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NIN  -  ninein (GSK3B interacting protein)

Homo sapiens

Synonyms: GSK3B-interacting protein, Glycogen synthase kinase 3 beta-interacting protein, KIAA1565, Ninein, hNinein
 
 
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Disease relevance of NIN

 

High impact information on NIN

  • NIN protein has regional similarity to transcription factors, and the predicted DNA-binding/dimerization domain identifies and typifies a consensus motif conserved in plant proteins with a function in nitrogen-controlled development [4].
  • Loss of microtubule organization was also observed after centrin or ninein depletion [5].
  • After treatment with imatinib, the patient achieved hematological and cytogenetical remission, but NIN-PDGFRB mRNA remained detectable by reverse transcription-PCR [6].
  • During centriole duplication, Nudel targets to the new mother centriole later than ninein but earlier than dynactin [7].
  • We found that the centrosomal component ninein, first identified in mice, has a human homolog that is an autoantigen [8].
 

Biological context of NIN

 

Anatomical context of NIN

 

Associations of NIN with chemical compounds

  • Construction of serial deletions of GFP-tagged ninein reveals that a stretch of three leucine zippers with a flanking sequence is required and sufficient for centrosomal targeting [13].
  • The bisporphyrin host ZnH was synthesized, and its complexation with two aromatic diimide guest molecules, bis(pyridyl)naphthalenediimide NIN and bis(pyridyl)phenyldiimide PIN, was investigated by (1)H NMR and UV/Vis spectroscopy [14].
  • METHODS: Streptozocin (STZ; 55 mg/kg body mass) induced diabetic male Wistar/NIN rats (2-3 months old) and control nondiabetic rats were used for this study [15].
 

Other interactions of NIN

 

Analytical, diagnostic and therapeutic context of NIN

References

  1. A novel ninein-interaction protein, CGI-99, blocks ninein phosphorylation by GSK3beta and is highly expressed in brain tumors. Howng, S.L., Hsu, H.C., Cheng, T.S., Lee, Y.L., Chang, L.K., Lu, P.J., Hong, Y.R. FEBS Lett. (2004) [Pubmed]
  2. Comparative analysis of expression profiling of early-stage carcinogenesis using nodule-in-nodule-type hepatocellular carcinoma. Nam, S.W., Lee, J.H., Noh, J.H., Lee, S.N., Kim, S.Y., Lee, S.H., Park, C.K., Ahn, Y.M., Park, W.S., Yoo, N.J., Lee, J.Y. European journal of gastroenterology & hepatology. (2006) [Pubmed]
  3. Hypermethylation of Chfr and hMLH1 in gastric noninvasive and early invasive neoplasias. Homma, N., Tamura, G., Honda, T., Jin, Z., Ohmura, K., Kawata, S., Motoyama, T. Virchows Arch. (2005) [Pubmed]
  4. A plant regulator controlling development of symbiotic root nodules. Schauser, L., Roussis, A., Stiller, J., Stougaard, J. Nature (1999) [Pubmed]
  5. Assembly of centrosomal proteins and microtubule organization depends on PCM-1. Dammermann, A., Merdes, A. J. Cell Biol. (2002) [Pubmed]
  6. NIN, a gene encoding a CEP110-like centrosomal protein, is fused to PDGFRB in a patient with a t(5;14)(q33;q24) and an imatinib-responsive myeloproliferative disorder. Vizmanos, J.L., Novo, F.J., Román, J.P., Baxter, E.J., Lahortiga, I., Larráyoz, M.J., Odero, M.D., Giraldo, P., Calasanz, M.J., Cross, N.C. Cancer Res. (2004) [Pubmed]
  7. Nudel contributes to microtubule anchoring at the mother centriole and is involved in both dynein-dependent and -independent centrosomal protein assembly. Guo, J., Yang, Z., Song, W., Chen, Q., Wang, F., Zhang, Q., Zhu, X. Mol. Biol. Cell (2006) [Pubmed]
  8. Autoantibodies to a group of centrosomal proteins in human autoimmune sera reactive with the centrosome. Mack, G.J., Rees, J., Sandblom, O., Balczon, R., Fritzler, M.J., Rattner, J.B. Arthritis Rheum. (1998) [Pubmed]
  9. Phosphorylation of Nlp by Plk1 negatively regulates its dynein-dynactin-dependent targeting to the centrosome. Casenghi, M., Barr, F.A., Nigg, E.A. J. Cell. Sci. (2005) [Pubmed]
  10. SUMO-1 modification of centrosomal protein hNinein promotes hNinein nuclear localization. Cheng, T.S., Chang, L.K., Howng, S.L., Lu, P.J., Lee, C.I., Hong, Y.R. Life Sci. (2006) [Pubmed]
  11. CEP110 and ninein are located in a specific domain of the centrosome associated with centrosome maturation. Ou, Y.Y., Mack, G.J., Zhang, M., Rattner, J.B. J. Cell. Sci. (2002) [Pubmed]
  12. Genomic organization and molecular characterization of the human ninein gene. Hong, Y.R., Chen, C.H., Chuo, M.H., Liou, S.Y., Howng, S.L. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  13. Human ninein is a centrosomal autoantigen recognized by CREST patient sera and plays a regulatory role in microtubule nucleation. Stillwell, E.E., Zhou, J., Joshi, H.C. Cell Cycle (2004) [Pubmed]
  14. Photoinduced electron transfer in bisporphyrin-diimide complexes. Flamigni, L., Johnston, M.R., Giribabu, L. Chemistry (Weinheim an der Bergstrasse, Germany) (2002) [Pubmed]
  15. Immunochemical detection of glycated beta- and gamma-crystallins in lens and their circulating autoantibodies (IgG) in streptozocin induced diabetic rat. Ranjan, M., Nayak, S., Rao, B.S. Mol. Vis. (2006) [Pubmed]
  16. Pancreatic islet transplantation: utility of ductular obstruction and exocrine atrophy model? Verma, A., Dinda, A., Sarkar, C., Fotedar, R., Dhawan, I.K., Sharma, L.K., Khetarpal, K., Fotedar, A., Srikanta, S., Kochupillai, N. Tropical gastroenterology : official journal of the Digestive Diseases Foundation. (1990) [Pubmed]
 
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