The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

act1  -  actin Act1

Schizosaccharomyces pombe 972h-

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on act1


Biological context of act1


Anatomical context of act1

  • Actin point-mutant cps8 cells have abnormal structure in the cell wall and septum, and the distribution pattern of the actin cytoskeleton during the reversion process was different from wild-type protoplasts [9].
  • A Schizosaccharomyces pombe cps8 mutant, of which the gene encodes a mutant actin with an amino acid substitution of Asp for Gly(273) [J. Ishiguro and W. Kobayashi (1996) FEBS Lett. 392, 237-241], was used to determine the role of the actin cytoskeleton in cell wall formation [10].
  • Overexpression of the oligomerization domain in cultured cells was accompanied by major alterations in cellular morphology, actin organization, and the structure of focal adhesions, suggesting that an orderly coming together of FAP52 molecules is crucial for a proper actin filament organization and cytoskeletal structure [11].
  • The protoplast of the cps8 mutant began to form a glucan network in a unipolar manner and to secrete alpha-galactomannan [12].

Associations of act1 with chemical compounds

  • These results suggest that the cps8 mutant was insufficient in developing cross-linkage with the glucan fibrils up to the wide ribbon shape as found in the wild-type [Osumi M et al. (1989) J. Electron Microsc. 38: 457-468; Osumi M (1998) Micron 29: 207-233] [12].

Other interactions of act1

  • Differences between the 3'-processing sequences were observed, with transcription termination mediated by the ura4 3' region being more efficient than termination by the 3' regions of adh1 and act1 [13].


  1. The fission yeast cytokinesis formin Cdc12p is a barbed end actin filament capping protein gated by profilin. Kovar, D.R., Kuhn, J.R., Tichy, A.L., Pollard, T.D. J. Cell Biol. (2003) [Pubmed]
  2. The Schizosaccharomyces pombe cdc3+ gene encodes a profilin essential for cytokinesis. Balasubramanian, M.K., Hirani, B.R., Burke, J.D., Gould, K.L. J. Cell Biol. (1994) [Pubmed]
  3. mRNA binding protein mrnp 41 localizes to both nucleus and cytoplasm. Kraemer, D., Blobel, G. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  4. Identification of act2, an essential gene in the fission yeast Schizosaccharomyces pombe that encodes a protein related to actin. Lees-Miller, J.P., Henry, G., Helfman, D.M. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  5. Dynamics of the formin for3p in actin cable assembly. Martin, S.G., Chang, F. Curr. Biol. (2006) [Pubmed]
  6. Endocytosis in fission yeast is spatially associated with the actin cytoskeleton during polarised cell growth and cytokinesis. Gachet, Y., Hyams, J.S. J. Cell. Sci. (2005) [Pubmed]
  7. An actin point-mutation neighboring the 'hydrophobic plug' causes defects in the maintenance of cell polarity and septum organization in the fission yeast Schizosaccharomyces pombe. Ishiguro, J., Kobayashi, W. FEBS Lett. (1996) [Pubmed]
  8. Role of MMM1 in maintaining mitochondrial morphology in Neurospora crassa. Prokisch, H., Neupert, W., Westermann, B. Mol. Biol. Cell (2000) [Pubmed]
  9. Dynamics of cell wall formation in fission yeast, Schizosaccharomyces pombe. Osumi, M., Sato, M., Ishijima, S.A., Konomi, M., Takagi, T., Yaguchi, H. Fungal Genet. Biol. (1998) [Pubmed]
  10. Ultrastructure of cell wall of the cps8 actin mutant cell in Schizosaccharomyces pombe. Ishijima, S.A., Konomi, M., Takagi, T., Sato, M., Ishiguro, J., Osumi, M. FEMS Microbiol. Lett. (1999) [Pubmed]
  11. Focal adhesion protein FAP52 self-associates through a sequence conserved among the members of the PCH family proteins. Nikki, M., Meriläinen, J., Lehto, V.P. Biochemistry (2002) [Pubmed]
  12. Abnormal formation of the glucan network from regenerating protoplasts in Schizosaccharomyces pombe cps8 actin point mutant. Konomi, M., Ishiguro, J., Osumi, M. Journal of electron microscopy. (2000) [Pubmed]
  13. Comparison of three 3' non-coding regions in Schizosaccharomyces pombe expression vectors: efficiencies of transcription termination and mRNA 3'-end formation. Patrikakis, M., Izant, J.G., Atkins, D. Curr. Genet. (1996) [Pubmed]
WikiGenes - Universities