The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

MOXD1  -  monooxygenase, DBH-like 1

Homo sapiens

Synonyms: DBH-like monooxygenase protein 1, DKFZP564G202, MOX, Monooxygenase X, PRO5780, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of MOXD1

 

High impact information on MOXD1

  • MOX has all of the residues expected to be critical for copper binding, and its cysteine residues can yield the intramolecular disulfide bond pattern observed in DBM [3].
  • Despite the presence of a signal sequence, exogenous MOX is not secreted, and it localizes throughout the endoplasmic reticulum in both endocrine or nonendocrine cells [3].
  • MOX transcripts are widely expressed, with the highest levels in the salivary gland and ovary and moderate levels in brain, pituitary, and heart [3].
  • In contrast, trichostatin A dramatically potentiated MOX induction of the stably integrated VIT-CAT reporter gene, resulting in MOX-ER-dependent increases in CAT activity of up to 600-fold [4].
  • We examined the effect of ibotenate on macrocyclic lactone binding in more detail and found that it caused a 7-fold enhancement in [ 3H ] IVM binding affinity and a 4-fold increase in [ 3H ] MOX binding affinity [5].
 

Biological context of MOXD1

  • The gene for MOX resides on the q arm of chromosome 6 and the corresponding mouse homolog has been identified [6].
  • MOX mRNA levels are elevated in some fibroblast cell strains at replicative senescence, through this regulation is not apparent in all primary cell strains [6].
  • MOX maintains many of the structural features of DBH, as evidenced by the retention of most of the disulfide linkages and all of the peptidyl ligands to the active site copper atoms [6].
  • The steady-state mRNA levels of MOX are highest in the kidney, lung, and adrenal gland, indicating that the tissue distribution of MOX is broader than that of DBH [6].
  • Patients received either MOX (0.2 - 0.6 mg/d) or MET (50 - 150 mg/d) for 12 weeks, intending comparable blood pressure control [1].
 

Anatomical context of MOXD1

  • The three ER-positive HepG2ERV cell lines and wild-type, ER-negative, HepG2 cells cotransfected with cytomegalovirus-hERalpha exhibited similar MOX-dependent inductions of 20- to 50-fold with a transiently transfected VIT-luciferase reporter and 15- to 50-fold with a transfected 4-estrogen response element-TATA-luciferase reporter gene [4].
 

Associations of MOXD1 with chemical compounds

  • However, fasting plasma glucose decreased in the MOX group (median change - 5 mg/dl), but increased in the MET group (+ 16 mg/dl; p < 0.05) [1].
  • Practically all Y. enterocolitica O3 strains, whether from primary or cold enrichment cultures, were pathogenic not only on the basis of the serotype but also on the basis of Congo-red uptake and calcium-dependent growth at 35 degrees C (CR-MOX test) [7].
  • In this randomised, double-blind multicenter study, the effects of two widely used antihypertensive agents--moxonidine (MOX) and the beta (1)-selective adrenergic receptor blocker metoprolol (MET)--on blood pressure and metabolic control were directly compared in hypertensive subjects with type 2 diabetes [1].
  • These are the ERU (enriched recycled uranium) and the MOX (mixed oxide) fuel assemblies [8].
  • Here, the MOX promoter derived from another key gene of methanol metabolism is used for expression control [9].
 

Analytical, diagnostic and therapeutic context of MOXD1

  • Antisera raised to a fusion protein of MOX identifies a single band of the expected mobility by Western blot analysis [6].
  • A single 1.0 gm ip dose leads to serum and dialysate MOX concentrations above the minimum inhibitory concentration for susceptible pathogens for 24 hours [10].
  • Immediately after bilateral en bloc nephrectomy, kidneys were placed on the Waters MOX pulsatile preservation machine [11].

References

  1. Effects of moxonidine vs. metoprolol on blood pressure and metabolic control in hypertensive subjects with type 2 diabetes. Jacob, S., Klimm, H.J., Rett, K., Helsberg, K., Häring, H.U., Gödicke, J. Exp. Clin. Endocrinol. Diabetes (2004) [Pubmed]
  2. Fourth generation fluoroquinolones: new weapons in the arsenal of ophthalmic antibiotics. Mather, R., Karenchak, L.M., Romanowski, E.G., Kowalski, R.P. Am. J. Ophthalmol. (2002) [Pubmed]
  3. Monooxygenase X, a member of the copper-dependent monooxygenase family localized to the endoplasmic reticulum. Xin, X., Mains, R.E., Eipper, B.A. J. Biol. Chem. (2004) [Pubmed]
  4. A histone deacetylase inhibitor potentiates estrogen receptor activation of a stably integrated vitellogenin promoter in HepG2 cells. Mao, C., Shapiro, D.J. Endocrinology (2000) [Pubmed]
  5. Agonist enhacement of macrocyclic lactone activity at a glutamate-gated chloride channel subunit from Haemonchus contortus. Forrester, S.G., Beech, R.N., Prichard, R.K. Biochem. Pharmacol. (2004) [Pubmed]
  6. Identification and cloning of a sequence homologue of dopamine beta-hydroxylase. Chambers, K.J., Tonkin, L.A., Chang, E., Shelton, D.N., Linskens, M.H., Funk, W.D. Gene (1998) [Pubmed]
  7. Increased yields of pathogenic Yersinia enterocolitica strains by cold enrichment. Kontiainen, S., Sivonen, A., Renkonen, O.V. Scand. J. Infect. Dis. (1994) [Pubmed]
  8. Modern new nuclear fuel characteristics and radiation protection aspects. Terry, I.R. Radiation protection dosimetry. (2005) [Pubmed]
  9. Strain and process development for the production of human cytokines in Hansenula polymorpha. Degelmann, A., Müller, F., Sieber, H., Jenzelewski, V., Suckow, M., Strasser, A.W., Gellissen, G. FEMS Yeast Res. (2002) [Pubmed]
  10. Moxalactam epimer disposition in patients undergoing continuous ambulatory peritoneal dialysis. Morse, G., Janicke, D., Cafarell, R., Piontek, K., Apicella, M., Jusko, W.J., Walshe, J. Clin. Pharmacol. Ther. (1985) [Pubmed]
  11. Long-term graft survival after transplantation with kidneys from uncontrolled nonheartbeating donors. Light, J.A., Barhyte, D.Y., Gage, F.A., Sasaki, T.M., Aquino, A.O. Transplantation (1999) [Pubmed]
 
WikiGenes - Universities