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Gene Review

Lhcgr  -  luteinizing hormone/choriogonadotropin...

Mus musculus

Synonyms: Gpcr19-rs1, LH-R, LH/CG-R, LSH-R, Lhr, ...
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Disease relevance of Lhcgr


High impact information on Lhcgr


Biological context of Lhcgr


Anatomical context of Lhcgr


Associations of Lhcgr with chemical compounds


Other interactions of Lhcgr


Analytical, diagnostic and therapeutic context of Lhcgr

  • After calibration in a mouse Leydig cell bioassay against the WHO LH80/522 standard, the ED (50) of the CG preparation on a COS7 cell line permanently expressing the marmoset LHR was 4.25 +/- 0.21 IU/L (n = 3) [18].
  • Use of tritiated thymidine incorporation and autoradiography to label dividing amastigotes showed equivalent multiplication of the parasite in liver macrophages from Lshs and Lshr mice between 24 h and 48 h after infection in vitro, with a dramatic difference observed thereafter [23].


  1. Genetic heterogeneity of constitutively activating mutations of the human luteinizing hormone receptor in familial male-limited precocious puberty. Laue, L., Chan, W.Y., Hsueh, A.J., Kudo, M., Hsu, S.Y., Wu, S.M., Blomberg, L., Cutler, G.B. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  2. An ultrastructural investigation of Leishmania donovani infection in genetically resistant and susceptible mouse strains. Weldon, P.R., Kongshavn, P.A. Can. J. Microbiol. (1985) [Pubmed]
  3. Fertility in luteinizing hormone receptor-knockout mice after wild-type ovary transplantation demonstrates redundancy of extragonadal luteinizing hormone action. Pakarainen, T., Zhang, F.P., Poutanen, M., Huhtaniemi, I. J. Clin. Invest. (2005) [Pubmed]
  4. Brain abnormalities, defective meiotic chromosome synapsis and female subfertility in HSF2 null mice. Kallio, M., Chang, Y., Manuel, M., Alastalo, T.P., Rallu, M., Gitton, Y., Pirkkala, L., Loones, M.T., Paslaru, L., Larney, S., Hiard, S., Morange, M., Sistonen, L., Mezger, V. EMBO J. (2002) [Pubmed]
  5. The low gonadotropin-independent constitutive production of testicular testosterone is sufficient to maintain spermatogenesis. Zhang, F.P., Pakarainen, T., Poutanen, M., Toppari, J., Huhtaniemi, I. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  6. Receptors for anti-müllerian hormone on Leydig cells are responsible for its effects on steroidogenesis and cell differentiation. Racine, C., Rey, R., Forest, M.G., Louis, F., Ferré, A., Huhtaniemi, I., Josso, N., di Clemente, N. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  7. Dependence of uterine cyclooxygenase2 expression on luteinizing hormone signaling. Lin, D.X., Lei, Z.M., Rao, C.h.V. Biol. Reprod. (2005) [Pubmed]
  8. Normal prenatal but arrested postnatal sexual development of luteinizing hormone receptor knockout (LuRKO) mice. Zhang, F.P., Poutanen, M., Wilbertz, J., Huhtaniemi, I. Mol. Endocrinol. (2001) [Pubmed]
  9. Knockout of luteinizing hormone receptor abolishes the effects of follicle-stimulating hormone on preovulatory maturation and ovulation of mouse graafian follicles. Pakarainen, T., Zhang, F.P., Nurmi, L., Poutanen, M., Huhtaniemi, I. Mol. Endocrinol. (2005) [Pubmed]
  10. Luteinizing hormone receptor knockout (LuRKO) mice and transgenic human chorionic gonadotropin (hCG)-overexpressing mice (hCG alphabeta+) have bone phenotypes. Yarram, S.J., Perry, M.J., Christopher, T.J., Westby, K., Brown, N.L., Lamminen, T., Rulli, S.B., Zhang, F.P., Huhtaniemi, I., Sandy, J.R., Mansell, J.P. Endocrinology (2003) [Pubmed]
  11. Identification and structural characterization of the neuronal luteinizing hormone receptor associated with sensory systems. Apaja, P.M., Harju, K.T., Aatsinki, J.T., Petäjä-Repo, U.E., Rajaniemi, H.J. J. Biol. Chem. (2004) [Pubmed]
  12. Homologous desensitization of the murine luteinizing hormone receptor expressed in L cells. Gudermann, T., Birnbaumer, M., Birnbaumer, L. Mol. Cell. Endocrinol. (1995) [Pubmed]
  13. Transgenic mice harboring murine luteinizing hormone receptor promoter/beta-galactosidase fusion genes: different structural and hormonal requirements of expression in the testis, ovary, and adrenal gland. Hämäläinen, T., Kero, J., Poutanen, M., Huhtaniemi, I. Endocrinology (2002) [Pubmed]
  14. Assessment of mechanisms of thyroid hormone action in mouse Leydig cells: regulation of the steroidogenic acute regulatory protein, steroidogenesis, and luteinizing hormone receptor function. Manna, P.R., Kero, J., Tena-Sempere, M., Pakarinen, P., Stocco, D.M., Huhtaniemi, I.T. Endocrinology (2001) [Pubmed]
  15. Mouse oocytes suppress cAMP-induced expression of LH receptor mRNA by granulosa cells in vitro. Eppig, J.J., Pendola, F.L., Wigglesworth, K. Mol. Reprod. Dev. (1998) [Pubmed]
  16. Testosterone replacement therapy induces spermatogenesis and partially restores fertility in luteinizing hormone receptor knockout mice. Pakarainen, T., Zhang, F.P., Mäkelä, S., Poutanen, M., Huhtaniemi, I. Endocrinology (2005) [Pubmed]
  17. Progesterone can participate in down-regulation of the luteinizing hormone receptor gene expression and function in cultured murine Leydig cells. El-Hefnawy, T., Huhtaniemi, I. Mol. Cell. Endocrinol. (1998) [Pubmed]
  18. The carboxyterminal peptide of chorionic gonadotropin facilitates activation of the marmoset LH receptor. Müller, T., Gromoll, J., Simula, A.P., Norman, R., Sandhowe-Klaverkamp, R., Simoni, M. Exp. Clin. Endocrinol. Diabetes (2004) [Pubmed]
  19. Nramp transfection transfers Ity/Lsh/Bcg-related pleiotropic effects on macrophage activation: influence on oxidative burst and nitric oxide pathways. Barton, C.H., Whitehead, S.H., Blackwell, J.M. Mol. Med. (1995) [Pubmed]
  20. Regulation of luteinizing hormone-receptor and follicle-stimulating hormone-receptor messenger ribonucleic acid levels during development in the neonatal mouse ovary. O'Shaughnessy, P.J., McLelland, D., McBride, M.W. Biol. Reprod. (1997) [Pubmed]
  21. Luteinizing hormone receptor-mediated effects on initiation of spermatogenesis in gonadotropin-deficient (hpg) mice are replicated by testosterone. Spaliviero, J.A., Jimenez, M., Allan, C.M., Handelsman, D.J. Biol. Reprod. (2004) [Pubmed]
  22. Regulation of luteinizing hormone receptor gene expression by insulin-like growth factor-I in an immortalized murine Leydig tumor cell line (BLT-1). Zhang, F.P., El-Hefnawy, T., Huhtaniemi, I., El-Hafnawy, T. Biol. Reprod. (1998) [Pubmed]
  23. Variable expression of the murine natural resistance gene Lsh in different macrophage populations infected in vitro with Leishmania donovani. Crocker, P.R., Davies, E.V., Blackwell, J.M. Parasite Immunol. (1987) [Pubmed]
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