Chemical Compound Review:
Bioxiran 2-(oxiran-2-yl)oxirane
Synonyms:
Bioxirane, Diepoxybutane, Butadiendioxyd, Dioxybutadiene, NSC-629, ...
- Localisation of the Fanconi anaemia complementation group A gene to chromosome 16q24.3. Pronk, J.C., Gibson, R.A., Savoia, A., Wijker, M., Morgan, N.V., Melchionda, S., Ford, D., Temtamy, S., Ortega, J.J., Jansen, S. Nat. Genet. (1995)
- Inactivation of Fac in mice produces inducible chromosomal instability and reduced fertility reminiscent of Fanconi anaemia. Chen, M., Tomkins, D.J., Auerbach, W., McKerlie, C., Youssoufian, H., Liu, L., Gan, O., Carreau, M., Auerbach, A., Groves, T., Guidos, C.J., Freedman, M.H., Cross, J., Percy, D.H., Dick, J.E., Joyner, A.L., Buchwald, M. Nat. Genet. (1996)
- Transfection of normal human and Chinese hamster DNA corrects diepoxybutane-induced chromosomal hypersensitivity of Fanconi anemia fibroblasts. Shaham, M., Adler, B., Ganguly, S., Chaganti, R.S. Proc. Natl. Acad. Sci. U.S.A. (1987)
- Acquired FANCA dysfunction and cytogenetic instability in adult acute myelogenous leukemia. Lensch, M.W., Tischkowitz, M., Christianson, T.A., Reifsteck, C.A., Speckhart, S.A., Jakobs, P.M., O'Dwyer, M.E., Olson, S.B., Le Beau, M.M., Hodgson, S.V., Mathew, C.G., Larson, R.A., Bagby, G.C. Blood (2003)
- Susceptibility to induction of chromosomal damage by metabolites of 1,3-butadiene and its relationship to 'spontaneous' sister chromatid exchange frequencies in human lymphocytes. Wiencke, J.K., Kelsey, K.T. IARC Sci. Publ. (1993)
- Expression cloning of a cDNA for the major Fanconi anaemia gene, FAA. Lo Ten Foe, J.R., Rooimans, M.A., Bosnoyan-Collins, L., Alon, N., Wijker, M., Parker, L., Lightfoot, J., Carreau, M., Callen, D.F., Savoia, A., Cheng, N.C., van Berkel, C.G., Strunk, M.H., Gille, J.J., Pals, G., Kruyt, F.A., Pronk, J.C., Arwert, F., Buchwald, M., Joenje, H. Nat. Genet. (1996)
- Identification by RNA-protein cross-linking of ribosomal proteins located at the interface between the small and the large subunits of mammalian ribosomes. Nygård, O., Nika, H. EMBO J. (1982)
- Carcinogens induce genome-wide loss of heterozygosity in normal stem cells without persistent chromosomal instability. Donahue, S.L., Lin, Q., Cao, S., Ruley, H.E. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Preliminary communication: prenatal detection of the Fanconi Anemia gene by cytogenetic methods. Auerbach, A.D., Warburton, D., Bloom, A.D., Chaganti, R.S. Am. J. Hum. Genet. (1979)
- Bone marrow failure in the Fanconi anemia group C mouse model after DNA damage. Carreau, M., Gan, O.I., Liu, L., Doedens, M., McKerlie, C., Dick, J.E., Buchwald, M. Blood (1998)
- Human glutathione S-transferase T1-1 enhances mutagenicity of 1,2-dibromoethane, dibromomethane and 1,2,3,4-diepoxybutane in Salmonella typhimurium. Thier, R., Pemble, S.E., Kramer, H., Taylor, J.B., Guengerich, F.P., Ketterer, B. Carcinogenesis (1996)
- In vitro and in vivo genotoxicity of 1,3-butadiene and metabolites. Arce, G.T., Vincent, D.R., Cunningham, M.J., Choy, W.N., Sarrif, A.M. Environ. Health Perspect. (1990)
- Enhancement of chromosomal damage by arsenic: implications for mechanism. Yager, J.W., Wiencke, J.K. Environ. Health Perspect. (1993)
- In vitro and in vivo mutagenicity of the butadiene metabolites butadiene diolepoxide, butadiene monoepoxide and diepoxybutane. Adler, I.D., Kliesch, U., Nylund, L., Peltonen, K. Mutagenesis (1997)
- A novel diagnostic screen for defects in the Fanconi anemia pathway. Shimamura, A., de Oca, R.M., Svenson, J.L., Haining, N., Moreau, L.A., Nathan, D.G., D'Andrea, A.D. Blood (2002)
- International Fanconi Anemia Registry: relation of clinical symptoms to diepoxybutane sensitivity. Auerbach, A.D., Rogatko, A., Schroeder-Kurth, T.M. Blood (1989)
- Comparative evaluation of diepoxybutane sensitivity and cell cycle blockage in the diagnosis of Fanconi anemia. Seyschab, H., Friedl, R., Sun, Y., Schindler, D., Hoehn, H., Hentze, S., Schroeder-Kurth, T. Blood (1995)
- Individual susceptibility to induced chromosome damage and its implications for detecting genotoxic exposures in human populations. Wiencke, J.K., Wrensch, M.R., Miike, R., Petrakis, N.L. Cancer Res. (1991)
- Defective DNA cross-link removal in Chinese hamster cell mutants hypersensitive to bifunctional alkylating agents. Hoy, C.A., Thompson, L.H., Mooney, C.L., Salazar, E.P. Cancer Res. (1985)
- Mutagenicity of butadiene and its epoxide metabolites: II. Mutational spectra of butadiene, 1,2-epoxybutene and diepoxybutane at the hprt locus in splenic T cells from exposed B6C3F1 mice. Cochrane, J.E., Skopek, T.R. Carcinogenesis (1994)
- Comparison of the biotransformation of 1,3-butadiene and its metabolite, butadiene monoepoxide, by hepatic and pulmonary tissues from humans, rats and mice. Csanády, G.A., Guengerich, F.P., Bond, J.A. Carcinogenesis (1992)
- Adenine adducts with diepoxybutane: isolation and analysis in exposed calf thymus DNA. Tretyakova, N., Sangaiah, R., Yen, T.Y., Gold, A., Swenberg, J.A. Chem. Res. Toxicol. (1997)
- Fanconi anemia: prenatal diagnosis in 30 fetuses at risk. Auerbach, A.D., Sagi, M., Adler, B. Pediatrics (1985)
- Dyskeratosis congenita fibroblasts are abnormal and have unbalanced chromosomal rearrangements. Dokal, I., Bungey, J., Williamson, P., Oscier, D., Hows, J., Luzzatto, L. Blood (1992)
- Role of GSTT1 and GSTM1 genotypes in determining individual sensitivity to sister chromatid exchange induction by diepoxybutane in cultured human lymphocytes. Norppa, H., Hirvonen, A., Järventaus, H., Uusküla, M., Tasa, G., Ojajärvi, A., Sorsa, M. Carcinogenesis (1995)
- Differential response of familial polyposis fibroblasts to two bifunctional alkylating agents. Friedman, E., Carnright, K., Lipkin, M. Carcinogenesis (1982)
- Diepoxybutane and diepoxyoctane interstrand cross-linking of the 5S DNA nucleosomal core particle. Millard, J.T., Wilkes, E.E. Biochemistry (2001)
- Cytogenetic studies in lymphocytes of patients with rectal cancer. Gebhart, E., Romahn, R., Schneider, A., Hoffmann, M., Rau, D., Tittelbach, H. Environ. Health Perspect. (1993)
- Influence of GSTT1, mEH, CYP2E1 and RAD51 polymorphisms on diepoxybutane-induced SCE frequency in cultured human lymphocytes. Schlade-Bartusiak, K., Rozik, K., Laczmanska, I., Ramsey, D., Sasiadek, M. Mutat. Res. (2004)
- Elevated levels of recombinational DNA repair in human somatic cells expressing the Saccharomyces cerevisiae RAD52 gene. Johnson, B.L., Thyagarajan, B., Krueger, L., Hirsch, B., Campbell, C. Mutat. Res. (1996)
- Mitomycin C and diepoxybutane action mechanisms and FANCC protein functions: further insights into the role for oxidative stress in Fanconi's anaemia phenotype. Pagano, G. Carcinogenesis (2000)
- Induction of sister chromatid exchange by 3,4-expoxybutane-1,2-diol in cultured human lymphocytes of different GSTT1 and GSTM1 genotypes. Bernardini, S., Pelin, K., Peltonen, K., Järventaus, H., Hirvonen, A., Neagu, C., Sorsa, M., Norppa, H. Mutat. Res. (1996)
- Proliferation-associated expression of the MEN1 gene as revealed by in situ hybridization: possible role of the menin as a negative regulator of cell proliferation under DNA damage. Ikeo, Y., Sakurai, A., Suzuki, R., Zhang, M.X., Koizumi, S., Takeuchi, Y., Yumita, W., Nakayama, J., Hashizume, K. Lab. Invest. (2000)
- Cross-linked amino acids in the protein pairs L3-L19 and L23-L29 of Bacillus stearothermophilus ribosomes after treatment with diepoxybutane. Herwig, S., Kruft, V., Eckart, K., Wittmann-Liebold, B. J. Biol. Chem. (1993)
- Genotoxic markers among butadiene polymer workers in China. Hayes, R.B., Zhang, L., Yin, S., Swenberg, J.A., Xi, L., Wiencke, J., Bechtold, W.E., Yao, M., Rothman, N., Haas, R., O'Neill, J.P., Zhang, D., Wiemels, J., Dosemeci, M., Li, G., Smith, M.T. Carcinogenesis (2000)
- Persistence of N7-(2,3,4-trihydroxybutyl)guanine adducts in the livers of mice and rats exposed to 1,3-butadiene. Oe, T., Kambouris, S.J., Walker, V.E., Meng, Q., Recio, L., Wherli, S., Chaudhary, A.K., Blair, I.A. Chem. Res. Toxicol. (1999)
- Analysis of butadiene, butadiene monoxide, and butadiene dioxide in blood by gas chromatography/gas chromatography/mass spectroscopy. Bechtold, W.E., Strunk, M.R., Thornton-Manning, J.R., Henderson, R.F. Chem. Res. Toxicol. (1995)
- Induction of unusual tumors in vivo by rat fibroblasts treated with diepoxybutane. Wolman, S.R., Sivak, A. Lab. Invest. (1975)