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Gene Review

HIGD1A  -  HIG1 hypoxia inducible domain family,...

Homo sapiens

Synonyms: DKFZP564K247, HIG1, HIG1 domain family member 1A, mitochondrial, HSPC010, Hypoxia-inducible gene 1 protein, ...
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Disease relevance of HIGD1A


High impact information on HIGD1A


Biological context of HIGD1A


Anatomical context of HIGD1A


Associations of HIGD1A with chemical compounds


Other interactions of HIGD1A

  • The finding suggest that STAT3-dependent pathway is involved in the activation and proliferation of PASMC stimulated by hypoxia, and SOCS3 is a rapidly hypoxia-inducible gene and acts to inhibit activation of cellular signaling pathway in a classical negative feedback loop [17].

Analytical, diagnostic and therapeutic context of HIGD1A

  • In addition, tumor xenografts derived from human cervical cancer cells display increased expression of HIG1 and HIG2 when they are deprived of oxygen [1].


  1. Epigenetic regulation of gene expression in cervical cancer cells by the tumor microenvironment. Denko, N., Schindler, C., Koong, A., Laderoute, K., Green, C., Giaccia, A. Clin. Cancer Res. (2000) [Pubmed]
  2. Hypoxia modulated gene expression: angiogenesis, metastasis and therapeutic exploitation. Dachs, G.U., Tozer, G.M. Eur. J. Cancer (2000) [Pubmed]
  3. Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression. Makino, Y., Cao, R., Svensson, K., Bertilsson, G., Asman, M., Tanaka, H., Cao, Y., Berkenstam, A., Poellinger, L. Nature (2001) [Pubmed]
  4. A Fenton reaction at the endoplasmic reticulum is involved in the redox control of hypoxia-inducible gene expression. Liu, Q., Berchner-Pfannschmidt, U., Möller, U., Brecht, M., Wotzlaw, C., Acker, H., Jungermann, K., Kietzmann, T. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  5. Carcinogenic metals induce hypoxia-inducible factor-stimulated transcription by reactive oxygen species-independent mechanism. Salnikow, K., Su, W., Blagosklonny, M.V., Costa, M. Cancer Res. (2000) [Pubmed]
  6. Hypoxia modifies the transcriptome of primary human monocytes: modulation of novel immune-related genes and identification of CC-chemokine ligand 20 as a new hypoxia-inducible gene. Bosco, M.C., Puppo, M., Santangelo, C., Anfosso, L., Pfeffer, U., Fardin, P., Battaglia, F., Varesio, L. J. Immunol. (2006) [Pubmed]
  7. Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis. Lu, H., Forbes, R.A., Verma, A. J. Biol. Chem. (2002) [Pubmed]
  8. Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1 alpha-subunit (HIF-1alpha). Characterization of hif-1alpha-dependent and -independent hypoxia-inducible gene expression. Wood, S.M., Wiesener, M.S., Yeates, K.M., Okada, N., Pugh, C.W., Maxwell, P.H., Ratcliffe, P.J. J. Biol. Chem. (1998) [Pubmed]
  9. Hypoxic induction of human visfatin gene is directly mediated by hypoxia-inducible factor-1. Bae, S.K., Kim, S.R., Kim, J.G., Kim, J.Y., Koo, T.H., Jang, H.O., Yun, I., Yoo, M.A., Bae, M.K. FEBS Lett. (2006) [Pubmed]
  10. Hypoxia-inducible gene expression system using the erythropoietin enhancer and 3'-untranslated region for the VEGF gene therapy. Lee, M., Choi, D., Choi, M.J., Jeong, J.H., Kim, W.J., Oh, S., Kim, Y.H., Bull, D.A., Kim, S.W. Journal of controlled release : official journal of the Controlled Release Society. (2006) [Pubmed]
  11. Hypoxia-inducible factor 1 transactivates the human leptin gene promoter. Grosfeld, A., Andre, J., Hauguel-De Mouzon, S., Berra, E., Pouyssegur, J., Guerre-Millo, M. J. Biol. Chem. (2002) [Pubmed]
  12. A novel adenoviral vector which mediates hypoxia-inducible gene expression selectively in neurons. Huang, D., Desbois, A., Hou, S.T. Gene Ther. (2005) [Pubmed]
  13. A hypoxia-inducible gene expression system using erythropoietin 3' untranslated region for the gene therapy of rat spinal cord injury. Choi, B.H., Ha, Y., Ahn, C.H., Huang, X., Kim, J.M., Park, S.R., Park, H., Park, H.C., Kim, S.W., Lee, M. Neurosci. Lett. (2007) [Pubmed]
  14. Hypoxia increases leptin expression in human PAZ6 adipose cells. Grosfeld, A., Zilberfarb, V., Turban, S., André, J., Guerre-Millo, M., Issad, T. Diabetologia (2002) [Pubmed]
  15. Regulation of insulin-like growth factor-binding protein-1 by nitric oxide under hypoxic conditions. Sugawara, J., Suh, D.S., Faessen, G.H., Suen, L.F., Shibata, T., Kaper, F., Giaccia, A.J., Giudice, L.C. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  16. Apigenin suppresses the expression of VEGF, an important factor for angiogenesis, in endothelial cells via degradation of HIF-1alpha protein. Osada, M., Imaoka, S., Funae, Y. FEBS Lett. (2004) [Pubmed]
  17. SOCS3 was induced by hypoxia and suppressed STAT3 phosphorylation in pulmonary arterial smooth muscle cells. Bai, L., Yu, Z., Qian, G., Qian, P., Jiang, J., Wang, G., Bai, C. Respiratory physiology & neurobiology. (2006) [Pubmed]
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