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CHGB  -  chromogranin B (secretogranin 1)

Bos taurus

 
 
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Disease relevance of CHGB

 

High impact information on CHGB

 

Biological context of CHGB

 

Anatomical context of CHGB

 

Associations of CHGB with chemical compounds

  • Presence of a nucleoplasmic complex composed of the inositol 1,4,5-trisphosphate receptor/Ca2+ channel, chromogranin B, and phospholipids [9].
  • Hence, we found in the present study the presence of a nucleoplasmic complex, which is composed of the IP(3)R, CGB, and phospholipids, with an estimated molecular mass of approximately 2-3 x 10(7) Da, suggesting the possibility of the presence of an IP(3)-sensitive Ca(2+) store in the nucleoplasm [9].
  • As to five new peptides related to chromogranin B, prominent protonated molecules were observed at m/z 1746, 1446, 1333, 977 and 901 [13].
  • Biogenesis of chromaffin granules: incorporation of sulfate into chromogranin B and into a proteoglycan [14].
  • General serine protease inhibitors, heavy metal cations (Zn2+ and Hg2+), and the heavy metal chelator 1,10-phenanthroline partially or totally inhibited the proteolytic activity of PSA toward SPMIP/SgI [15].
 

Other interactions of CHGB

 

Analytical, diagnostic and therapeutic context of CHGB

References

  1. Chromogranin B: isolation from pheochromocytoma, N-terminal sequence, tissue distribution and secretory vesicle processing. Gill, B.M., Barbosa, J.A., Dinh, T.Q., Garrod, S., O'Connor, D.T. Regul. Pept. (1991) [Pubmed]
  2. Interaction of chromogranin B and the near N-terminal region of chromogranin B with an intraluminal loop peptide of the inositol 1,4, 5-trisphosphate receptor. Yoo, S.H., Lewis, M.S. J. Biol. Chem. (2000) [Pubmed]
  3. Effects of pH and Ca2+ on heterodimer and heterotetramer formation by chromogranin A and chromogranin B. Yoo, S.H., Lewis, M.S. J. Biol. Chem. (1996) [Pubmed]
  4. pH- and Ca(2+)-induced conformational change and aggregation of chromogranin B. Comparison with chromogranin A and implication in secretory vesicle biogenesis. Yoo, S.H. J. Biol. Chem. (1995) [Pubmed]
  5. Analysis of the substrate specificity of tyrosylprotein sulfotransferase using synthetic peptides. Niehrs, C., Kraft, M., Lee, R.W., Huttner, W.B. J. Biol. Chem. (1990) [Pubmed]
  6. Nucleotide and deduced amino acid sequence of bovine adrenal medulla chromogranin B (secretogranin I). Grandy, D.K., Leduc, R., Makam, H., Flanagan, T., Diliberto, E.J., Civelli, O., Viveros, O.H. Cell. Mol. Neurobiol. (1992) [Pubmed]
  7. Large dense-core secretory granule biogenesis is under the control of chromogranin A in neuroendocrine cells. Kim, T., Tao-Cheng, J.H., Eiden, L.E., Loh, Y.P. Ann. N. Y. Acad. Sci. (2002) [Pubmed]
  8. Characterization and location of post-translational modifications on chromogranin B from bovine adrenal medullary chromaffin granules. Gasnier, C., Lugardon, K., Ruh, O., Strub, J.M., Aunis, D., Metz-Boutigue, M.H. Proteomics (2004) [Pubmed]
  9. Presence of a nucleoplasmic complex composed of the inositol 1,4,5-trisphosphate receptor/Ca2+ channel, chromogranin B, and phospholipids. Yoo, S.H., Nam, S.W., Huh, S.K., Park, S.Y., Huh, Y.H. Biochemistry (2005) [Pubmed]
  10. Identification of the secretory vesicle membrane binding region of chromogranin B. Yoo, S.H., Kang, Y.K. FEBS Lett. (1997) [Pubmed]
  11. Antibacterial activity of secretolytin, a chromogranin B-derived peptide (614-626), is correlated with peptide structure. Strub, J.M., Hubert, P., Nullans, G., Aunis, D., Metz-Boutigue, M.H. FEBS Lett. (1996) [Pubmed]
  12. Processing of chromogranin B in bovine adrenal medulla. Identification of secretolytin, the endogenous C-terminal fragment of residues 614-626 with antibacterial activity. Strub, J.M., Garcia-Sablone, P., Lonning, K., Taupenot, L., Hubert, P., Van Dorsselaer, A., Aunis, D., Metz-Boutigue, M.H. Eur. J. Biochem. (1995) [Pubmed]
  13. Mass spectrometric characterization of bovine chromaffin granule peptides related to chromogranin B. Dillen, L., Boel, S., De Potter, W.P., Claeys, M. Biochim. Biophys. Acta (1992) [Pubmed]
  14. Biogenesis of chromaffin granules: incorporation of sulfate into chromogranin B and into a proteoglycan. Falkensammer, G., Fischer-Colbrie, R., Winkler, H. J. Neurochem. (1985) [Pubmed]
  15. Characterization of prostate-specific antigen proteolytic activity on its major physiological substrate, the sperm motility inhibitor precursor/semenogelin I. Robert, M., Gibbs, B.F., Jacobson, E., Gagnon, C. Biochemistry (1997) [Pubmed]
  16. Characterisation of N-terminal chromogranin A and chromogranin B in mammals by region-specific radioimmunoassays and chromatographic separation methods. Stridsberg, M., Angeletti, R.H., Helle, K.B. J. Endocrinol. (2000) [Pubmed]
  17. Processing of chromogranins in chromaffin cell culture: effects of reserpine and alpha-methyl-p-tyrosine. Wolkersdorfer, M., Laslop, A., Lazure, C., Fischer-Colbrie, R., Winkler, H. Biochem. J. (1996) [Pubmed]
  18. Detection of low molecular mass GTP-binding proteins in chromaffin granules and other subcellular fractions of chromaffin cells. Doucet, J.P., Fournier, S., Parulekar, M., Trifaró, J.M. FEBS Lett. (1989) [Pubmed]
  19. Cellular localization of a chromogranin B-like derived peptides in leeches. Salzet, M., Verger-Bocquet, M. Neuro Endocrinol. Lett. (2002) [Pubmed]
 
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