The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

NIN  -  ninein (GSK3B interacting protein)

Homo sapiens

Synonyms: GSK3B-interacting protein, Glycogen synthase kinase 3 beta-interacting protein, KIAA1565, Ninein, hNinein
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of NIN


High impact information on NIN

  • NIN protein has regional similarity to transcription factors, and the predicted DNA-binding/dimerization domain identifies and typifies a consensus motif conserved in plant proteins with a function in nitrogen-controlled development [4].
  • Loss of microtubule organization was also observed after centrin or ninein depletion [5].
  • After treatment with imatinib, the patient achieved hematological and cytogenetical remission, but NIN-PDGFRB mRNA remained detectable by reverse transcription-PCR [6].
  • During centriole duplication, Nudel targets to the new mother centriole later than ninein but earlier than dynactin [7].
  • We found that the centrosomal component ninein, first identified in mice, has a human homolog that is an autoantigen [8].

Biological context of NIN


Anatomical context of NIN


Associations of NIN with chemical compounds

  • Construction of serial deletions of GFP-tagged ninein reveals that a stretch of three leucine zippers with a flanking sequence is required and sufficient for centrosomal targeting [13].
  • The bisporphyrin host ZnH was synthesized, and its complexation with two aromatic diimide guest molecules, bis(pyridyl)naphthalenediimide NIN and bis(pyridyl)phenyldiimide PIN, was investigated by (1)H NMR and UV/Vis spectroscopy [14].
  • METHODS: Streptozocin (STZ; 55 mg/kg body mass) induced diabetic male Wistar/NIN rats (2-3 months old) and control nondiabetic rats were used for this study [15].

Other interactions of NIN


Analytical, diagnostic and therapeutic context of NIN


  1. A novel ninein-interaction protein, CGI-99, blocks ninein phosphorylation by GSK3beta and is highly expressed in brain tumors. Howng, S.L., Hsu, H.C., Cheng, T.S., Lee, Y.L., Chang, L.K., Lu, P.J., Hong, Y.R. FEBS Lett. (2004) [Pubmed]
  2. Comparative analysis of expression profiling of early-stage carcinogenesis using nodule-in-nodule-type hepatocellular carcinoma. Nam, S.W., Lee, J.H., Noh, J.H., Lee, S.N., Kim, S.Y., Lee, S.H., Park, C.K., Ahn, Y.M., Park, W.S., Yoo, N.J., Lee, J.Y. European journal of gastroenterology & hepatology. (2006) [Pubmed]
  3. Hypermethylation of Chfr and hMLH1 in gastric noninvasive and early invasive neoplasias. Homma, N., Tamura, G., Honda, T., Jin, Z., Ohmura, K., Kawata, S., Motoyama, T. Virchows Arch. (2005) [Pubmed]
  4. A plant regulator controlling development of symbiotic root nodules. Schauser, L., Roussis, A., Stiller, J., Stougaard, J. Nature (1999) [Pubmed]
  5. Assembly of centrosomal proteins and microtubule organization depends on PCM-1. Dammermann, A., Merdes, A. J. Cell Biol. (2002) [Pubmed]
  6. NIN, a gene encoding a CEP110-like centrosomal protein, is fused to PDGFRB in a patient with a t(5;14)(q33;q24) and an imatinib-responsive myeloproliferative disorder. Vizmanos, J.L., Novo, F.J., Román, J.P., Baxter, E.J., Lahortiga, I., Larráyoz, M.J., Odero, M.D., Giraldo, P., Calasanz, M.J., Cross, N.C. Cancer Res. (2004) [Pubmed]
  7. Nudel contributes to microtubule anchoring at the mother centriole and is involved in both dynein-dependent and -independent centrosomal protein assembly. Guo, J., Yang, Z., Song, W., Chen, Q., Wang, F., Zhang, Q., Zhu, X. Mol. Biol. Cell (2006) [Pubmed]
  8. Autoantibodies to a group of centrosomal proteins in human autoimmune sera reactive with the centrosome. Mack, G.J., Rees, J., Sandblom, O., Balczon, R., Fritzler, M.J., Rattner, J.B. Arthritis Rheum. (1998) [Pubmed]
  9. Phosphorylation of Nlp by Plk1 negatively regulates its dynein-dynactin-dependent targeting to the centrosome. Casenghi, M., Barr, F.A., Nigg, E.A. J. Cell. Sci. (2005) [Pubmed]
  10. SUMO-1 modification of centrosomal protein hNinein promotes hNinein nuclear localization. Cheng, T.S., Chang, L.K., Howng, S.L., Lu, P.J., Lee, C.I., Hong, Y.R. Life Sci. (2006) [Pubmed]
  11. CEP110 and ninein are located in a specific domain of the centrosome associated with centrosome maturation. Ou, Y.Y., Mack, G.J., Zhang, M., Rattner, J.B. J. Cell. Sci. (2002) [Pubmed]
  12. Genomic organization and molecular characterization of the human ninein gene. Hong, Y.R., Chen, C.H., Chuo, M.H., Liou, S.Y., Howng, S.L. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  13. Human ninein is a centrosomal autoantigen recognized by CREST patient sera and plays a regulatory role in microtubule nucleation. Stillwell, E.E., Zhou, J., Joshi, H.C. Cell Cycle (2004) [Pubmed]
  14. Photoinduced electron transfer in bisporphyrin-diimide complexes. Flamigni, L., Johnston, M.R., Giribabu, L. Chemistry (Weinheim an der Bergstrasse, Germany) (2002) [Pubmed]
  15. Immunochemical detection of glycated beta- and gamma-crystallins in lens and their circulating autoantibodies (IgG) in streptozocin induced diabetic rat. Ranjan, M., Nayak, S., Rao, B.S. Mol. Vis. (2006) [Pubmed]
  16. Pancreatic islet transplantation: utility of ductular obstruction and exocrine atrophy model? Verma, A., Dinda, A., Sarkar, C., Fotedar, R., Dhawan, I.K., Sharma, L.K., Khetarpal, K., Fotedar, A., Srikanta, S., Kochupillai, N. Tropical gastroenterology : official journal of the Digestive Diseases Foundation. (1990) [Pubmed]
WikiGenes - Universities