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Chemical Compound Review

Taurodeoxycholate     2-[4-[(3R,10S,12S,13R)-3,12- dihydroxy-10...

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Disease relevance of Taurodeoxycholate


High impact information on Taurodeoxycholate


Chemical compound and disease context of Taurodeoxycholate


Biological context of Taurodeoxycholate


Anatomical context of Taurodeoxycholate

  • Water and electrolyte absorption continued undisturbed when the gallbladders were exposed to 16.7 mM taurodeoxycholate together with 5.6 mM lecithin [15].
  • We have compared the potentially injurious effect of physiologic concentrations of trypsin, taurodeoxycholate, and pepsin at pH 7.5 using a continuously perfused rabbit esophagus model [1].
  • After 4 days of biliary drainage, rat livers were perfused in vitro in either forward (through the portal vein) or backward direction (through the vena cava) in single-pass arrangement with taurodeoxycholate (32 nmol.min-1.g liver-1) [8].
  • The enzyme reaction was optimal above pH 5.5, and a 2-3-fold stimulation of activity was observed when the membranes were assayed in the presence of 0.1% taurodeoxycholate [16].
  • Treatment of intact coated vesicles with pronase (0.05 mg/ml) had little effect on lysosomal enzyme activities, whereas a similar treatment of coated vesicles in the presence of 0.045% taurodeoxycholate resulted in the loss of most of the enzyme activities [17].

Associations of Taurodeoxycholate with other chemical compounds


Gene context of Taurodeoxycholate


Analytical, diagnostic and therapeutic context of Taurodeoxycholate

  • Swine livers were harvested after the intravenous infusion of 1 of 3 solutions: saline (n = 7), tauroursodeoxycholate ([TUDC] hydrophilic; n = 4), or taurodeoxycholate ([TDC] hydrophobic; n = 4) [27].
  • These bile salts also reduced crystallization dose dependently after addition of taurodeoxycholate to vesicles [28].
  • Cow, goat, and human globules were subjected to varying concentrations of the bile salt taurodeoxycholate at 37 degrees C for 2 min, and the released material was obtained by centrifugation at 2 degrees C and 50,000 g for 1 h [29].
  • Taurochenodeoxycholate 3,7-disulphate and taurodeoxycholate 3,12-disulphate in human urine were unequivocally identified on the basis of their behavior in HPLC using mobile phases of different pH [30].
  • This process of derivatization was carried out efficiently and in a nonselective manner over a period of 30 min at 90 degrees C. The resulting derivatives were separated with high resolution by capillary electrophoresis using borate buffer, containing taurodeoxycholate, as the separation buffer [31].


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  2. Conjugates of ursodeoxycholate protect against cholestasis and hepatocellular necrosis caused by more hydrophobic bile salts. In vivo studies in the rat. Heuman, D.M., Mills, A.S., McCall, J., Hylemon, P.B., Pandak, W.M., Vlahcevic, Z.R. Gastroenterology (1991) [Pubmed]
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  19. Artificial bile inhibits bile salt-induced gallbladder glycoprotein release in vitro. O'Leary, D.P. Hepatology (1994) [Pubmed]
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  25. Uncoupling of biliary phospholipid and cholesterol secretion in mice with reduced expression of mdr2 P-glycoprotein. Oude Elferink, R.P., Ottenhoff, R., van Wijland, M., Frijters, C.M., van Nieuwkerk, C., Groen, A.K. J. Lipid Res. (1996) [Pubmed]
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  31. High resolution and rapid analysis of branched oligosaccharides by capillary electrophoresis. Camilleri, P., Harland, G.B., Okafo, G. Anal. Biochem. (1995) [Pubmed]
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