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Gene Review

FSHR  -  follicle stimulating hormone receptor

Bos taurus

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High impact information on FSHR


Biological context of FSHR

  • We conclude that bovine cervix at the time of the peripheral plasma FSH peak (pre-estrus/estrus) contains high levels of FSHR and responds to FSH by increasing the PGE(2) production responsible for cervical relaxation at estrus [5].
  • The PCR-RFLP analysis made it possible to identify the LHR and FSHR genotypes, as well as to characterize the degree of heterozygosis, which was high for all of the breed compositions, for both loci, except for two combinations for LHR (B and C) [6].
  • Our results suggest that the bovine testis FSH receptor contains predominantly N-linked oligosaccharide chains consistent with recently predicted N-linked glycosylation sites of cloned FSH receptor of rat testis [7].
  • The effectiveness of antibodies against FSH receptor in stimulating estradiol synthesis suggests that the information needed for FSH signal transduction resides in the membrane receptor rather than in the hormone molecule [8].
  • Expression of follicle-stimulating hormone-receptor mRNA alternate transcripts in bovine granulosa cells during luteinization in vivo and in vitro [9].

Anatomical context of FSHR

  • Distinct regulation by steroids of messenger RNAs for FSHR and CYP19A1 in bovine granulosa cells [10].
  • The level of FSHR (75 kDa) was significantly higher (p < 0.01) in Western blots of pre-estrous/estrous cervix than in other cervical tissues [5].
  • In addition, synchronized changes in the pattern of COC IGFBP-2 and FSHR expression during oocyte maturation suggest possible synergistic actions between IGF-1 and FSH [11].
  • The objective of this study was to investigate changes in expression of mRNAs encoding FSH receptor (FSHr), LH receptor (LHr), cytochrome P450 side-chain cleavage (P450(scc)), cytochrome P450 17alpha-hydroxylase (P450(c17)), and cytochrome P450 aromatase (P450(arom)) during recruitment and selection of bovine ovarian follicles [12].
  • For a better characterisation of classes the mRNA expressions of FSH receptor, LH receptor and aromatase cytochrome P450 in theca interna (TI) and granulosa cells (GC) were determined [13].

Associations of FSHR with chemical compounds


Physical interactions of FSHR


Other interactions of FSHR

  • In contrast, levels of IGFBP-2 and FSHR expression decreased (P < 0.05) in matured COC [11].
  • Incubation of FSH (10 ng/ml) with pre-estrous/estrous cervix resulted in a 3-fold increase in the expression of FSHR and a 2-fold increase in both G protein (alpha(s)) and cyclooxygenase II [5].
  • The rate of association of [125I]hFSH with its receptor was reduced by 50% in the presence of aprotinin, but no effect on dissociation of FSH-receptor complexes was evident [15].
  • Our results indicate that recognition of FSH-beta by N-terminus region (9-30) of the FSH receptor involves contact with residues in three discontinuous binding regions on FSH-beta.(ABSTRACT TRUNCATED AT 250 WORDS)[17]
  • One day after luteinization in vivo, full-length FSH-receptor mRNA was detectable at low levels in the newly-formed corpus luteum [9].

Analytical, diagnostic and therapeutic context of FSHR

  • Methods: CHO-TSHR, CHO-LHR, and CHO-FSHR cells were incubated with bovine TSH (0.1-25mU/mL), human recombinant chorionic gonadotropin (hCG; 0.5-10mU/mL) or human recombinant FSH (100-5000mU/mL) or with M22 IgG (0.001-5.0 microg/mL), and the extracellular cyclic AMP was measured by radioimmunoassay [18].
  • The immunoprecipitate, after dissociation of receptor from antibody, separation by SDS-PAGE under reducing conditions, and autoradiography, showed the presence of a approximately 60 kDa protein previously identified as a component of the FSH receptor [8].
  • Using RT-PCR and Southern blotting, three alternate transcripts of the FSH-receptor were found consistently in bovine granulosa cells [9].
  • Nucleotide sequence analysis and alignment of the cloned PCR products showed the presence of two isoforms of the FSH receptor mRNA and two isoforms of the LH receptor mRNA [19].
  • This model system was utilized to study the effects of FSH on the quaternary structure of FSH receptor-associated GTP-binding protein by comparing the gel filtration profiles of proteoliposomes solubilized with Triton X-100 after exposure to [3H]Gpp(NH)p in the presence or absence of FSH [20].


  1. Purification of follitropin receptor from bovine calf testes. Dattatreyamurty, B., Zhang, S.B., Reichert, L.E. J. Biol. Chem. (1990) [Pubmed]
  2. Physical and functional association of follitropin receptors with cholera toxin-sensitive guanine nucleotide-binding protein. Dattatreyamurty, B., Figgs, L.W., Reichert, L.E. J. Biol. Chem. (1987) [Pubmed]
  3. Regulation of follicle-stimulating hormone binding to receptors on bovine calf testis membranes by cholera toxin-sensitive guanine nucleotide binding protein. Zhang, S.B., Dattatreyamurty, B., Reichert, L.E. Mol. Endocrinol. (1988) [Pubmed]
  4. Selection of the dominant follicle in cattle occurs in the absence of differences in the expression of messenger ribonucleic acid for gonadotropin receptors. Evans, A.C., Fortune, J.E. Endocrinology (1997) [Pubmed]
  5. Follicle-stimulating hormone receptor and its messenger ribonucleic acid are present in the bovine cervix and can regulate cervical prostanoid synthesis. Mizrachi, D., Shemesh, M. Biol. Reprod. (1999) [Pubmed]
  6. Genetic characterization of European-Zebu composite bovine using RFLP markers. Marson, E.P., Ferraz, J.B., Meirelles, F.V., Balieiro, J.C., Eler, J.P., Figueiredo, L.G., Mourão, G.B. Genet. Mol. Res. (2005) [Pubmed]
  7. Carbohydrate moiety of follitropin receptor is not required for high affinity hormone-binding or for functional coupling between receptor and guanine nucleotide-binding protein in bovine calf testis membranes. Dattatreyamurty, B., Reichert, L.E. Endocrinology (1992) [Pubmed]
  8. Polyclonal antibodies against follitropin (FSH) receptor interfere with hormone binding, but mimic the effects of FSH. Dattatreyamurty, B., Zhang, S.B., Reichert, L.E. Endocrinology (1990) [Pubmed]
  9. Expression of follicle-stimulating hormone-receptor mRNA alternate transcripts in bovine granulosa cells during luteinization in vivo and in vitro. Rajapaksha, W.R., Robertson, L., O'Shaughnessy, P.J. Mol. Cell. Endocrinol. (1996) [Pubmed]
  10. Distinct regulation by steroids of messenger RNAs for FSHR and CYP19A1 in bovine granulosa cells. Luo, W., Wiltbank, M.C. Biol. Reprod. (2006) [Pubmed]
  11. Expression of components of the insulin-like growth factor system and gonadotropin receptors in bovine cumulus-oocyte complexes during oocyte maturation. Nuttinck, F., Charpigny, G., Mermillod, P., Loosfelt, H., Meduri, G., Freret, S., Grimard, B., Heyman, Y. Domest. Anim. Endocrinol. (2004) [Pubmed]
  12. Changes in messenger ribonucleic acid encoding luteinizing hormone receptor, cytochrome P450-side chain cleavage, and aromatase are associated with recruitment and selection of bovine ovarian follicles. Bao, B., Garverick, H.A., Smith, G.W., Smith, M.F., Salfen, B.E., Youngquist, R.S. Biol. Reprod. (1997) [Pubmed]
  13. Expression and localisation of vascular endothelial growth factor and basic fibroblast growth factor during the final growth of bovine ovarian follicles. Berisha, B., Schams, D., Kosmann, M., Amselgruber, W., Einspanier, R. J. Endocrinol. (2000) [Pubmed]
  14. Gonadotropin requirements for dominant follicle selection in GnRH agonist-treated cows. Hampton, J.H., Bader, J.F., Lamberson, W.R., Smith, M.F., Youngquist, R.S., Garverick, H.A. Reproduction (2004) [Pubmed]
  15. The effects of aprotinin on follicle-stimulating hormone binding and signal transduction in bovine calf testis. Grasso, P., Reichert, L.E. Endocrinology (1989) [Pubmed]
  16. Stabilization of follicle-stimulating hormone-receptor complexes may involve calcium-dependent transglutaminase activation. Grasso, P., Reichert, L.E. Mol. Cell. Endocrinol. (1992) [Pubmed]
  17. Identification of regions of the follitropin (FSH) beta-subunit that interact with the N-terminus region (residues 9-30) of the FSH receptor. Dattatreyamurty, B., Reichert, L.E. Mol. Cell. Endocrinol. (1993) [Pubmed]
  18. Effects of a Thyroid-Stimulating Human Monoclonal Autoantibody (M22) on Functional Activity of LH and FSH Receptors. Tonacchera, M., Ferrarini, E., Dimida, A., Agretti, P., Marco, G.D., Pinchera, A., Sanders, J., Evans, M., Richards, T., Furmaniak, J., Smith, B.R. Thyroid (2006) [Pubmed]
  19. Influence of FSH and hCG on the resumption of meiosis of bovine oocytes surrounded by cumulus cells connected to membrana granulosa. van Tol, H.T., van Eijk, M.J., Mummery, C.L., van den Hurk, R., Bevers, M.M. Mol. Reprod. Dev. (1996) [Pubmed]
  20. Follicle stimulating hormone (FSH) induces G protein dissociation from FSH receptor-G protein complexes in reconstituted proteoliposomes. Grasso, P., Reichert, L.E. Biochem. Biophys. Res. Commun. (1989) [Pubmed]
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