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Gene Review

Lhcgr  -  luteinizing hormone/choriogonadotropin...

Rattus norvegicus

Synonyms: LH/CG-R, LSH-R, LSHR, Lhr, Luteinizing hormone receptor, ...
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Disease relevance of Lhcgr

  • In summary, human uterine leiomyomas express a functional hCG/LH receptor gene at a reduced level compared with that for normal corresponding myometria [1].
  • Our observations indicate that 1) vascular pericytes may play a role in follicular development; 2) LHR expression in granulosa may require an interaction of macrophages, oocytes, and cumulus cells; and 3) thecal hypertrophy accompanied by enhanced LHR expression occurs on follicles undergoing atresia [2].
  • This prompted us to study whether experimental cryptorchidism, known to alter the process of LC repopulation, can influence the pattern of testicular LHR mRNA expression after EDS administration [3].
  • These results indicate that hypothyroidism in animals with insulin resistance and type 2 diabetes promotes LH and testosterone secretions, and suggests that the enhanced-testosterone levels is partially mediated by the enhancement of LH receptor expression and an increase in the serum level of LH [4].
  • Decrease of testosterone level during an experimental African trypanosomiasis: involvement of a testicular LH receptor desensitization [5].

High impact information on Lhcgr


Chemical compound and disease context of Lhcgr


Biological context of Lhcgr


Anatomical context of Lhcgr


Associations of Lhcgr with chemical compounds


Physical interactions of Lhcgr

  • In conclusion, the findings demonstrate that Egr-1 actually binds to the regulatory upstream region of the LH receptor gene and positively regulates receptor gene expression [12].
  • We have developed chimeric GnRHR-LHR that contain the full GnRHR coupled to various forms of the LH receptor C-terminus to explore the role of the LH receptor C-terminus in raft localization of the receptor and signaling [19].
  • Neither GnRH nor GnRH-A affected the binding affinity (Kd) of ovarian LH receptor [20].

Regulatory relationships of Lhcgr


Other interactions of Lhcgr

  • Endogenous association of LHR mRNA with MVK was assessed by immunoprecipitation of the ribonucleoprotein complex with MVK antibody followed by reverse transcription-PCR of the RNA associated with the immune complex [11].
  • Both aromatase inhibitors caused relatively greater inhibition of LH receptor formation when added from 20-48 h of culture, the period during which FSH-stimulated estrogen synthesis occurs (85% maximal inhibition with 4-OHA and 95% with 1,4,6-androstatriene-3,17-dione) [15].
  • Significant suppression of LH-R mRNA levels was only observed in the hypothyroid rat testes at 50 days of age [26].
  • Comparison of the FSHR gene to the LH receptor gene revealed a number of striking similarities which clearly indicate that these receptors evolved through gene duplication [27].
  • The increased expression of ER beta and a concomitant initiation of LHr, P450(scc), and P450(arom) expression in granulosa cells of medium follicles may signify a role for estrogen in follicular development [17].

Analytical, diagnostic and therapeutic context of Lhcgr

  • Northern blot analysis of LHR mRNA showed that rolipram treatment also markedly reduced ovarian LHR mRNA levels by up to 75% [28].
  • A quantitative reverse transcription-polymerase chain reaction amplification scheme was used to measure relative levels of the FSH and LH receptor mRNAs, while in situ hybridization was used to localize FSH and LH receptor transcripts [21].
  • The LH receptor-binding potencies of N(56)dg-eLH alpha:eLH beta t and N(56)dg-eFSH alpha:eLH beta t hybrids were equivalent to that of eLH; however, both N(56)dg-alpha preparations were only 3-4% as active as eLH in the rat testis Leydig cell bioassay [29].
  • Sperm numbers were reduced in animals immunized against either the FSH or LH receptor (FSHR/LHR) [30].
  • In EDS rats, serum T was suppressed and testicular LHR binding became undetectable on days 5 and 15 after treatment [31].


  1. Decreased expression of functional human chorionic gonadotropin/luteinizing hormone receptor gene in human uterine leiomyomas. Singh, M., Zuo, J., Li, X., Ambrus, G., Lei, Z.M., Yussman, M.A., Sanfilippo, J.S., Rao, C.V. Biol. Reprod. (1995) [Pubmed]
  2. Cellular localization of luteinizing hormone receptor immunoreactivity in the ovaries of immature, gonadotropin-primed and normal cycling rats. Bukovský, A., Chen, T.T., Wimalasena, J., Caudle, M.R. Biol. Reprod. (1993) [Pubmed]
  3. Experimental cryptorchidism induces a change in the pattern of expression of LH receptor mRNA in rat testis after selective Leydig cell destruction by ethylene dimethane sulfonate. Tena-Sempere, M., Kero, J., Rannikko, A., Huhtaniemi, I. J. Endocrinol. (1999) [Pubmed]
  4. Changes in ovarian steroidogenesis in insulin-resistant, type 2 diabetic Goto-Kakizaki rats after thyroidectomy and gonadotropin treatment. Tamura, K., Osada, S., Matsushita, M., Abe, K., Kogo, H. Eur. J. Pharmacol. (2005) [Pubmed]
  5. Decrease of testosterone level during an experimental African trypanosomiasis: involvement of a testicular LH receptor desensitization. Soudan, B., Tetaert, D., Racadot, A., Degand, P., Boersma, A. Acta Endocrinol. (1992) [Pubmed]
  6. Co-evolution of ligand-receptor pairs. Moyle, W.R., Campbell, R.K., Myers, R.V., Bernard, M.P., Han, Y., Wang, X. Nature (1994) [Pubmed]
  7. Lutropin-choriogonadotropin receptor: an unusual member of the G protein-coupled receptor family. McFarland, K.C., Sprengel, R., Phillips, H.S., Köhler, M., Rosemblit, N., Nikolics, K., Segaloff, D.L., Seeburg, P.H. Science (1989) [Pubmed]
  8. Hormonal regulation of gonadotropin receptors and steroidogenesis in cultured fetal rat tests. Warren, D.W., Dufau, M.L., Catt, K.J. Science (1982) [Pubmed]
  9. Growth factors modulate gonadotropin receptor induction in granulosa cell cultures. Mondschein, J.S., Schomberg, D.W. Science (1981) [Pubmed]
  10. Effect of troglitazone on the excess testosterone and LH secretion in thyroidectomized, insulin-resistant, type 2 diabetic Goto-Kakizaki rats. Matsushita, M., Tamura, K., Osada, S., Kogo, H. Endocrine (2005) [Pubmed]
  11. Regulation of luteinizing hormone receptor expression: evidence of translational suppression in vitro by a hormonally regulated mRNA-binding protein and its endogenous association with luteinizing hormone receptor mRNA in the ovary. Nair, A.K., Menon, K.M. J. Biol. Chem. (2005) [Pubmed]
  12. Early growth response gene-1 regulates the expression of the rat luteinizing hormone receptor gene. Yoshino, M., Mizutani, T., Yamada, K., Tsuchiya, M., Minegishi, T., Yazawa, T., Kawata, H., Sekiguchi, T., Kajitani, T., Miyamoto, K. Biol. Reprod. (2002) [Pubmed]
  13. Differential responses of an invariant region in the ectodomain of three glycoprotein hormone receptors to mutagenesis and assay conditions. Angelova, K., Puett, D. Endocrine (2002) [Pubmed]
  14. Post-transcriptional regulation of luteinizing hormone receptor mRNA in the ovary by a novel mRNA-binding protein. Nair, A.K., Kash, J.C., Peegel, H., Menon, K.M. J. Biol. Chem. (2002) [Pubmed]
  15. Aromatase inhibitors prevent granulosa cell differentiation: an obligatory role for estrogens in luteinizing hormone receptor expression. Knecht, M., Brodie, A.M., Catt, K.J. Endocrinology (1985) [Pubmed]
  16. Expression of the mature luteinizing hormone receptor in rodent urogenital and adrenal tissues is developmentally regulated at a posttranslational level. Apaja, P.M., Aatsinki, J.T., Rajaniemi, H.J., Petäjä-Repo, U.E. Endocrinology (2005) [Pubmed]
  17. Estrogen receptor-beta expression in relation to the expression of luteinizing hormone receptor and cytochrome P450 enzymes in rat ovarian follicles. Bao, B., Kumar, N., Karp, R.M., Garverick, H.A., Sundaram, K. Biol. Reprod. (2000) [Pubmed]
  18. Human chorionic gonadotropin/luteinizing hormone receptor expression in the adult rat spinal cord. Rao, S.C., Li, X., Rao, C.h.V., Magnuson, D.S. Neurosci. Lett. (2003) [Pubmed]
  19. Chimeric GnRH-LH receptors and LH receptors lacking C-terminus palmitoylation sites do not localize to plasma membrane rafts. Lei, Y., Hagen, G.M., Smith, S.M., Barisas, B.G., Roess, D.A. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  20. Direct inhibitory effect of gonadotropin-releasing hormone upon luteal luteinizing hormone receptor and steroidogenesis in hypophysectomized rats. Jones, P.B., Hsueh, A.J. Endocrinology (1980) [Pubmed]
  21. Cellular localization and hormonal regulation of follicle-stimulating hormone and luteinizing hormone receptor messenger RNAs in the rat ovary. Camp, T.A., Rahal, J.O., Mayo, K.E. Mol. Endocrinol. (1991) [Pubmed]
  22. Tumor necrosis factor-alpha inhibits follicle-stimulating hormone-induced differentiation in cultured rat granulosa cells. Darbon, J.M., Oury, F., Laredo, J., Bayard, F. Biochem. Biophys. Res. Commun. (1989) [Pubmed]
  23. Gonadotropin-releasing hormone and its agonist inhibit testicular luteinizing hormone receptor and steroidogenesis in immature and adult hypophysectomized rats. Bambino, T.H., Schreiber, J.R., Hsueh, A.J. Endocrinology (1980) [Pubmed]
  24. Basic fibroblast growth factor induces luteinizing hormone receptor expression in the presence of insulin-like growth factor-I in ovarian granulosa cells. Kanzaki, M., Hattori, M., Horiuchi, R., Kojima, I. Mol. Cell. Endocrinol. (1994) [Pubmed]
  25. The luteinizing hormone receptor-activated extracellularly regulated kinase-1/2 cascade stimulates epiregulin release from granulosa cells. Andric, N., Ascoli, M. Endocrinology (2008) [Pubmed]
  26. Effect of thyroid hormone on the development and gene expression of hormone receptors in rat testes in vivo. Rao, J.N., Liang, J.Y., Chakraborti, P., Feng, P. J. Endocrinol. Invest. (2003) [Pubmed]
  27. Structural organization of the follicle-stimulating hormone receptor gene. Heckert, L.L., Daley, I.J., Griswold, M.D. Mol. Endocrinol. (1992) [Pubmed]
  28. A novel mechanism for the modulation of luteinizing hormone receptor mRNA expression in the rat ovary. Peegel, H., Towns, R., Nair, A., Menon, K.M. Mol. Cell. Endocrinol. (2005) [Pubmed]
  29. Truncated equine LH beta and asparagine(56)-deglycosylated equine LH alpha combine to produce a potent FSH antagonist. Butnev, V.Y., Singh, V., Nguyen, V.T., Bousfield, G.R. J. Endocrinol. (2002) [Pubmed]
  30. Decreased spermatogenesis as the result of an induced autoimmune reaction directed against the gonadotropin receptors in male rats. Graf, K.M., Dias, J.A., Griswold, M.D. J. Androl. (1997) [Pubmed]
  31. Molecular mechanisms of reappearance of luteinizing hormone receptor expression and function in rat testis after selective Leydig cell destruction by ethylene dimethane sulfonate. Tena-Sempere, M., Rannikko, A., Kero, J., Zhang, F.P., Huhtaniemi, I.T. Endocrinology (1997) [Pubmed]
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