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Gene Review

Omp  -  olfactory marker protein

Mus musculus

Synonyms: Olfactory marker protein
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Disease relevance of Omp

  • This is evident from the behavioral and electrophysiological deficits of OMP-null mice, which can be reversed by intranasal infection of olfactory sensory neurons with an OMP-expressing adenovirus [1].
  • A hybrid oncogene was constructed utilizing the regulatory elements for the olfactory marker protein gene to direct the olfactory neuronal-specific expression of simian virus 40 T-antigen, a potent oncogene [2].
  • While OMP has no significant sequence homology to proteins of known structure, it has a similar fold to a domain found in a variety of existing structures, including in a large family of viral capsid proteins [3].
  • This monoclonal antibody reacted specifically with Omp29 of A. actinomycetemcomitans (serotype b), but not with any Omp of Escherichia coli, including OmpA [4].
  • The gene encoding an outer membrane protein A (OmpA)-like, heat-modifiable Omp of Actinobacillus actinomycetemcomitans ATCC 43718 (strain Y4, serotype b) was cloned by a PCR cloning procedure [4].

High impact information on Omp

  • This adenoviral-mediated rescue of the OMP-null phenotype is consistent with involvement of OMP in olfactory transduction [5].
  • Adenoviral vector-mediated rescue of the OMP-null phenotype in vivo [5].
  • LIF-deficient mice display significant increases, both in the absolute amount and in the number of cells expressing olfactory marker protein, a marker of mature ORNs [6].
  • The murine homologue of OMP is tightly linked to the autosomal recessive deafness gene sh-1 [7].
  • Increased cell death in combination with increased expression of the early differentiation marker Neurod1, as well as reduced expression of late differentiation markers (Galphaolf and Omp), suggests that neuronal differentiation in the absence of Lhx2 is primarily inhibited at, or immediate prior to, onset of OR expression [8].

Biological context of Omp

  • Haplotype analysis indicates that Omp lies proximal to sh-1 [9].
  • The molecular basis for the altered phenotype following the deletion of OMP is still unclear [10].
  • The OMP/Bex interaction has been confirmed by demonstrating the chemical cross-linking of recombinant rat OMP with a synthetic peptide derived from the Bex amino acid sequence [10].
  • Here we report the identification of an OMP partner, Bex2, by phage-display screening of an olfactory mucosal cDNA-library [10].
  • However, in contrast to the adult, where its expression is restricted to the medial sensory neuronal component of the VNO, during fetal development OMP is also present in cells located in the lateral non-sensory epithelial component [11].

Anatomical context of Omp


Associations of Omp with chemical compounds

  • This behavior of carnosine is consistent with that reported for the olfactory marker protein (OMP) [15].
  • Formation of a full complement of OMP-expressing neurons occurs only after peripheral lesion with TX-100 [16].
  • Following treatment with either ZnSO4 or Triton X-100, the pattern of changes in steady-state levels of OMP mRNA was similar to that observed for TH [17].
  • The first [3H]thymidine-labeled, OMP-containing elements have been observed 7 days after administration of the radioactive thymidine [18].
  • The neurons were judged to be intact and viable by trypan blue dye exclusion, the presence of olfactory marker protein (OMP), and a variety of electrophysiological measurements indicating the presence of substantial membrane potentials, low levels of intracellular Ca2+, and the ability to fire action potentials [19].

Regulatory relationships of Omp


Other interactions of Omp


Analytical, diagnostic and therapeutic context of Omp


  1. The interaction of Bex and OMP reveals a dimer of OMP with a short half-life. Koo, J.H., Gill, S., Pannell, L.K., Menco, B.P., Margolis, J.W., Margolis, F.L. J. Neurochem. (2004) [Pubmed]
  2. Directed expression of an oncogene to the olfactory neuronal lineage in transgenic mice. Largent, B.L., Sosnowski, R.G., Reed, R.R. J. Neurosci. (1993) [Pubmed]
  3. The crystal structure of the olfactory marker protein at 2.3 A resolution. Smith, P.C., Firestein, S., Hunt, J.F. J. Mol. Biol. (2002) [Pubmed]
  4. Cloning of the gene encoding the Actinobacillus actinomycetemcomitans serotype b OmpA-like outer membrane protein. Komatsuzawa, H., Kawai, T., Wilson, M.E., Taubman, M.A., Sugai, M., Suginaka, H. Infect. Immun. (1999) [Pubmed]
  5. Adenoviral vector-mediated rescue of the OMP-null phenotype in vivo. Ivic, L., Pyrski, M.M., Margolis, J.W., Richards, L.J., Firestein, S., Margolis, F.L. Nat. Neurosci. (2000) [Pubmed]
  6. Leukemia inhibitory factor inhibits neuronal terminal differentiation through STAT3 activation. Moon, C., Yoo, J.Y., Matarazzo, V., Sung, Y.K., Kim, E.J., Ronnett, G.V. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  7. A human gene responsible for neurosensory, non-syndromic recessive deafness is a candidate homologue of the mouse sh-1 gene. Guilford, P., Ayadi, H., Blanchard, S., Chaib, H., Le Paslier, D., Weissenbach, J., Drira, M., Petit, C. Hum. Mol. Genet. (1994) [Pubmed]
  8. The Lim homeobox gene Lhx2 is required for olfactory sensory neuron identity. Kolterud, A., Alenius, M., Carlsson, L., Bohm, S. Development (2004) [Pubmed]
  9. Close linkage of the olfactory marker protein gene to the mouse deafness mutation shaker-1. Brown, K.A., Sutcliffe, M.J., Steel, K.P., Brown, S.D. Genomics (1992) [Pubmed]
  10. Identification of members of the Bex gene family as olfactory marker protein (OMP) binding partners. Behrens, M., Margolis, J.W., Margolis, F.L. J. Neurochem. (2003) [Pubmed]
  11. Prenatal differentiation of mouse vomeronasal neurones. Tarozzo, G., Cappello, P., De Andrea, M., Walters, E., Margolis, F.L., Oestreicher, B., Fasolo, A. Eur. J. Neurosci. (1998) [Pubmed]
  12. Immunolocalization of Bex protein in the mouse brain and olfactory system. Koo, J.H., Saraswati, M., Margolis, F.L. J. Comp. Neurol. (2005) [Pubmed]
  13. Naris occlusion alters olfactory marker protein immunoreactivity in olfactory epithelium. Waguespack, A.M., Reems, M.R., Butman, M.L., Cherry, J.A., Coppola, D.M. Brain Res. (2005) [Pubmed]
  14. Delayed olfactory nerve regeneration in ApoE-deficient mice. Nathan, B.P., Nisar, R., Short, J., Randall, S., Grissom, E., Griffin, G., Switzer, P.V., Struble, R.G. Brain Res. (2005) [Pubmed]
  15. Alteration of carnosine expression in olfactory system of mouse after unilateral naris closure and partial bulbectomy. Sakai, M., Nagatsu, I. J. Neurosci. Res. (1993) [Pubmed]
  16. Neuroplasticity in the olfactory system: differential effects of central and peripheral lesions of the primary olfactory pathway on the expression of B-50/GAP43 and the olfactory marker protein. Verhaagen, J., Oestreicher, A.B., Grillo, M., Khew-Goodall, Y.S., Gispen, W.H., Margolis, F.L. J. Neurosci. Res. (1990) [Pubmed]
  17. Transneuronal regulation of neuronal specific gene expression in the mouse olfactory bulb. Ehrlich, M.E., Grillo, M., Joh, T.H., Margolis, F.L., Baker, H. Brain Res. Mol. Brain Res. (1990) [Pubmed]
  18. Experimental studies on the olfactory marker protein. II. Appearance of the olfactory marker protein during differentiation of the olfactory sensory neurons of mouse: an immunohistochemical and autoradiographic study. Miragall, F., Monti Graziadei, G.A. Brain Res. (1982) [Pubmed]
  19. Preparation of isolated mouse olfactory receptor neurons. Maue, R.A., Dionne, V.E. Pflugers Arch. (1987) [Pubmed]
  20. Olfactory marker protein modulates primary olfactory axon overshooting in the olfactory bulb. St John, J.A., Key, B. J. Comp. Neurol. (2005) [Pubmed]
  21. ErbB-4 and neuregulin expression in the adult mouse olfactory bulb after peripheral denervation. Oberto, M., Soncin, I., Bovolin, P., Voyron, S., De Bortoli, M., Dati, C., Fasolo, A., Perroteau, I. Eur. J. Neurosci. (2001) [Pubmed]
  22. Sublaminar organization of the mouse olfactory bulb nerve layer. Au, W.W., Treloar, H.B., Greer, C.A. J. Comp. Neurol. (2002) [Pubmed]
  23. Targeted deletion of a cyclic nucleotide-gated channel subunit (OCNC1): biochemical and morphological consequences in adult mice. Baker, H., Cummings, D.M., Munger, S.D., Margolis, J.W., Franzen, L., Reed, R.R., Margolis, F.L. J. Neurosci. (1999) [Pubmed]
  24. Unusual regulation of cyclin D1 and cyclin-dependent kinases cdk2 and cdk4 during in vivo mitotic stimulation of olfactory neuron progenitors in adult mouse. Kastner, A., Moyse, E., Bauer, S., Jourdan, F., Brun, G. J. Neurochem. (2000) [Pubmed]
  25. Deletion mapping of four loci defined by N-ethyl-N-nitrosourea-induced postimplantation-lethal mutations within the pid-Hbb region of mouse chromosome 7. Rinchik, E.M., Carpenter, D.A., Long, C.L. Genetics (1993) [Pubmed]
  26. Lectin-induced apoptosis of mature olfactory receptor cells. Moon, Y.W., Baker, H. J. Neurosci. Res. (2002) [Pubmed]
  27. Odorant receptor expression as a function of neuronal maturity in the adult rodent olfactory system. Iwema, C.L., Schwob, J.E. J. Comp. Neurol. (2003) [Pubmed]
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