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dnt  -  dermonecrotic toxin

Bordetella pertussis Tohama I



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Disease relevance of dnt


High impact information on dnt


Chemical compound and disease context of dnt


Biological context of dnt

  • Pharmacological analyses with various reagents disturbing vesicular trafficking revealed that the translocation requires neither the acidification of the endosomes nor retrograde vesicular transport to deeper organelles, although DNT appeared to be internalized via a dynamin-dependent endocytosis [2].
  • Intranasal inoculation of the spontaneous phase variants into 3-day-old turkeys and reisolation of B. avium at 2 weeks postinoculation resulted in the recovery of B. avium which had the wild-type phenotype, colonized the turkey tracheas, and produced the four outer membrane proteins and dermonecrotic toxin [7].
  • Comparative genomic hybridization analysis identified the absence of the pertussis toxin locus and dermonecrotic toxin gene, as well as a polymorphic lipopolysaccharide biosynthesis locus, as associated with adaptation of complex IV strains to the human host [8].

Anatomical context of dnt


Associations of dnt with chemical compounds

  • Two mutants were deficient in the production of the filamentous hemagglutinin, two mutants were deficient in the production of adenylate cyclase toxin and hemolysin, and one mutant was deficient in the production of dermonecrotic toxin [11].
  • When injected intraperitoneally into rats, a dose of 0.13 mg of LPF per kg elevated the cyclic GMP level in cerebellum by approximately 70%, whereas DNT (0.5 mg/kg) and LPS (1.5 mg/kg) were without effect [5].


  1. Phase variation in Bordetella pertussis by frameshift mutation in a gene for a novel two-component system. Stibitz, S., Aaronson, W., Monack, D., Falkow, S. Nature (1989) [Pubmed]
  2. Bordetella dermonecrotic toxin undergoes proteolytic processing to be translocated from a dynamin-related endosome into the cytoplasm in an acidification-independent manner. Matsuzawa, T., Fukui, A., Kashimoto, T., Nagao, K., Oka, K., Miyake, M., Horiguchi, Y. J. Biol. Chem. (2004) [Pubmed]
  3. Characterization of the dermonecrotic toxin in members of the genus Bordetella. Walker, K.E., Weiss, A.A. Infect. Immun. (1994) [Pubmed]
  4. Characterization of murine lung inflammation after infection with parental Bordetella pertussis and mutants deficient in adhesins or toxins. Khelef, N., Bachelet, C.M., Vargaftig, B.B., Guiso, N. Infect. Immun. (1994) [Pubmed]
  5. Effect of lymphocytosis-promoting factor from Bordetella pertussis on cerebellar cyclic GMP levels. Askelöf, P., Gillenius, P. Infect. Immun. (1982) [Pubmed]
  6. Dermonecrotic toxin and tracheal cytotoxin, putative virulence factors of Bordetella avium. Gentry-Weeks, C.R., Cookson, B.T., Goldman, W.E., Rimler, R.B., Porter, S.B., Curtiss, R. Infect. Immun. (1988) [Pubmed]
  7. Isolation and characterization of Bordetella avium phase variants. Gentry-Weeks, C.R., Provence, D.L., Keith, J.M., Curtiss, R. Infect. Immun. (1991) [Pubmed]
  8. Bordetella pertussis, the Causative Agent of Whooping Cough, Evolved from a Distinct, Human-Associated Lineage of B. bronchiseptica. Diavatopoulos, D.A., Cummings, C.A., Schouls, L.M., Brinig, M.M., Relman, D.A., Mooi, F.R. PLoS Pathog. (2005) [Pubmed]
  9. Bordetella pertussis virulence factors affect phagocytosis by human neutrophils. Weingart, C.L., Weiss, A.A. Infect. Immun. (2000) [Pubmed]
  10. Bordetella pertussis tracheal cytotoxin. Goldman, W.E., Herwaldt, L.A. Dev. Biol. Stand. (1985) [Pubmed]
  11. Use of the promoter fusion transposon Tn5 lac to identify mutations in Bordetella pertussis vir-regulated genes. Weiss, A.A., Melton, A.R., Walker, K.E., Andraos-Selim, C., Meidl, J.J. Infect. Immun. (1989) [Pubmed]
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