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Gene Review

NCU04173  -  actin

Neurospora crassa OR74A

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High impact information on NCU04173.1

  • These genes encode novel proteins as well as proteins which 1) regulate the actin or microtubule cytoskeleton, 2) are kinases or components of signal transduction pathways, 3) are part of the secretory pathway, or 4) have functions in cell wall formation or membrane biosynthesis [1].
  • Null mutants of the neurospora actin-related protein 1 pointed-end complex show distinct phenotypes [2].
  • The ability to assemble cytoplasmic microtubules and actin is maintained in ro-2 mutants, although subapical actin patches are more prominent [3].
  • In contrast, the accumulation of mRNAs encoding beta-tubulin, actin, or glyceraldehyde-3-phosphate dehydrogenase was not appreciably altered by either the presence of a hypovirulence-associated virus or treatment with cycloheximide [4].
  • Actin has a pivotal function in hyphal morphogenesis in filamentous fungi, but it is not certain whether its function is equivalent to that of a morphogen, or if it is simply part of a mechanism that executes orders given by another regulatory entity [5].

Biological context of NCU04173.1


Anatomical context of NCU04173.1


Associations of NCU04173.1 with chemical compounds


Analytical, diagnostic and therapeutic context of NCU04173.1


  1. The genetic basis of cellular morphogenesis in the filamentous fungus Neurospora crassa. Seiler, S., Plamann, M. Mol. Biol. Cell (2003) [Pubmed]
  2. Null mutants of the neurospora actin-related protein 1 pointed-end complex show distinct phenotypes. Lee, I.H., Kumar, S., Plamann, M. Mol. Biol. Cell (2001) [Pubmed]
  3. A gene required for nuclear migration in Neurospora crassa codes for a protein with cysteine-rich, LIM/RING-like domains. Vierula, P.J., Mais, J.M. Mol. Microbiol. (1997) [Pubmed]
  4. Molecular analysis of the laccase gene from the chestnut blight fungus and selective suppression of its expression in an isogenic hypovirulent strain. Choi, G.H., Larson, T.G., Nuss, D.L. Mol. Plant Microbe Interact. (1992) [Pubmed]
  5. A mutation in the Neurospora crassa actin gene results in multiple defects in tip growth and branching. Virag, A., Griffiths, A.J. Fungal Genet. Biol. (2004) [Pubmed]
  6. Temperature adaptation of house keeping and heat shock gene expression in Neurospora crassa. Mohsenzadeh, S., Saupe-Thies, W., Steier, G., Schroeder, T., Fracella, F., Ruoff, P., Rensing, L. Fungal Genet. Biol. (1998) [Pubmed]
  7. Actin modulates the gating of Neurospora crassa VDAC. Xu, X., Forbes, J.G., Colombini, M. J. Membr. Biol. (2001) [Pubmed]
  8. Purification of a 47-kDa calmodulin-binding polypeptide as an actin-binding protein from Neurospora crassa. Capelli, N., Barja, F., van Tuinen, D., Monnat, J., Turian, G., Ortega Perez, R. FEMS Microbiol. Lett. (1997) [Pubmed]
  9. Regulation of the tip-high [Ca2+] gradient in growing hyphae of the fungus Neurospora crassa. Silverman-Gavrila, L.B., Lew, R.R. Eur. J. Cell Biol. (2001) [Pubmed]
  10. What determines growth direction in fungal hyphae? Riquelme, M., Reynaga-Peña, C.G., Gierz, G., Bartnicki-García, S. Fungal Genet. Biol. (1998) [Pubmed]
  11. Localization of actin and characterization of its isoforms in the hyphae of Neurospora crassa. Barja, F., Thi, B.N., Turian, G. FEMS Microbiol. Lett. (1991) [Pubmed]
  12. A putative spectrin-containing membrane skeleton in hyphal tips of Neurospora crassa. Degousée, N., Gupta, G.D., Lew, R.R., Heath, I.B. Fungal Genet. Biol. (2000) [Pubmed]
  13. Immunocharacterization of actin and its immunofluorescent localization during the developmental gametophytic stages of Allomyces arbuscula. Nguyen Thi, B.N., Turian, G. FEMS Microbiol. Lett. (1992) [Pubmed]
  14. Direct measurement of VDAC-actin interaction by surface plasmon resonance. Roman, I., Figys, J., Steurs, G., Zizi, M. Biochim. Biophys. Acta (2006) [Pubmed]
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