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CREB1  -  cAMP responsive element binding protein 1

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Disease relevance of CREB1

 

High impact information on CREB1

  • Deacetylase inhibitors and the viral transactivator TaxBLV synergistically activate bovine leukemia virus gene expression via a cAMP-responsive element- and cAMP-responsive element-binding protein-dependent mechanism [5].
  • Our results together suggest that an increase in CREB/ATF occupancy of the viral CREs in response to HDACi potentiates Tax(BLV) transactivation of the BLV promoter [5].
  • Consistent with these functional properties, active CREB decreased the expression of multiple cell cycle regulatory genes, as well as genes encoding growth factors, growth factor receptors, and cytokines [3].
  • Chronic oxidative challenge similar to the microenvironment in diabetes (glucose oxidase treatment) decreases CREB content (40-50%) [6].
  • In vessels from neonatal calves exposed to chronic hypoxia, CREB content was depleted and smooth muscle cell (SMC) proliferation was accelerated [3].
 

Chemical compound and disease context of CREB1

  • In the absence of the tax transactivator, the CREB2 protein and the cyclic AMP-dependent protein kinase A activate the BLV long terminal repeat at a basal expression level: trans activation reached 10% of the values obtained in the presence of tax alone [2].
 

Biological context of CREB1

 

Anatomical context of CREB1

  • An antibody directed toward the cyclic AMP-responsive element binding (CREB) protein supershifted a complex (C1) present only in BLV-infected B lymphocytes [1].
  • In this study, we evaluated the effect of AII stimulation on CREB phosphorylation at Ser133 (pCREB) in bovine adrenal chromaffin cells (BACC) [8].
  • These results demonstrate a critical role for CREB in thyroid growth, differentiation, and function in vivo [10].
  • A protein fraction with high binding affinity for an ATF/CREB-like binding element, GTGACGTCAC, at -49 to -40 in the core beta-polymerase promoter has been purified to near-homogeneity from a nuclear extract of bovine testes [11].
  • We examined the effects of forskolin, an activator of adenylate cyclase, on DNA synthesis, cyclin D1 expression, and cAMP response element-binding protein (CREB) phosphorylation and DNA binding in bovine tracheal myocytes [12].
 

Associations of CREB1 with chemical compounds

  • In addition, we observed that in vitro tax-induced trans activation can be activated or inhibited by CREB2 depending on the presence or absence of protein kinase A. These data suggest that the cyclic AMP pathway plays a role in the regulation of viral expression in BLV-infected animals [2].
  • We also found that AII promotes a rapid and reversible increase in the activity of the non-receptor tyrosine kinase Src and that the inhibition of this enzyme completely blocks the AII-induced phosphorylation of ERK1/2, the CREB kinase (p90)RSK and CREB [8].
  • Treatment of insulin-resistant animals with the insulin sensitizer rosiglitazone restores vessel wall CREB content toward that observed in normal animals [6].
  • Nuclear integration of glucocorticoid receptor and nuclear factor-kappaB signaling by CREB-binding protein and steroid receptor coactivator-1 [13].
  • SMC exposed to oxidative stress (H(2)O(2)) demonstrated a 3.5-fold increase in chemokinesis (p < 0.05) and accelerated entry into cell cycle, accompanied by a significant decrease in CREB content [6].
 

Other interactions of CREB1

 

Analytical, diagnostic and therapeutic context of CREB1

References

  1. Involvement of the cyclic AMP-responsive element binding protein in bovine leukemia virus expression in vivo. Adam, E., Kerkhofs, P., Mammerickx, M., Kettmann, R., Burny, A., Droogmans, L., Willems, L. J. Virol. (1994) [Pubmed]
  2. A cyclic AMP-responsive DNA-binding protein (CREB2) is a cellular transactivator of the bovine leukemia virus long terminal repeat. Willems, L., Kettmann, R., Chen, G., Portetelle, D., Burny, A., Derse, D. J. Virol. (1992) [Pubmed]
  3. cAMP response element-binding protein content is a molecular determinant of smooth muscle cell proliferation and migration. Klemm, D.J., Watson, P.A., Frid, M.G., Dempsey, E.C., Schaack, J., Colton, L.A., Nesterova, A., Stenmark, K.R., Reusch, J.E. J. Biol. Chem. (2001) [Pubmed]
  4. The presence of transcription factors in fetal bovine sera. Knepper, P.A., Mayanil, C.S., Goossens, W., McLone, D.C., Hayes, E. In Vitro Cell. Dev. Biol. Anim. (1998) [Pubmed]
  5. Deacetylase inhibitors and the viral transactivator TaxBLV synergistically activate bovine leukemia virus gene expression via a cAMP-responsive element- and cAMP-responsive element-binding protein-dependent mechanism. Nguyên, T.L., Calomme, C., Wijmeersch, G., Nizet, S., Veithen, E., Portetelle, D., de Launoit, Y., Burny, A., Van Lint, C. J. Biol. Chem. (2004) [Pubmed]
  6. Diabetes-related changes in cAMP response element-binding protein content enhance smooth muscle cell proliferation and migration. Watson, P.A., Nesterova, A., Burant, C.F., Klemm, D.J., Reusch, J.E. J. Biol. Chem. (2001) [Pubmed]
  7. Calcium-independent phospholipase A2 mediates CREB phosphorylation in double-stranded RNA-stimulated endothelial cells. Martinson, B.D., Albert, C.J., Corbett, J.A., Wysolmerski, R.B., Ford, D.A. J. Lipid Res. (2003) [Pubmed]
  8. Angiotensin II promotes the phosphorylation of cyclic AMP-responsive element binding protein (CREB) at Ser133 through an ERK1/2-dependent mechanism. Cammarota, M., Bevilaqua, L.R., Dunkley, P.R., Rostas, J.A. J. Neurochem. (2001) [Pubmed]
  9. Nucleotide sequence of the bovine cyclic-AMP responsive DNA binding protein (CREB2) cDNA. Willems, L., Kettmann, R., Chen, G., Portetelle, D., Burny, A., Derse, D. DNA Seq. (1991) [Pubmed]
  10. A dominant negative CREB (cAMP response element-binding protein) isoform inhibits thyrocyte growth, thyroid-specific gene expression, differentiation, and function. Nguyen, L.Q., Kopp, P., Martinson, F., Stanfield, K., Roth, S.I., Jameson, J.L. Mol. Endocrinol. (2000) [Pubmed]
  11. Mammalian beta-polymerase promoter: large-scale purification and properties of ATF/CREB palindrome binding protein from bovine testes. Widen, S.G., Wilson, S.H. Biochemistry (1991) [Pubmed]
  12. Forskolin inhibits cyclin D1 expression in cultured airway smooth-muscle cells. Musa, N.L., Ramakrishnan, M., Li, J., Kartha, S., Liu, P., Pestell, R.G., Hershenson, M.B. Am. J. Respir. Cell Mol. Biol. (1999) [Pubmed]
  13. Nuclear integration of glucocorticoid receptor and nuclear factor-kappaB signaling by CREB-binding protein and steroid receptor coactivator-1. Sheppard, K.A., Phelps, K.M., Williams, A.J., Thanos, D., Glass, C.K., Rosenfeld, M.G., Gerritsen, M.E., Collins, T. J. Biol. Chem. (1998) [Pubmed]
  14. The CREB, ATF-1, and ATF-2 transcription factors from bovine leukemia virus-infected B lymphocytes activate viral expression. Adam, E., Kerkhofs, P., Mammerickx, M., Burny, A., Kettman, R., Willems, L. J. Virol. (1996) [Pubmed]
  15. Both inducible and constitutive activator protein-1-like transcription factors are used for transcriptional activation of the galanin gene by different first and second messenger pathways. Anouar, Y., Lee, H.W., Eiden, L.E. Mol. Pharmacol. (1999) [Pubmed]
 
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