The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

TRBC1  -  T cell receptor beta constant 1

Homo sapiens

Synonyms: BV05S1J2.2, T-cell receptor beta-1 chain C region, TCRB, TCRBC1
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of TRBC1

  • We have recently shown AP-2beta to be linked to personality, binge-eating disorder, treatment with antidepressant drugs, and also to trbc MAO [1].
  • TRBC HA is a reliable test, and feasible in an emergency: it could help in making the appropriate decision for immunoprophylaxis to be applied to the injured and other patients at risk of tetanus [2].
  • GOALS/BACKGROUND: Previous studies have demonstrated low yield and conflicting results as to the ability of technetium-99m labeled red blood cell (TRBC) scintigraphy to accurately localize the site of bleeding in acute lower gastrointestinal hemorrhage [3].
  • Intra-abdominal abscesses developed in three of 46 patients (6.5%), each of whom had a TRBC of >100 units (mean, 160 units) [4].
 

High impact information on TRBC1

  • We describe recent results of studies on the biological marker thrombocyte monoamine oxidase (trbc MAO) and the transcription factor AP-2beta [1].
  • As compared with MG, PG produces a similar immunologic response in rabbits as demonstrated by a tanned red blood cell (TRBC) passive hemagglutination assay or by total serum binding of perennial rye grass Group I antigens (RGGI) [5].
  • METHODS: Calibrated beads and biological standards (lymphocytes, trout erythrocytes [TRBC], calf thymocytes, and tumor cells) were analyzed for ENV versus DNA content [6].
  • Identification of a predominant sequence variant of the T-cell receptor TCRBC1 gene [7].
  • Full-length TCRBC sequence information was derived from a leukocyte cDNA library [8].
 

Chemical compound and disease context of TRBC1

 

Biological context of TRBC1

  • Rainbow trout red blood cells (TRBC) have a DNA content of 80% of human diploid cells [9].
  • Multivariate analysis demonstrated that the number of units of blood transfused within 24 hours prior to the TRBC scan and the lowest recorded hematocrit were significantly different between patients with positive and negative scans [3].
  • We have previously shown that an RFLP of the T-cell antigen receptor constant beta-chain (TCRBC) locus, which is also localized to chromosome 7q35, is strongly associated with susceptibility to microvascular complications [10].
  • The 10/9.2 and 9.2/9.2 kb TCRBC-ALR2 haplotypes were increased in the nephropaths compared to the retinopaths (32.5% versus 8.9% chi 2 = 10.9, p < 0.001) [10].
  • The 10/9.2-8.2 kb TCRBC-ALR2 genotype was significantly decreased in the nephropaths compared to the retinopaths (13.7% versus 43.6%, chi 2 = 10.1, p < 0.0025) [10].
 

Anatomical context of TRBC1

  • H2O2 and OH radicals production in TRBC was considerably reduced when digestion of host cell cytosol was inhibited either by antiproteases (which reduce the proteolysis of imported catalase) or by its alkalinization with NH4Cl (which reduce methemoglobin formation) [11].
 

Associations of TRBC1 with chemical compounds

  • Low levels of trbc MAO is associated with temperamental characteristics such as sensation seeking and impulsiveness, and the enzyme is genetically regulated by specific transcriptional mechanisms [1].
  • Sample acquisition with fine-needle aspiration, storage at -80 degrees C, internal standardization by chicken (CRBC) and trout red blood cells (TRBC), staining with propidium iodide (PI), and analysis in the flow cytometer is recapitulated, with emphasis on previously unpublished aspects [12].
  • Intact Plasmodium falciparum trophozoite-infected human red blood cells (TRBC) were shown to produce H2O2 and OH radicals about twice as much as normal erythrocytes, as evidenced by the inhibition of endogenous catalase activity in the presence of 3-AT and the degradation of deoxyribose, respectively [11].
 

Analytical, diagnostic and therapeutic context of TRBC1

  • Restriction enzyme mapping of B3 located TCRBV and TCRBC gene regions to 4 Sfi I fragments of 280 110, 90, and 125 kbp and was in accordance with published data [13].
  • Southern blot hybridizations demonstrated restriction fragment length polymorphisms at the TCRBC locus among different horse breeds [14].
  • The results also suggest that low trbc MAO activity in criminal offenders is not an artefact of cigarette smoking [15].
  • CONCLUSIONS: TRBC scintigraphy has a relatively low yield in the evaluation of acute lower gastrointestinal bleeding [3].
  • The rapid HA test practiced in emergency was controlled by TRBC HA and ELISA measurement of antibodies carried out in the laboratory [2].

References

  1. Genetic mechanisms of behavior--don't forget about the transcription factors. Damberg, M., Garpenstrand, H., Hallman, J., Oreland, L. Mol. Psychiatry (2001) [Pubmed]
  2. Rapid evaluation of tetanus immunity by a haemagglutination test in the injured at a hospital emergency unit. Beytout, J., Lauras, H., Cailleba, A., Nguyen, T.T. Biomed. Pharmacother. (1989) [Pubmed]
  3. The yield of bleeding scans in acute lower gastrointestinal hemorrhage. Olds, G.D., Cooper, G.S., Chak, A., Sivak, M.V., Chitale, A.A., Wong, R.C. J. Clin. Gastroenterol. (2005) [Pubmed]
  4. Bedside laparotomy for trauma: are there risks? Diaz, J.J., Mauer, A., May, A.K., Miller, R., Guy, J.S., Morris, J.A. Surgical infections. (2004) [Pubmed]
  5. The immune response in humans and rabbits to monomeric and polymeric grass allergens. Hendrix, S.G., Patterson, R., Zeiss, C.R., Suszko, I.M. J. Clin. Immunol. (1982) [Pubmed]
  6. NASA/American Cancer Society High-Resolution Flow Cytometry Project-I. Thomas, R.A., Krishan, A., Robinson, D.M., Sams, C., Costa, F. Cytometry. (2001) [Pubmed]
  7. Identification of a predominant sequence variant of the T-cell receptor TCRBC1 gene. MacLean, S.J., Gibson, D.M. Immunogenetics (1997) [Pubmed]
  8. Cloning of T-cell antigen receptor beta chain cDNAs from Atlantic salmon (Salmo salar). Hordvik, I., Jacob, A.L., Charlemagne, J., Endresen, C. Immunogenetics (1996) [Pubmed]
  9. Standardization of high-resolution flow cytometric DNA analysis by the simultaneous use of chicken and trout red blood cells as internal reference standards. Vindeløv, L.L., Christensen, I.J., Nissen, N.I. Cytometry. (1983) [Pubmed]
  10. Chromosome 7q35 and susceptibility to diabetic microvascular complications. Patel, A., Hibberd, M.L., Millward, B.A., Demaine, A.G. J. Diabetes Complicat. (1996) [Pubmed]
  11. Origin of reactive oxygen species in erythrocytes infected with Plasmodium falciparum. Atamna, H., Ginsburg, H. Mol. Biochem. Parasitol. (1993) [Pubmed]
  12. A review of techniques and results obtained in one laboratory by an integrated system of methods designed for routine clinical flow cytometric DNA analysis. Vindeløv, L.L., Christensen, I.J. Cytometry. (1990) [Pubmed]
  13. Physical mapping of the human T-cell receptor beta gene complex, using yeast artificial chromosomes. Hashim, Y., Ragoussis, I., Kearney, L., Tosi, S., So, A.K. Immunogenetics (1995) [Pubmed]
  14. Characterization of horse (Equus caballus) T-cell receptor beta chain genes. Schrenzel, M.D., Watson, J.L., Ferrick, D.A. Immunogenetics (1994) [Pubmed]
  15. Low platelet monoamine oxidase activity in Swedish imprisoned criminal offenders. Garpenstrand, H., Longato-Stadler, E., af Klinteberg, B., Grigorenko, E., Damberg, M., Oreland, L., Hallman, J. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. (2002) [Pubmed]
 
WikiGenes - Universities