK-2 [6].
 

Other interactions of Efnb1

  • In this study we examined the spatio-temporal expression of the Eph receptor EphB2 and its ligands, ephrin-B1 and ephrin-B2, during development of the rat primary olfactory system [7].

References

  1. Distribution of EphB receptors and ephrin-B1 in the developing vertebrate spinal cord. Jevince, A.R., Kadison, S.R., Pittman, A.J., Chien, C.B., Kaprielian, Z. J. Comp. Neurol. (2006) [Pubmed]
  2. LERK-2, a binding protein for the receptor-tyrosine kinase ELK, is evolutionarily conserved and expressed in a developmentally regulated pattern. Fletcher, F.A., Carpenter, M.K., Shilling, H., Baum, P., Ziegler, S.F., Gimpel, S., Hollingsworth, T., Vanden Bos, T., James, L., Hjerrild, K. Oncogene (1994) [Pubmed]
  3. Ephrin-B1 promotes dendrite outgrowth on cerebellar granule neurons. Moreno-Flores, M.T., Martín-Aparicio, E., Avila, J., Díaz-Nido, J., Wandosell, F. Mol. Cell. Neurosci. (2002) [Pubmed]
  4. Ephrin-B reverse signaling induces expression of wound healing associated genes in IEC-6 intestinal epithelial cells. Hafner, C., Meyer, S., Hagen, I., Becker, B., Roesch, A., Landthaler, M., Vogt, T. World J. Gastroenterol. (2005) [Pubmed]
  5. Lerk2 (ephrin-B1) is a collapsing factor for a subset of cortical growth cones and acts by a mechanism different from AL-1 (ephrin-A5). Meima, L., Moran, P., Matthews, W., Caras, I.W. Mol. Cell. Neurosci. (1997) [Pubmed]
  6. Ligands for EPH-related tyrosine kinase receptors are developmentally regulated in the CNS. Carpenter, M.K., Shilling, H., VandenBos, T., Beckmann, M.P., Cerretti, D.P., Kott, J.N., Westrum, L.E., Davison, B.L., Fletcher, F.A. J. Neurosci. Res. (1995) [Pubmed]
  7. EphB2 and two of its ligands have dynamic protein expression patterns in the developing olfactory system. St John, J.A., Key, B. Brain Res. Dev. Brain Res. (2001) [Pubmed]
 
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