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Gene Review

Emap  -  microtubule-associated protein

Rattus norvegicus

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Disease relevance of Emap


Psychiatry related information on Emap


High impact information on Emap


Chemical compound and disease context of Emap


Biological context of Emap


Anatomical context of Emap


Associations of Emap with chemical compounds

  • Moreover, they indicate that alteration in the properties of a microtubule-associated protein may account for some of the effects of glutamate on postsynaptic neurons [21].
  • Activation of NMDA receptors induces rapid dephosphorylation of the cytoskeletal protein MAP2 [21].
  • In this study, the effects of long- and short-term ethanol exposure on vesicle movements were measured in isolated hepatocytes, and alterations in the function of the microtubule-associated motor enzymes dynamin, kinesin, and dynein, which are believed to support the transport and/or budding of vesicles along microtubules, were tested [25].
  • We conclude that FCCP could depolymerise microtubules in vivo through a dual operation: increasing the intracellular pH by the disruption of the mitochondrial H+ gradient and decreasing the stability of microtubules by impairing the binding of microtubule-associated proteins [26].
  • Ring formation is not sensitive to taxol, colchicine, or microtubule-associated proteins, but requires Mg(2+) and is inhibited by maytansine [27].

Physical interactions of Emap


Enzymatic interactions of Emap


Co-localisations of Emap


Regulatory relationships of Emap


Other interactions of Emap


Analytical, diagnostic and therapeutic context of Emap


  1. A cloned cDNA encoding MAP1 detects a single copy gene in mouse and a brain-abundant RNA whose level decreases during development. Lewis, S.A., Sherline, P., Cowan, N.J. J. Cell Biol. (1986) [Pubmed]
  2. Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress. Stamer, K., Vogel, R., Thies, E., Mandelkow, E., Mandelkow, E.M. J. Cell Biol. (2002) [Pubmed]
  3. Alterations in tau immunostaining in the rat hippocampus following transient cerebral ischemia. Geddes, J.W., Schwab, C., Craddock, S., Wilson, J.L., Pettigrew, L.C. J. Cereb. Blood Flow Metab. (1994) [Pubmed]
  4. Binding of adenovirus to microtubules. II. Depletion of high-molecular-weight microtubule-associated protein content reduces specificity of in vitro binding. Weatherbee, J.A., Luftig, R.B., Weihing, R.R. J. Virol. (1977) [Pubmed]
  5. Upregulation of MAP1B and MAP2 in the rat brain after middle cerebral artery occlusion: effect of age. Popa-Wagner, A., Schröder, E., Schmoll, H., Walker, L.C., Kessler, C. J. Cereb. Blood Flow Metab. (1999) [Pubmed]
  6. Brefeldin A causes a microtubule-mediated fusion of the trans-Golgi network and early endosomes. Wood, S.A., Park, J.E., Brown, W.J. Cell (1991) [Pubmed]
  7. Tau cleavage and dephosphorylation in cerebellar granule neurons undergoing apoptosis. Canu, N., Dus, L., Barbato, C., Ciotti, M.T., Brancolini, C., Rinaldi, A.M., Novak, M., Cattaneo, A., Bradbury, A., Calissano, P. J. Neurosci. (1998) [Pubmed]
  8. Changes in mRNA abundance of microtubule-associated proteins in the rat brain following electroconvulsive shock. Pei, Q., Burnet, P.J., Zetterström, T.S. Neuroreport (1998) [Pubmed]
  9. MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption. Drewes, G., Ebneth, A., Preuss, U., Mandelkow, E.M., Mandelkow, E. Cell (1997) [Pubmed]
  10. Embryonic MAP2 lacks the cross-linking sidearm sequences and dendritic targeting signal of adult MAP2. Papandrikopoulou, A., Doll, T., Tucker, R.P., Garner, C.C., Matus, A. Nature (1989) [Pubmed]
  11. Selective localization of messenger RNA for cytoskeletal protein MAP2 in dendrites. Garner, C.C., Tucker, R.P., Matus, A. Nature (1988) [Pubmed]
  12. A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development. Kamiya, A., Kubo, K., Tomoda, T., Takaki, M., Youn, R., Ozeki, Y., Sawamura, N., Park, U., Kudo, C., Okawa, M., Ross, C.A., Hatten, M.E., Nakajima, K., Sawa, A. Nat. Cell Biol. (2005) [Pubmed]
  13. Characterization of KIFC2, a neuronal kinesin superfamily member in mouse. Hanlon, D.W., Yang, Z., Goldstein, L.S. Neuron (1997) [Pubmed]
  14. Nitrous oxide attenuates the protective effect of isoflurane on microtubule-associated protein2 degradation during forebrain ischemia in the rat. Sugaya, T., Kitani, Y. Brain Res. Bull. (1997) [Pubmed]
  15. Glucose-induced phosphorylation of the insulin receptor. Functional effects and characterization of phosphorylation sites. Pillay, T.S., Xiao, S., Olefsky, J.M. J. Clin. Invest. (1996) [Pubmed]
  16. Microtubule-associated protein 1 light chain 3 is a fibronectin mRNA-binding protein linked to mRNA translation in lamb vascular smooth muscle cells. Zhou, B., Boudreau, N., Coulber, C., Hammarback, J., Rabinovitch, M. J. Clin. Invest. (1997) [Pubmed]
  17. Cytoskeletal architecture and immunocytochemical localization of microtubule-associated proteins in regions of axons associated with rapid axonal transport: the beta,beta'-iminodipropionitrile-intoxicated axon as a model system. Hirokawa, N., Bloom, G.S., Vallee, R.B. J. Cell Biol. (1985) [Pubmed]
  18. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., Yoshimori, T. EMBO J. (2000) [Pubmed]
  19. A novel pool of protein phosphatase 2A is associated with microtubules and is regulated during the cell cycle. Sontag, E., Nunbhakdi-Craig, V., Bloom, G.S., Mumby, M.C. J. Cell Biol. (1995) [Pubmed]
  20. Postsynaptic mechanisms for bidirectional control of MAP2 phosphorylation by glutamate receptors. Quinlan, E.M., Halpain, S. Neuron (1996) [Pubmed]
  21. Activation of NMDA receptors induces rapid dephosphorylation of the cytoskeletal protein MAP2. Halpain, S., Greengard, P. Neuron (1990) [Pubmed]
  22. Selective inhibition of responses to nerve growth factor and of microtubule-associated protein phosphorylation by activators of adenylate cyclase. Greene, L.A., Drexler, S.A., Connolly, J.L., Rukenstein, A., Green, S.H. J. Cell Biol. (1986) [Pubmed]
  23. Microtubule protein preparations from C6 glial cells and their spontaneous polymer formation. Wiche, G., Honig, L.S., Cole, R.D. J. Cell Biol. (1979) [Pubmed]
  24. Regulation of a high molecular weight microtubule-associated protein in PC12 cells by nerve growth factor. Greene, L.A., Liem, R.K., Shelanski, M.L. J. Cell Biol. (1983) [Pubmed]
  25. Vesicle movement in rat hepatocytes is reduced by ethanol exposure: alterations in microtubule-based motor enzymes. Török, N., Marks, D., Hsiao, K., Oswald, B.J., McNiven, M.A. Gastroenterology (1997) [Pubmed]
  26. In vivo and in vitro effects of the mitochondrial uncoupler FCCP on microtubules. Maro, B., Marty, M.C., Bornens, M. EMBO J. (1982) [Pubmed]
  27. HIV-1 rev depolymerizes microtubules to form stable bilayered rings. Watts, N.R., Sackett, D.L., Ward, R.D., Miller, M.W., Wingfield, P.T., Stahl, S.S., Steven, A.C. J. Cell Biol. (2000) [Pubmed]
  28. Monoclonal antibody G10 against microtubule-associated protein 1x distinguishes between growing and regenerating axons. Woodhams, P.L., Calvert, R., Dunnett, S.B. Neuroscience (1989) [Pubmed]
  29. Separation of endogenous calmodulin- and cAMP-dependent kinases from microtubule preparations. Vallano, M.L., Goldenring, J.R., Buckholz, T.M., Larson, R.E., DeLorenzo, R.J. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  30. Nerve growth factor and fibroblast growth factor selectively activate a protein kinase that phosphorylates high molecular weight microtubule-associated proteins. Detection, partial purification, and characterization in PC12 cells. Tsao, H., Aletta, J.M., Greene, L.A. J. Biol. Chem. (1990) [Pubmed]
  31. A microtubule-associated protein (MAP1) which is expressed at elevated levels during development of the rat cerebellum. Calvert, R., Anderton, B.H. EMBO J. (1985) [Pubmed]
  32. Brain-derived neurotrophic factor promotes the differentiation of various hippocampal nonpyramidal neurons, including Cajal-Retzius cells, in organotypic slice cultures. Marty, S., Carroll, P., Cellerino, A., Castrén, E., Staiger, V., Thoenen, H., Lindholm, D. J. Neurosci. (1996) [Pubmed]
  33. Stimulation of the phosphorylation of cytoskeletal 350-kDa and 300-kDa proteins by insulin-like growth factor-I, platelet-derived growth factor and phorbol ester in rat 3Y1 cells. Nishida, E., Tobe, K., Kadowaki, T., Kasuga, M., Sato, C., Sakai, H. Cell Struct. Funct. (1988) [Pubmed]
  34. The adult rat olfactory system expresses microtubule-associated proteins found in the developing brain. Viereck, C., Tucker, R.P., Matus, A. J. Neurosci. (1989) [Pubmed]
  35. MAPK signal transduction pathway mediates agrin effects on neurite elongation in cultured hippocampal neurons. Karasewski, L., Ferreira, A. J. Neurobiol. (2003) [Pubmed]
  36. Microtubule-associated-protein (MAP) kinase activated by nerve growth factor and epidermal growth factor in PC12 cells. Identity with the mitogen-activated MAP kinase of fibroblastic cells. Gotoh, Y., Nishida, E., Yamashita, T., Hoshi, M., Kawakami, M., Sakai, H. Eur. J. Biochem. (1990) [Pubmed]
  37. Direct targeting of hippocampal neurons for apoptosis by glucocorticoids is reversible by mineralocorticoid receptor activation. Crochemore, C., Lu, J., Wu, Y., Liposits, Z., Sousa, N., Holsboer, F., Almeida, O.F. Mol. Psychiatry (2005) [Pubmed]
  38. The topography and subcellular distribution of mitogen-activated protein kinase kinase1 (MEK1) in adult rat brain and differentiating PC12 cells. Schipper, H.M., Agarwal-Mawal, A., Paudel, H.K. Neuroscience (1999) [Pubmed]
  39. Extracellular signal-regulated protein kinase signaling is uncoupled from initial differentiation of central nervous system stem cells to neurons. Enarsson, M., Erlandsson, A., Larsson, H., Forsberg-Nilsson, K. Mol. Cancer Res. (2002) [Pubmed]
  40. Neuraxin, a novel putative structural protein of the rat central nervous system that is immunologically related to microtubule-associated protein 5. Rienitz, A., Grenningloh, G., Hermans-Borgmeyer, I., Kirsch, J., Littauer, U.Z., Prior, P., Gundelfinger, E.D., Schmitt, B., Betz, H. EMBO J. (1989) [Pubmed]
  41. The response of synaptophysin and microtubule-associated protein 1 to restraint stress in rat hippocampus and its modulation by venlafaxine. Xu, H., He, J., Richardson, J.S., Li, X.M. J. Neurochem. (2004) [Pubmed]
  42. Molecular cloning of the microtubule-associated mechanochemical enzyme dynamin reveals homology with a new family of GTP-binding proteins. Obar, R.A., Collins, C.A., Hammarback, J.A., Shpetner, H.S., Vallee, R.B. Nature (1990) [Pubmed]
  43. GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeleton. Wang, H., Bedford, F.K., Brandon, N.J., Moss, S.J., Olsen, R.W. Nature (1999) [Pubmed]
  44. Activation of the AT(2) receptor of angiotensin II induces neurite outgrowth and cell migration in microexplant cultures of the cerebellum. Côté, F., Do, T.H., Laflamme, L., Gallo, J.M., Gallo-Payet, N. J. Biol. Chem. (1999) [Pubmed]
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