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Gene Review

Actg1  -  actin, gamma 1

Rattus norvegicus

Synonyms: Actg, Actin, cytoplasmic 2, Gamma-actin
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Disease relevance of Actg1


High impact information on Actg1


Biological context of Actg1


Anatomical context of Actg1


Associations of Actg1 with chemical compounds

  • Glucose stimulated the steady state of c-myc mRNA transcripts in a dose-responsive manner without any change of gamma-actin mRNA levels after 2 h of treatment [12].
  • The cDNAs which were specific for beta and gamma actin isoforms yielded hybridization signals in extracts from CMC exposed to 10(-7) M and 10(-6) M ADR [13].
  • Corticosterone administration, which is known to impair the reinnervation process in ECL rats, prevents the lesion-induced reduction in gamma-actin expression and blocks the induction of alpha 1-tubulin in the deafferented hippocampus [14].
  • Regulation of beta- and gamma-actin mRNA by thyroid hormone in the developing rat brain [3].
  • In polypeptides extracted in the Triton X-100-soluble pool, the effect on CMC alpha-actin synthesis was greater than the effect on beta- or gamma-actin [15].

Regulatory relationships of Actg1

  • The rats of transcription of both beta- and gamma-actin mRNAs were stimulated by T3 during the early phase but that of beta-actin mRNAs was relatively more sensitive to T3 than gamma-actin mRNA [3].

Other interactions of Actg1


Analytical, diagnostic and therapeutic context of Actg1


  1. Structure, chromosome location, and expression of the human smooth muscle (enteric type) gamma-actin gene: evolution of six human actin genes. Miwa, T., Manabe, Y., Kurokawa, K., Kamada, S., Kanda, N., Bruns, G., Ueyama, H., Kakunaga, T. Mol. Cell. Biol. (1991) [Pubmed]
  2. Regulation of gamma-actin gene expression by insulin. Messina, J.L. J. Cell. Physiol. (1994) [Pubmed]
  3. Regulation of beta- and gamma-actin mRNA by thyroid hormone in the developing rat brain. Sarkar, S., Chaudhury, S., Sarkar, P.K. Neuroreport (1997) [Pubmed]
  4. Isoform distribution and tissue contents of contractile and cytoskeletal proteins in hypertrophied smooth muscle from rat portal vein. Malmqvist, U., Arner, A. Circ. Res. (1990) [Pubmed]
  5. Sorting of beta-actin mRNA and protein to neurites and growth cones in culture. Bassell, G.J., Zhang, H., Byrd, A.L., Femino, A.M., Singer, R.H., Taneja, K.L., Lifshitz, L.M., Herman, I.M., Kosik, K.S. J. Neurosci. (1998) [Pubmed]
  6. The molecular composition of neuronal microfilaments is spatially and temporally regulated. Weinberger, R., Schevzov, G., Jeffrey, P., Gordon, K., Hill, M., Gunning, P. J. Neurosci. (1996) [Pubmed]
  7. Effect of estrogen on the expression of mRNAs of different actin isoforms in immature rat uterus. Cloning of alpha-smooth muscle actin message. Hsu, C.Y., Frankel, F.R. J. Biol. Chem. (1987) [Pubmed]
  8. Skeletal muscle myofibrillogenesis as revealed with a monoclonal antibody to titin in combination with detection of the alpha- and gamma-isoforms of actin. Handel, S.E., Wang, S.M., Greaser, M.L., Schultz, E., Bulinski, J.C., Lessard, J.L. Dev. Biol. (1989) [Pubmed]
  9. Expression and localization of alpha-smooth muscle and gamma-actins in the pregnant rat myometrium. Shynlova, O., Tsui, P., Dorogin, A., Chow, M., Lye, S.J. Biol. Reprod. (2005) [Pubmed]
  10. beta-Actin is confined to structures having high capacity of remodelling in developing and adult rat cerebellum. Micheva, K.D., Vallée, A., Beaulieu, C., Herman, I.M., Leclerc, N. Eur. J. Neurosci. (1998) [Pubmed]
  11. Actin mRNA isoforms are differentially sorted in normal osteoblasts and sorting is altered in osteoblasts from a skeletal mutation in the rat. Watanabe, H., Kislauskis, E.H., Mackay, C.A., Mason-Savas, A., Marks, S.C. J. Cell. Sci. (1998) [Pubmed]
  12. Glucose stimulation of protooncogene expression and deoxyribonucleic acid synthesis in rat islet cell line. Yamashita, S., Tobinaga, T., Ashizawa, K., Nagayama, Y., Yokota, A., Harakawa, S., Inoue, S., Hirayu, H., Izumi, M., Nagataki, S. Endocrinology (1988) [Pubmed]
  13. Actin isoform mRNA alterations induced by doxorubicin in cultured heart cells. Lewis, W., Gonzalez, B. Lab. Invest. (1990) [Pubmed]
  14. Modulation of gamma-actin and alpha 1-tubulin expression by corticosterone during neuronal plasticity in the hippocampus. Poirier, J., Dea, D., Baccichet, A., Gauthier, S. Brain Res. Mol. Brain Res. (1992) [Pubmed]
  15. Alpha-actin synthesis changes in cultured cardiac myocytes: relationship to anthracycline structure. Lewis, W., Perillo, N.L., Gonzalez, B. J. Lab. Clin. Med. (1988) [Pubmed]
  16. Increased beta-actin and tubulin polymerization in regrowing axons: relationship to the conditioning lesion effect. Lund, L.M., Machado, V.M., McQuarrie, I.G. Exp. Neurol. (2002) [Pubmed]
  17. The participation of tumor necrosis factor in the pathogenesis of lung allograft rejection in the rat. Saito, R., Prehn, J., Zuo, X.J., Marchevesky, A., Castracane, J., Waters, P., Matloff, J., Jordan, S.C. Transplantation (1993) [Pubmed]
  18. Transfection with c-Ha rasEJ modulates alpha-actin and alpha 1B-adrenoceptor gene expression in vascular smooth muscle cells. Lundberg, M.S., Sadhu, D.N., Chilian, W.M., Ramos, K.S. J. Mol. Cell. Cardiol. (1997) [Pubmed]
  19. Expression of the AMF/neuroleukin receptor in developing and adult brain cerebellum. Leclerc, N., Vallée, A., Nabi, I.R. J. Neurosci. Res. (2000) [Pubmed]
  20. The golgi-associated COPI-coated buds and vesicles contain beta/gamma -actin. Valderrama, F., Luna, A., Babía, T., Martinez-Menárguez, J.A., Ballesta, J., Barth, H., Chaponnier, C., Renau-Piqueras, J., Egea, G. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  21. TRPM-2 gene expression in normal rat ventral prostate following castration and exposure to diethylstilbestrol, flutamide, MK-906 (finasteride), and coumarin. Russo, P., Warner, J.A., Huryk, R., Perez, G., Heston, W.D. Prostate (1994) [Pubmed]
  22. Molecular beacons for DNA biosensors with micrometer to submicrometer dimensions. Liu, X., Farmerie, W., Schuster, S., Tan, W. Anal. Biochem. (2000) [Pubmed]
  23. Proteomic identification of a large complement of rat urinary proteins. Thongboonkerd, V., Klein, J.B., Arthur, J.M. Nephron Exp. Nephrol. (2003) [Pubmed]
  24. In vitro synthesis of beta- and gamma-isoactins by messenger RNA of rat ascites hepatoma. Sakiyama, S., Okiba, N., Fujimura, S. Biochim. Biophys. Acta (1980) [Pubmed]
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