Disease relevance of isoxsuprine

• Increased red blood cell deformability due to isoxsuprine administration decreases platelet adherence in a perfusion chamber: a double-blind cross-over study in patients with intermittent claudication [1].
• A retrospective study of all inborn infants at 26 to 35 weeks' gestational age delivered from August, 1976, through July, 1977, was undertaken to determine the effects on the neonate of maternal isoxsuprine therapy for premature labor [2].
• Follow-up of infants of less than 1500 gm birth weight with antenatal isoxsuprine exposure [3].
• Pulmonary edema associated with isoxsuprine therapy [4].
• The quantity of FPF and the lung weight/body weight ratio were both significantly less in the isoxsuprine-treated fetuses than in control fetuses [5].

Psychiatry related information on isoxsuprine

• PURPOSE: We evaluated the efficacy and safety of yohimbine and isoxsuprine or pentoxifylline in the management of vasculogenic erectile dysfunction [6].

High impact information on isoxsuprine

• A randomized crossover study was performed using 5.4 mg. yohimbine plus 10 mg. isoxsuprine or 400 mg. pentoxifylline 3 times daily [6].
• Penile haemodynamic changes following intravenous injection of the vasodilator isoxsuprine hydrochloride were assessed by quantitation of penile blood flow and volume [7].
• Decreased viscosity of human erythrocyte suspension induced by chlorpromazine and isoxsuprine [8].
• We conclude that isoxsuprine increases synthesis, storage, and release of surfactant in rabbit fetuses at 26 days gestation [9].
• Analysis of the effects of isoxsuprine on guinea-pig atria and trachea [proceedings] [10].

Chemical compound and disease context of isoxsuprine

• The hospital courses and anthropomorphic, developmental, and neurologic development of 201 infants exposed to one or more beta-sympathomimetic agents (isoxsuprine, 33; ritodrine, 70; terbutaline, 43; combination, 55) were analyzed and compared with those of 130 control infants of similar birth weight [11].
• Phentolamine, dihydroergocristine and isoxsuprine were compared for their effects on the blood pressure in anaesthetized normotensive rats, in rats made hypotensive by ganglionic blockade or by pithing and in rats with noradrenaline-induced hypertension [12].
• Pulmonary edema occurring after isoxsuprine and dexamethasone treatment for preterm labor: Case report [13].
• In four other patients treated with isoxsuprine for pregnancy complications, changes in plasma total estrogen concentrations during treatment were variable and did not correlate with the amount administered [14].
• The mean time from presentation to delivery and mean birth weight were 21.8 days and 2510 g respectively in isoxsuprine hydrochloride treated cases and 34.2 days and 2750 g respectively in cases treated with nifedipine [15].

Biological context of isoxsuprine

• Normal doses of ritodrine and isoxsuprine increased the maternal heart rate to 110 to 120 beats/minute and also doubled the PRA level [16].
• Dipyridamole, isoxsuprine, protricular and systemic blood pressure [17].
• The effects of intravenous isoxsuprine on blood viscosity in patients with occlusive peripheral arterial disease [18].
• This indicates that isoxsuprine decreased the peak sodium current during the action potential [19].
• An obstetric alternative to premature labor is administration of isoxsuprine, an effective inhibitor of uterine contractions [20].

Anatomical context of isoxsuprine

• The use of isoxsuprine and the length of time membranes were ruptured before delivery were unrelated to the incidence of RDS [21].
• 3 A 48 h infusion of isoxsuprine (10 mg/h) resulted in a marked depression of lymphocyte beta-adrenoceptor responsiveness (P less than 0.001) [22].
• Papaverine and isoxsuprine injections into the vertebral artery released both early and late spasm [23].
• The apparently low incidence of respiratory distress syndrome in babies born prematurely after intrauterine transfusion and the simultaneous prophylactic administration of intravenous isoxsuprine (a beta-sympathomimetic agent) was investigated by serial study of amniotic fluid lecithin/sphingomyelin ratios [24].
• Isoxsuprine is used to treat navicular disease and other lower-limb problems in the horse [25].

Associations of isoxsuprine with other chemical compounds

• Both fenoterol and isoxsuprine treatment increased the maternal heart rate significantly [26].
• Long-term management with bed rest, phenytoin, and isoxsuprine hydrochloride resulted in term delivery [27].
• An excised muscle strip technique was used as a screening procedure for pharmacologic depression of human uterine activity in vitro, testing isoxsuprine, mesuprine, Alupent, ritodrine, indomethacin, and fenoprofen [28].
• OBJECTIVE: To determine in vitro vasomotor response of equine large colon arterial and venous rings with and without endothelium to vasodilator drugs, including dopamine (DOP), dopexamine (DPX), acepromazine (ACE), isoxsuprine (ISX), and nifedipine (NFP) [29].
• Effect of beta-mimetic isoxsuprine on prostaglandin biosynthesis in pregnant human myometrium in vitro [30].

Gene context of isoxsuprine

• Lung antioxidant enzyme activities for superoxide dismutase, catalase, and glutathione peroxidase were the same at birth in the isoxsuprine-treated and control rat pups, and the enzyme activities increased in response to hyperoxic exposure in each group to an equivalent degree [31].
• Additional in vitro studies showed an affinity of isoxsuprine to both melanin and keratin [32].
• A solid phase extraction method with a Sep-Pak C18 cartridge was used to isolate the drug and isoxsuprine (internal standard) from plasma [33].
• Oxytocin had no effect on gap junction formation but isoxsuprine decreased their number and increased their size [34].

Analytical, diagnostic and therapeutic context of isoxsuprine

• The study was performed in a double-blind cross-over study of isoxsuprine v placebo in ten patients with peripheral arterial insufficiency [1].
• Determination of isoxsuprine in equine plasma by high-performance liquid chromatography with electrochemical detection [35].
• Both premature rupture of the membranes and tocolytic therapy with isoxsuprine were individually associated with a lowered incidence of respiratory distress syndrome [36].
• The ratio rose very significantly after intrauterine transfusions and significantly (but less markedly) after the administration of intravenous isoxsuprine alone [24].
• Six crossbred unanesthetized pregnant ewes were used to determine the effects on fetal and maternal cardiovascular and acid-base status of 10 maternal intravenous infusions of 30 mg isoxsuprine over 30 minutes (1 mg/min) [20].

References