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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Injury Severity Score

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Disease relevance of Injury Severity Score


Psychiatry related information on Injury Severity Score


High impact information on Injury Severity Score

  • METHODS: Consecutive adult patients admitted to a trauma center who had Injury Severity Scores of at least 9 and no intracranial bleeding were randomly assigned to heparin (5000 units) or enoxaprin (30 mg), each given subcutaneously every 12 hours in a double-blind manner, beginning within 36 hours after the injury [7].
  • Additionally, a shorter LOS was observed in patients with PAI and New Injury Severity Scores of 16 or higher (difference in adjusted mean LOS, 1.6 days [95% CI, -1.5 to 4.7 days]) and in all patients with multisystem blunt trauma admitted to higher-volume centers (difference in adjusted mean LOS, 3.3 days [95% CI, 0.91-5.70 days]) [8].
  • Analysis of admission data demonstrated no significant differences between the three groups with respect to extent of injury (injury severity score, ACOS trauma score) or physiologic assessments of organ function (serum creatinine, bilirubin, lactic acid) [9].
  • (The rate of net protein catabolism during TPN was 1.3 +/- 0.5 g/kg/day.) There was no correlation between the injury severity score (ISS) and the degree of metabolic abnormality [10].
  • Urine cortisol increased as a function of the interaction of age and Injury Severity Score (ISS) (r2 = 0.40, P < 0.001) [11].

Chemical compound and disease context of Injury Severity Score


Biological context of Injury Severity Score


Anatomical context of Injury Severity Score


Associations of Injury Severity Score with chemical compounds


Gene context of Injury Severity Score


Analytical, diagnostic and therapeutic context of Injury Severity Score

  • Patients less than 40 yr had lower mortality rates despite a significantly higher Injury Severity Score and lower Glasgow Coma Scale score compared with those greater than 65 yr [35].
  • METHODS: This retrospective study, based on formal autopsy findings from 111 earthquake-related deaths, evaluated demographic data, circumstances of death, rescue time, mechanisms of injury, causes of death, Abbreviated Injury Scale (AIS 90) and Injury Severity Score (ISS) values, vital functions, co-morbidity and preventable deaths [36].
  • METHODS: Charts of 106 patients with blunt hepatic injuries from July 1, 1991 to June 30, 1995 were reviewed for method of abdominal evaluation (computed tomography versus DPL), injury severity score, liver injury grade, method of management, length of stay (LOS), transfusion requirements, complications, and outcome [37].
  • Compared with National Trauma Data Bank information for patients with the same Injury Severity Scores, hospitalization was reduced by more than 55% for the entire series [38].
  • We determined concentrations of IL-10 in culture supernatants of 30 individual PMN fractions isolated from 18 severely traumatized patients (15 polytraumata, Injury Severity Score: 18-41, 3 severely burned patients) admitted to intensive care units [39].


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  13. The rapid infusion system: a superior method for the resuscitation of hypovolemic trauma patients. Dunham, C.M., Belzberg, H., Lyles, R., Weireter, L., Skurdal, D., Sullivan, G., Esposito, T., Namini, M. Resuscitation. (1991) [Pubmed]
  14. The determination of ketone bodies: preanalytical, analytical and physiological considerations. Laun, R.A., Rapsch, B., Abel, W., Schröder, O., Röher, H.D., Ekkernkamp, A., Schulte, K.M. Clin. Exp. Med. (2001) [Pubmed]
  15. Comparison of respiratory rate and peripheral oxygen saturation to assess severity in trauma patients. Raux, M., Thicoïpé, M., Wiel, E., Rancurel, E., Savary, D., David, J.S., Berthier, F., Ricard-Hibon, A., Birgel, F., Riou, B. Intensive care medicine. (2006) [Pubmed]
  16. Reintubation as an outcome predictor in trauma patients. Daley, B.J., Garcia-Perez, F., Ross, S.E. Chest (1996) [Pubmed]
  17. Multiplicity of solid organ injury: influence on management and outcomes after blunt abdominal trauma. Malhotra, A.K., Latifi, R., Fabian, T.C., Ivatury, R.R., Dhage, S., Bee, T.K., Miller, P.R., Croce, M.A., Yelon, J.A. The Journal of trauma. (2003) [Pubmed]
  18. Hypothermic coagulopathy in trauma: effect of varying levels of hypothermia on enzyme speed, platelet function, and fibrinolytic activity. Watts, D.D., Trask, A., Soeken, K., Perdue, P., Dols, S., Kaufmann, C. The Journal of trauma. (1998) [Pubmed]
  19. Substrate efficacy in early nutrition support of critically ill multiple trauma victims. Jeevanandam, M., Shamos, R.F., Petersen, S.R. JPEN. Journal of parenteral and enteral nutrition. (1992) [Pubmed]
  20. Cerebrospinal fluid and plasma nitrite and nitrate concentrations after head injury in humans. Clark, R.S., Kochanek, P.M., Obrist, W.D., Wong, H.R., Billiar, T.R., Wisniewski, S.R., Marion, D.W. Crit. Care Med. (1996) [Pubmed]
  21. Changes in monocytic expression of aminopeptidase N/CD13 after major trauma. Huschak, G., Zur Nieden, K., Stuttmann, R., Riemann, D. Clin. Exp. Immunol. (2003) [Pubmed]
  22. Profile of mothers at risk: an analysis of injury and pregnancy loss in 1,195 trauma patients. Ikossi, D.G., Lazar, A.A., Morabito, D., Fildes, J., Knudson, M.M. J. Am. Coll. Surg. (2005) [Pubmed]
  23. Results with abdominal vascular trauma in the modern era. Davis, T.P., Feliciano, D.V., Rozycki, G.S., Bush, J.B., Ingram, W.L., Salomone, J.P., Ansley, J.D. The American surgeon. (2001) [Pubmed]
  24. Severity of cervical spine ligamentous injury correlates with mechanism of injury, not with severity of blunt head trauma. Albrecht, R.M., Malik, S., Kingsley, D.D., Hart, B. The American surgeon. (2003) [Pubmed]
  25. Intensive insulin treatment in critically ill trauma patients normalizes glucose by reducing endogenous glucose production. Thorell, A., Rooyackers, O., Myrenfors, P., Soop, M., Nygren, J., Ljungqvist, O.H. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
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  27. Increased serum concentrations of procollagen type III peptide in severely injured patients: an indicator of fibrosing activity? Waydhas, C., Nast-Kolb, D., Trupka, A., Lenk, S., Duswald, K.H., Schweiberer, L., Jochum, M. Crit. Care Med. (1993) [Pubmed]
  28. Increased intestinal permeability following blunt and penetrating trauma. Langkamp-Henken, B., Donovan, T.B., Pate, L.M., Maull, C.D., Kudsk, K.A. Crit. Care Med. (1995) [Pubmed]
  29. The catecholamine response to multisystem trauma. Woolf, P.D., McDonald, J.V., Feliciano, D.V., Kelly, M.M., Nichols, D., Cox, C. Archives of surgery (Chicago, Ill. : 1960) (1992) [Pubmed]
  30. Increased incidence of sepsis and altered monocyte functions in severely injured type A- glucose-6-phosphate dehydrogenase-deficient African American trauma patients. Spolarics, Z., Siddiqi, M., Siegel, J.H., Garcia, Z.C., Stein, D.S., Ong, H., Livingston, D.H., Denny, T., Deitch, E.A. Crit. Care Med. (2001) [Pubmed]
  31. Elevated IL-8 production by trauma patients' monocytes is associated with elevated secretion of TNF alpha. De, A.K., Kodys, K., Puyana, J.C., Fudem, G., Savoie, P., Miller-Graziano, C.L. Shock (1995) [Pubmed]
  32. The immune microenvironment of human fracture/soft-tissue hematomas and its relationship to systemic immunity. Hauser, C.J., Zhou, X., Joshi, P., Cuchens, M.A., Kregor, P., Devidas, M., Kennedy, R.J., Poole, G.V., Hughes, J.L. The Journal of trauma. (1997) [Pubmed]
  33. The ratio of interleukin-6 to interleukin-10 correlates with severity in patients with chest and abdominal trauma. Taniguchi, T., Koido, Y., Aiboshi, J., Yamashita, T., Suzaki, S., Kurokawa, A. The American journal of emergency medicine. (1999) [Pubmed]
  34. Serum CRP and IL-6 levels after trauma. Not predictive of septic complications in 31 patients. Giannoudis, P.V., Smith, M.R., Evans, R.T., Bellamy, M.C., Guillou, P.J. Acta orthopaedica Scandinavica. (1998) [Pubmed]
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  36. Autopsy findings from 111 deaths in the 1999 Athens earthquake as a basis for auditing the emergency response. Papadopoulos, I.N., Kanakaris, N., Triantafillidis, A., Stefanakos, J., Kainourgios, A., Leukidis, C. The British journal of surgery. (2004) [Pubmed]
  37. Trends in the management of hepatic injury. Brasel, K.J., DeLisle, C.M., Olson, C.J., Borgstrom, D.C. Am. J. Surg. (1997) [Pubmed]
  38. The contribution of laparoscopy in evaluation of penetrating abdominal wounds. Ahmed, N., Whelan, J., Brownlee, J., Chari, V., Chung, R. J. Am. Coll. Surg. (2005) [Pubmed]
  39. Major injury induces increased production of interleukin-10 in human granulocyte fractions. Köller, M., Clasbrummel, B., Kollig, E., Hahn, M.P., Muhr, G. Langenbeck's archives of surgery / Deutsche Gesellschaft für Chirurgie. (1998) [Pubmed]
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