Disease relevance of Gastrointestinal Hemorrhage

• A patient with severe liver disease and mildly obnormal but stable renal function was given cimetidine on two occasions for gastrointestinal hemorrhage [1].
• To assess the efficacy of selective intestinal decontamination with norfloxacin in the prevention of bacterial infections in cirrhotic patients with gastrointestinal hemorrhage, 119 patients were included in a prospective randomized study [2].
• Cimetidine therapy has not been found to be useful in controlling acute upper gastrointestinal hemorrhage, acute pancreatitis, or several other conditions for which H2 blockade has been advocated [3].
• Sucralfate suspension versus titrated antacid for the prevention of acute stress-related gastrointestinal hemorrhage in critically ill patients [4].
• It is concluded that the continuous administration of propranolol may reduce incidences of recurrent upper gastrointestinal hemorrhage from gastric sources in patients with cirrhosis undergoing chronic sclerotherapy [5].

High impact information on Gastrointestinal Hemorrhage

• Histamine H2 antagonists in acute upper gastrointestinal hemorrhage [6].
• Technetium scans in the detection of gastrointestinal hemorrhage. Preoperative diagnosis of enteric duplication in an infant [7].
• The prevalence of gastroesophageal varices and gastrointestinal hemorrhage was determined in 124 patients with severe chronic active liver disease (CALD) receiving prednisone and followed regularly for up to 10 yr [8].
• Intraarterial vasopressin has been reported to be effective in the treatment of massive upper gastrointestinal hemorrhage [9].
• PURPOSE: To determine the efficacy of somatostatin or octreotide for the treatment of acute nonvariceal upper gastrointestinal hemorrhage [10].

Chemical compound and disease context of Gastrointestinal Hemorrhage

• Addition of nitroglycerin (NTG) improves the hemodynamic response to vasopressin and may thus be useful in the treatment of gastrointestinal hemorrhage [11].
• Combined warfarin and aspirin therapy was associated with greater fecal hemoglobin excretion than standard warfarin therapy, suggesting the potential for increased gastrointestinal hemorrhage [12].
• Aspirin is significantly associated with major upper gastrointestinal hemorrhage, whereas acetaminophen is not [13].
• Intestinal pseudopolyps and gastrointestinal hemorrhage due to cholesterol crystal embolization [14].
• None of the 12 cases of gastrointestinal hemorrhage reported in cefepime patients or five cases reported in ceftazidime patients were judged to be related to treatment drug [15].

Biological context of Gastrointestinal Hemorrhage

• Since the procedure was accomplished with ease and prolonged hemostasis obtained, we recommend it for gastrointestinal hemorrhage, especially in patients who are poor surgical risks or are unresponsive to vasopressin infusion, or both [16].
• As vasopressin began to be used widely to control gastrointestinal hemorrhage, there was concern over the effect of vasopressin on the hepatic circulation [17].

Anatomical context of Gastrointestinal Hemorrhage

• Accurate localization and surgical management of active lower gastrointestinal hemorrhage with technetium-labeled erythrocyte scintigraphy [18].
• During reduction of the dosage of steroid, massive gastrointestinal hemorrhage occurred from the upper jejunum, revealed by arteriography [19].
• A 31-year-old man had recurrent gastrointestinal hemorrhage after aortic valve replacement and initiation of anticoagulation therapy with coumadin [20].
• One of 2 patients with persistent fetal circulation (PFC) was treated with massive doses of tolazoline and suffered fatal gastrointestinal hemorrhage and ischemic necrosis of heart, spleen, testes, and adrenals [21].
• We have reported life-threatening gastrointestinal hemorrhage with hypoprothrombinemia in a patient treated with cefoperazone for a urinary tract infection [22].

Gene context of Gastrointestinal Hemorrhage

• Somatostatin for upper gastrointestinal hemorrhage and pancreatic surgery. A review of its pharmacology and safety [23].
• Risk of upper gastrointestinal hemorrhage in warfarin users treated with nonselective NSAIDs or COX-2 inhibitors [24].
• Gastrointestinal hemorrhage in Turner syndrome. Long-term follow-up with postmortem examination [25].
• We have developed a gastrointestinal hemorrhage model in mice and thereby assessed the potential risk of bleeding following administration of SM-20302, a nonpeptide GPIIb/IIIa receptor antagonist [26].
• The third patient was treated symptomatically and died from gastrointestinal hemorrhage and hepatic coma two years after the diagnosis of Budd-Chiari syndrome [27].

Analytical, diagnostic and therapeutic context of Gastrointestinal Hemorrhage

• Somatostatin or octreotide compared with H2 antagonists and placebo in the management of acute nonvariceal upper gastrointestinal hemorrhage: a meta-analysis [10].
• OBJECTIVE: To determine the efficacy and safety of cimetidine and sucralfate prophylaxis for stress-related gastrointestinal hemorrhage in patients admitted to a medical intensive care unit [28].
• The incidence of gastrointestinal hemorrhages among the 35 Swedish patients with active H. pylori infection, confirmed by a urea breath test, was 6.0 per 100 patient-years before eradication therapy versus 1.7 during the prospective followup [29].
• The authors conclude that prophylactic therapy (cimetidine or antacids) given without titration is associated with a lower frequency of upper gastrointestinal hemorrhage than when no medication is given [30].
• CONCLUSIONS: The use of glycolide copolymer staple-line reinforcement sleeves in patients undergoing laparoscopic gastric bypass is safe and significantly reduces staple-line bleeding sites and may reduce the incidence of gastrointestinal hemorrhage [31].

References