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Gene Review

LHCGR  -  luteinizing hormone/choriogonadotropin...

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Disease relevance of LHCGR


High impact information on LHCGR


Biological context of LHCGR

  • Specific binding of [3H]progesterone overlapped with the distributions of 5'-nucleotidase and luteinizing hormone receptor (luteal cell surface membrane markers) in both control and digitonin-treated gradients at all stages of the luteal phase [8].
  • Messenger ribonucleic acid expression for growth hormone receptor, luteinizing hormone receptor, and steroidogenic enzymes during the estrous cycle and pregnancy in porcine and bovine corpora lutea [9].
  • This oocyte-cumulus cell interaction, in general, prevents luteinization of cumulus cells by promoting growth, regulating steroidogenesis and inhibin synthesis, and suppressing luteinizing hormone receptor expression [10].
  • The appearance of LH-R antibody was associated with a decline in the serum progesterone concentrations to a range of 0-0.5 ng/ml until day 365 in the immunized dogs in comparison with a range of 5-10 ng in the control animals, suggesting a lack of ovulation and corpus luteum function in immunized dogs [2].
  • The PCR-RFLP analysis made it possible to identify the LHR and FSHR genotypes, as well as to characterize the degree of heterozygosis, which was high for all of the breed compositions, for both loci, except for two combinations for LHR (B and C) [11].

Anatomical context of LHCGR


Associations of LHCGR with chemical compounds

  • Detection of LH-R antibody was associated with suppression of serum progesterone to < or = 0.5 ng/mL during the study period, compared with concentrations of 5 to 10 ng/mL in control cats [12].

Other interactions of LHCGR

  • In addition, mitochondrial DNA ND5 in proportion to a nuclear gene (luteinizing hormone receptor) was determined at the 1st, 2nd, 3rd, 10th, and 15th passages using semi-quantitative PCR amplification [13].

Analytical, diagnostic and therapeutic context of LHCGR

  • Methods: CHO-TSHR, CHO-LHR, and CHO-FSHR cells were incubated with bovine TSH (0.1-25mU/mL), human recombinant chorionic gonadotropin (hCG; 0.5-10mU/mL) or human recombinant FSH (100-5000mU/mL) or with M22 IgG (0.001-5.0 microg/mL), and the extracellular cyclic AMP was measured by radioimmunoassay [7].
  • CONCLUSIONS AND CLINICAL RELEVANCE: Active immunization with LH-R suppressed corpus luteum function in cats [12].


  1. Dominant bovine ovarian follicular cysts express increased levels of messenger RNAs for luteinizing hormone receptor and 3 beta-hydroxysteroid dehydrogenase delta(4),delta(5) isomerase compared to normal dominant follicles. Calder, M.D., Manikkam, M., Salfen, B.E., Youngquist, R.S., Lubahn, D.B., Lamberson, W.R., Garverick, H.A. Biol. Reprod. (2001) [Pubmed]
  2. Modulation of ovarian function in female dogs immunized with bovine luteinizing hormone receptor. Saxena, B.B., Clavio, A., Singh, M., Rathnam, P., Bukharovich, Y., Reimers, T., Saxena, A., Perkins, S. Reprod. Domest. Anim. (2002) [Pubmed]
  3. An N-linked glycosylation motif from the noncleaving luteinizing hormone receptor substituted for the homologous region (Gly367 to Glu369) of the thyrotropin receptor prevents cleavage at its second, downstream site. Kakinuma, A., Chazenbalk, G.D., Tanaka, K., Nagayama, Y., McLachlan, S.M., Rapoport, B. J. Biol. Chem. (1997) [Pubmed]
  4. Granulosa cells promote differentiation of cortical stromal cells into theca cells in the bovine ovary. Orisaka, M., Tajima, K., Mizutani, T., Miyamoto, K., Tsang, B.K., Fukuda, S., Yoshida, Y., Kotsuji, F. Biol. Reprod. (2006) [Pubmed]
  5. Changes in messenger ribonucleic acid encoding luteinizing hormone receptor, cytochrome P450-side chain cleavage, and aromatase are associated with recruitment and selection of bovine ovarian follicles. Bao, B., Garverick, H.A., Smith, G.W., Smith, M.F., Salfen, B.E., Youngquist, R.S. Biol. Reprod. (1997) [Pubmed]
  6. Steady-state luteinizing hormone receptor messenger ribonucleic acid levels and endothelial cell composition in bovine normal- and short-lived corpora lutea. Smith, G.D., Sawyer, H.R., Mirando, M.A., Griswold, M.D., Sadhu, A., Reeves, J.J. Biol. Reprod. (1996) [Pubmed]
  7. Effects of a Thyroid-Stimulating Human Monoclonal Autoantibody (M22) on Functional Activity of LH and FSH Receptors. Tonacchera, M., Ferrarini, E., Dimida, A., Agretti, P., Marco, G.D., Pinchera, A., Sanders, J., Evans, M., Richards, T., Furmaniak, J., Smith, B.R. Thyroid (2006) [Pubmed]
  8. Bovine ovarian non-genomic progesterone binding sites: presence in follicular and luteal cell membranes. Rae, M.T., Menzies, G.S., Bramley, T.A. J. Endocrinol. (1998) [Pubmed]
  9. Messenger ribonucleic acid expression for growth hormone receptor, luteinizing hormone receptor, and steroidogenic enzymes during the estrous cycle and pregnancy in porcine and bovine corpora lutea. Yuan, W., Lucy, M.C. Domest. Anim. Endocrinol. (1996) [Pubmed]
  10. Oocyte-somatic cell interactions during follicle development in mammals. Gilchrist, R.B., Ritter, L.J., Armstrong, D.T. Anim. Reprod. Sci. (2004) [Pubmed]
  11. Genetic characterization of European-Zebu composite bovine using RFLP markers. Marson, E.P., Ferraz, J.B., Meirelles, F.V., Balieiro, J.C., Eler, J.P., Figueiredo, L.G., Mourão, G.B. Genet. Mol. Res. (2005) [Pubmed]
  12. Effect of immunization with bovine luteinizing hormone receptor on ovarian function in cats. Saxena, B.B., Clavio, A., Singh, M., Rathnam, P., Bukharovich, E.Y., Reimers, T.J., Saxena, A., Perkins, S. Am. J. Vet. Res. (2003) [Pubmed]
  13. Increase in mitochondrial DNA quantity and impairment of oxidative phosphorylation in bovine fibroblast cells treated with ethidium bromide for 15 passages in culture. Chiaratti, M.R., Meirelles, F.V. Genet. Mol. Res. (2006) [Pubmed]
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