The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Lta4h  -  leukotriene A4 hydrolase

Rattus norvegicus

Synonyms: LTA-4 hydrolase, Leukotriene A(4) hydrolase, Leukotriene A-4 hydrolase
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Lta4h


Biological context of Lta4h


Anatomical context of Lta4h


Associations of Lta4h with chemical compounds


Analytical, diagnostic and therapeutic context of Lta4h


  1. Aminopeptidase B from the rat testis is a bifunctional enzyme structurally related to leukotriene-A4 hydrolase. Cadel, S., Foulon, T., Viron, A., Balogh, A., Midol-Monnet, S., Noël, N., Cohen, P. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  2. Prostaglandin E2 limits arachidonic acid availability and inhibits leukotriene B4 synthesis in rat alveolar macrophages by a nonphospholipase A2 mechanism. Christman, B.W., Christman, J.W., Dworski, R., Blair, I.A., Prakash, C. J. Immunol. (1993) [Pubmed]
  3. Isolation and characterization of a cDNA encoding rat liver cytosolic epoxide hydrolase and its functional expression in Escherichia coli. Knehr, M., Thomas, H., Arand, M., Gebel, T., Zeller, H.D., Oesch, F. J. Biol. Chem. (1993) [Pubmed]
  4. Gene expression of 5-, 12-, and 15-lipoxygenases and leukotriene receptors along the rat nephron. Reinhold, S.W., Vitzthum, H., Filbeck, T., Wolf, K., Lattas, C., Riegger, G.A., Kurtz, A., Krämer, B.K. Am. J. Physiol. Renal Physiol. (2006) [Pubmed]
  5. Ubiquitous localization of leukotriene A4 hydrolase in the rat nephron. Nakao, A., Watanabe, T., Ohishi, N., Toda, A., Asano, K., Taniguchi, S., Nosaka, K., Noiri, E., Suzuki, T., Sakai, T., Kurokawa, K., Shimizu, T., Kimura, S. Kidney Int. (1999) [Pubmed]
  6. Molecular cloning and functional expression of rat leukotriene A4 hydrolase using the polymerase chain reaction. Makita, N., Funk, C.D., Imai, E., Hoover, R.L., Badr, K.F. FEBS Lett. (1992) [Pubmed]
  7. Purification and characterisation of leukotriene A4 hydrolase from rat neutrophils. Evans, J.F., Dupuis, P., Ford-Hutchinson, A.W. Biochim. Biophys. Acta (1985) [Pubmed]
  8. Omega-[(omega-arylalkyl)aryl]alkanoic acids: a new class of specific LTA4 hydrolase inhibitors. Labaudinière, R., Hilboll, G., Leon-Lomeli, A., Lautenschläger, H.H., Parnham, M., Kuhl, P., Dereu, N. J. Med. Chem. (1992) [Pubmed]
  9. Modulation of pulmonary leukotriene formation and perfusion pressure by bestatin, an inhibitor of leukotriene A4 hydrolase. Muskardin, D.T., Voelkel, N.F., Fitzpatrick, F.A. Biochem. Pharmacol. (1994) [Pubmed]
  10. Specific induction of LTC4 synthase by retinoic acid in rat basophilic leukemia-1 cells. Hamasaki, Y., Abe, M., Matsumoto, S., Ichimaru, T., Hara, N., Miyazaki, S. Int. Arch. Allergy Immunol. (1994) [Pubmed]
  11. Changes of 5-lipoxygenase pathway and proinflammatory mediators in cerebral cortex and lung tissue of sensitized rats. Deng, Y.M., Xie, Q.M., Zhang, S.J., Chen, J.Q., Yang, Q.H., Bian, R.L. Acta Pharmacol. Sin. (2005) [Pubmed]
WikiGenes - Universities